The Role of Mesothelin Expression in Serous Ovarian Carcinoma: Impacts on Diagnosis, Prognosis, and Therapeutic Targets

Mesothelin (MSLN) is a protein expressed in the mesothelial cell lining of the pleura,peritoneum, and pericardium; its biological functions in normal cells are still unknown. Experimental studies using knockout mice have suggested that this molecule does not play an important role in development and reproduction. In contrast, it has been observed that this molecule is produced in abnormal amounts in several malignant neoplasms, such as mesotheliomas and pancreatic adenocarcinomas. Many molecular studies have also demonstrated that mesothelin is overexpressed in HSOCs. Here, we discuss the current knowledge of mesothelin and focus on its role in clinical and pathological diagnoses, as well as its impact on the prognosis of HSOC. Moreover, regarding the binding of MSLN to the ovarian cancer antigen CA125, which has been demonstrated in many studies, we also report on signal transduction pathways that may play an important role in the spread and neoplasticprogression of this lethal neoplasm. Given that mesothelin is overexpressed in many solid tumours and has antigenic properties, this molecule could be considered an antigenic target for the treatment of many malignancies. Consequently, we also review the literature to report on mesothelin-targeting therapies for HSOC that have been recently investigated in many clinical studies

L’intelligenza artificiale nei servizi sociali e sanitari: una nuova sfida al ruolo delle istituzioni pubbliche nel welfare italiano?

The paper illustrates the applications of digital and artificial intelligence technologies in social and health services and emphasizes the need of careful regulation by public authorities to ensure equality and constitutional rights

Brevi note sulla declinazione della sussidiarietà verticale nelle esperienze federo-regionali europee con uno sguardo alla pandemia

The study illustrates the development of the idea of subsidiarity and its recognition as a legal and constitutional principle in the sources of European states. Then analyzes the impact of the COVID-19 pandemic on the application of the principle in relations between levels of government in Germany, Swiss and Italy. In this crisis, the principle of subsidiarity can play an important role in enhancing the demands of the lowest levels of government, if accompanied by a robust and consolidated cooperative system between the center-periphery, while where the paths of collaboration and cooperation between the levels of government are weakening the principle of subsidiarity lends itself to a reading more favorable to centripetal dynamics

Prácticas educativas que facilitan el aprendizaje a niños con discapacidad múltiple y sordoceguera

Ningun

Coexistence of homologous-type carcinosarcoma of the cervix with undifferentiated carcinoma of the endometrium: A case report with Immunohistochemical analysis and literature review.

We report a case of undifferentiated carcinoma of the endometrium associated with malignant mixed Müllerian tumour of the uterine cervix. Immunohistochemical analysis with multiple markers was performed to demonstrate the coexistence of highly two aggressive components in the same uterus. Clinical data were collected and followed up, and a careful literature review was performed to establish the occurence of these components in a uterine malignancy

Prácticas educativas que facilitan el aprendizaje a niños con discapacidad múltiple

La trayectoria del equipo de investigación permite dar cuenta de la existencia de prácticas formales e informales que facilitan la adquisición de aprendizajes y la inclusión social de niños con discapacidad múltiple de 6 a12 años en diferentes entornos de América Latina y el Caribe de habla hispana. Por lo expuesto, se propone trabajar en su caracterización y socializar a partir de esta ponencia el estado de avance de la investigación.Orientado por el objetivo general de conocer en diferentes entornos de América Latina y Caribe estas prácticas, se ha diseñado una propuesta de trabajo que se nutre de elementos del enfoque cualitativo y cuantitativo Desde lo cuantitativo las estrategias metodológicas para recoger y analizar datos será a través de la implementación de un protocolo de observación. Desde los aspectos cualitativos se pretende avanzar en la descripción e interpretación de prácticas educativas que tienen lugar en algunos grupos, atendiendo a los significados propios de las culturas a las que pertenecen y poder comprenderlos así desde el punto de vista de los implicados en él.Trabajar con estos elementos busca contribuir al reconocimiento de las prácticas educativas que favorecen los aprendizajes, y enriquecer el conocimiento científico sobre el tema de estudio a partir de la realidad existente.Asimismo, adhiriendo a un modelo inclusivo, se considera que las acciones a desarrollar impactarán no sólo en los programas educativos sino en los diversos entornos donde se circunscriben recuperando el potencial educativo del medio familiar y social

Prácticas educativas facilitadoras de aprendizajes de niños con discapacidad múltiple y sordoceguera

Este trabajo focaliza el proyecto de investigación Prácticas Educativas que facilitan el Aprendizaje a Niños con Discapacidad Múltiple y/o con Sordoceguera aprobado en el 2016 por la Secretaría de Investigación de la Universidad Católica de Córdoba, Argentina, y su continuidad para el período 2019-2021. El objetivo es identificar en diferentes entornos de América Latina y el Caribe las características de las prácticas que favorecen la adquisición de aprendizajes significativos en niños con discapacidad de 6 a 12 años, minimizando los riesgos de exclusión. Para alcanzar el objetivo, la propuesta se nutre de elementos del enfoque cualitativo, a partir de: a. Entrevistas a informantes claves, presentes en los videos de la primera etapa de la investigación, para clarificar los aspectos no observables, implícitos y sus fundamentos; b. Grupos focales con la participación de especialistas en la temática para revelar las características que deben reunir las prácticas que facilitan aprendizajes. Analizar las prácticas educativas nos pone en contacto con las concepciones sobre educación y situación de discapacidad, permitiendo definir estrategias, decisiones y prioridades del currículo. Las políticas que caracterizan el contexto donde se desarrollan las prácticas también son un protagonista determinante que habilita o no el desarrollo de éstas. En una primera etapa se conocieron las prácticas educativas formales y no formales, con la tarea de describirlas, analizar los entornos que favorecen la inclusión para sistematizar la información, valorando y evaluando dichas prácticas a partir de los instrumentos utilizados. Actualmente realizaremos cuatro entrevistas a los profesionales involucrados en las prácticas de los vídeos analizados, utilizando ejes temáticos con la idea de garantizar la cobertura de todos los temas. Asimismo se realizará un grupo focal con profesionales y familias de personas con discapacidad buscando poner en tensión y enriquecer las características de las prácticas educativas que facilitan el aprendizaje

Exploring countermovement jump variables across competitive levels and playing positions in futsal

IntroductionThe aims of this study were to compare several countermovement jump (CMJ) kinetic variables between professional (PRO) and semi-professional (SEMI-PRO) futsal players and examine the differences amongst playing positions.MethodsCMJ performance from 56 male futsal players (25.2 ± 4.8 years; weight: 74.4 ± 6.4 kg) was analysed. Players were separated into PRO (n = 29; 27.0 ± 4.4 years; 75.4 ± 6.0 kg) and SEMI-PRO (n = 27; 22.7 ± 4.3 years; 73.1 ± 6.8 kg), and according to playing position: defenders (n = 16; 25.4 ± 3.7 years; 75.2 ± 6.0 kg), wingers (n = 26; 23.5 ± 4.5 years; 72.0 ± 6.9 kg), and pivots (n = 14; 28.0 ± 5.6 years; 77.8 ± 4.3 kg). Linear mixed models and effect sizes were used for the analyses based on the mean of two jumps for each variable.ResultsPRO players presented a deeper center of mass (COM) displacement (p = 0.002, ES = 0.83), greater eccentric (Ecc) absolute (p = 0.019, ES = 0.61) and relative peak power (p = 0.046, ES = 0.52), and achieved greater Ecc peak velocities (p = 0.004, ES = 0.76) when compared to SEMI-PRO. Non-significant and trivial-to-small differences were observed in all the other CMJ variables according to the competitive level and playing position.DiscussionEcc capabilities (i.e., deeper COM displacement, greater Ecc absolute and relative peak power, and peak velocity) during vertical jump seem to differentiate PRO and SEMI-PRO players. However, CMJ variables do not discriminate amongst playing positions in futsal players

La libertà di dissenso in Dante: attualità di una riflessione tardomedievale

Questo contributo esplora gli elementi in grado di testimoniare l’apprez zamento di Dante Alighieri verso la libertà di dissenso: alcuni specifici passaggi del le sue opere (indizi diretti); la struttura dei gironi infernali e il significato implicito di alcuni dei relativi contenuti (indizi indiretti); determinati episodi, benché fram mentari e variamente dibattuti dalla dottrina, della sua vita politica (indizi com portamentali). Lo scopo dell’indagine è duplice: da un lato, quello di evidenziare l’attualità della riflessione dantesca sul dissenso inteso come diritto/dovere di veico lare informazioni veritiere su quanto avviene nel contesto sociale di appartenenza; dall’altro, quello di rilevare l’impossibilità di ricondurre la tassonomia dantesca ai canoni del costituzionalismo contemporaneo, dove la libertà del dissenso è tutelata a prescindere dalla veridicità dei contenuti espressi dal dissenzienteThe right to dissent in Dante: the present relevance of a late medieval reflection. This essay explores the elements which can testify Dante Alighieri’s appreciation towards freedom of dissent: some specific passages of his works (direct clues); the structure of the infernal circles and the implicit meaning of some of their contents (indirect clues); some episodes of his political life, although fragmentary and de bated by doctrine, (behavioral clues). The purpose of the investigation is twofold: on the one hand, to highlight the relevance of Dante’s reflection on dissent under stood as the right/duty to convey truthful information on what happens in the so cial context of belonging; on the other, to argue the difficulty of matching Dante’s taxonomy with the canons of contemporary constitutionalism, where freedom of dissent is protected regardless of the truthfulness of the contents expressed by the dissente