Frequency of seropositivity to Toxocara canis in children of different socioeconomic strata

Para estudar a freqüência da infecção pelo Toxocara canis em crianças de classes sociais diferentes de Brasília, Brasil, foram testados soros de 602 crianças de ambos os sexos, de 1 a 12 anos, distribuídas em dois grupos representativos de condições socioeconômicas distintas. As amostras do primeiro grupo foram obtidas em laboratório público que atende bairros pobres. As do segundo grupo foram colhidas em laboratório privado, que serve à classe média. Os anticorpos anti-Toxocara foram detectados pelo método ELISA, com antígenos de Toxocara canis, e absorção com antígenos do Ascaris suum. A prevalência de soropositividade foi de 21,8% (66/302) no primeiro grupo e de 3% (9/300) no segundo (p<0,0001). Não houve diferença quanto ao gênero ou idade das crianças. Os resultados sugerem significativa prevalência de toxocaríase na população infantil de Brasília, com predomínio nas classes sociais menos favorecidas economicamente. __________________________________________________________________________________________ ABSTRACTFrequency of seropositivity for Toxocara in children from different socioeconomic strata in the city of Brasilia (Brazil) was measured. Six hundred and two children of both sexes, aged one to 12 years were distributed in two socioeconomically distinct groups. The samples of sera of the first group were obtained from blood drawn for routine tests in the laboratory of a public hospital attending children from low-income families. Samples from the second group were obtained from private laboratories attending children from middle-class families. Antitoxocara antibodies were detected by ELISA, using Toxocara canis excretory-secretory antigens previously absorbed with Ascaris suum extract. The prevalence of seropositivity was 21.8% (66/302) in the first group and 3% (9/300) in the second (p< 0.0001). No differences in frequency according to age or sex could be detected. Our results suggest a high prevalence of childhood toxocariasis in Brasilia, with children from lower income brackets being the most affected

Méthodologie de l' évaluation du risque thérapeutique chez la femme enceinte

PARIS-BIUP (751062107) / SudocSudocFranceF

Données récentes sur les conséquences d'une exposition intra-utérine au valproate de sodium

PARIS-BIUM (751062103) / SudocCentre Technique Livre Ens. Sup. (774682301) / SudocSudocFranceF

Le Centre de référence sur les agents tératogènes (CRAT) : une structure pionnière

Le Centre de référence sur les agents tératogènes (CRAT), fondé en 1975, premier organisme national et international consacré spécifiquement aux médicaments chez la femme enceinte, a innové en créant une structure d’information et de conseil destinée aux professionnels de santé, une méthodologie d’évaluation des risques, une méthodologie de recueil des données cliniques assortie d’une base de données de plus de 50 000 grossesses exposées à des agents exogènes, en créant le site www.lecrat.org accessible à tous, et en initiant le groupe de travail « reproduction, grossesse et allaitement » à l’Agence française de sécurité sanitaire des produits de santé (Afssaps)/ Agence nationale de sécurité du médicament et des produits de santé (ANSM), ainsi que le réseau européen European network teratology information services (ENTIS). Ces innovations constituent une avancée considérable, et contribuent à une meilleure prise en charge des femmes enceintes et de leurs nouveau-nés, ainsi qu’à la surveillance et la détection d’alertes. Le CRAT se tourne également vers les risques des médicaments sur la fertilité masculine et féminine, et l’impact des expositions paternelles sur la descendance

Bedaquiline and Linezolid for Extensively Drug-Resistant Tuberculosis in Pregnant Woman

A woman with extremely drug-resistant tuberculosis treated with a drug regimen including linezolid and bedaquiline during her last 3 weeks of pregnancy gave birth to a child without abnormalities. No fetal toxicities were noted by 2 years after delivery. This drug combination might be safe during the late third trimester of pregnancy

Bisphenol A at low doses: Updated evidence on reproductive function

International audienc

Pregnancy outcome after first trimester exposure to ionizing radiations

International audienceOBJECTIVE: To evaluate the effects of ionizing radiation exposure during the first trimester of pregnancy in usual clinical situations.STUDY DESIGN: We conducted a prospective observational cohort study using data collected between 1987 and 2014. This database was authorized by the French "Commission Nationale de l'Informatique et des Libertés". The exposed group consisted of 319 pregnant women exposed to sub diaphragmatic ionizing radiations for diagnostic purposes, during the first trimester of pregnancy, and the control group consisted of 319 pregnant women without any exposure or exposed to non-teratogenic agents. Data on maternal history and radiations exposure were collected on first contact, and pregnancy outcomes were documented at follow-up. An univariate analysis was performed to compare both groups for the main outcomes.RESULTS: Exposure to sub diaphragmatic ionizing radiation for diagnosis purpose (median fetal dose of 3.1 mGy [0.2-130.0]) during the first trimester of pregnancy was not significantly associated with an increased risk of malformations (1.5% vs 1.8%, p = 1.00), miscarriage (7.8% vs 7.2%, p = 0.88), in utero fetal death (0.3% vs 0%, p = 1.00) or fetal growth restriction (5.4% vs 3.5%, p = 0.62).CONCLUSION: Pregnant women exposed to irradiant diagnostic procedures do not present a higher risk of malformations, miscarriage, in utero fetal death or fetal growth restriction and should be reassured, even if the examination focused on the pelvis

Pregnancy outcome after first trimester exposure to ionizing radiations

International audienceOBJECTIVE: To evaluate the effects of ionizing radiation exposure during the first trimester of pregnancy in usual clinical situations.STUDY DESIGN: We conducted a prospective observational cohort study using data collected between 1987 and 2014. This database was authorized by the French "Commission Nationale de l'Informatique et des Libertés". The exposed group consisted of 319 pregnant women exposed to sub diaphragmatic ionizing radiations for diagnostic purposes, during the first trimester of pregnancy, and the control group consisted of 319 pregnant women without any exposure or exposed to non-teratogenic agents. Data on maternal history and radiations exposure were collected on first contact, and pregnancy outcomes were documented at follow-up. An univariate analysis was performed to compare both groups for the main outcomes.RESULTS: Exposure to sub diaphragmatic ionizing radiation for diagnosis purpose (median fetal dose of 3.1 mGy [0.2-130.0]) during the first trimester of pregnancy was not significantly associated with an increased risk of malformations (1.5% vs 1.8%, p = 1.00), miscarriage (7.8% vs 7.2%, p = 0.88), in utero fetal death (0.3% vs 0%, p = 1.00) or fetal growth restriction (5.4% vs 3.5%, p = 0.62).CONCLUSION: Pregnant women exposed to irradiant diagnostic procedures do not present a higher risk of malformations, miscarriage, in utero fetal death or fetal growth restriction and should be reassured, even if the examination focused on the pelvis