Regional Assessment of Soil Change in the Southwest Pacific

The Southwest Pacific region includes the 22 island nations of the Pacific1, New Zealand and Australia (Figure 15.1). The landscapes of the region are very diverse ranging from a large continental land mass through to tens of thousands of small islands across the enormous expanse of the southwest Pacific Ocean. There are extensive ancient flat lands through to some of the youngest and most tectonically active landscapes on the planet. Temperature and rainfall ranges are large because of the breadth of latitudes and elevations. As a consequence, the soils of the region are also diverse. The strongly weathered soils in humid tropical areas and the vast expanses of old soils across the Australian continent are particularly susceptible to disturbance and this is where some of the more intractable problems of soil management occur today

Pathogenic Germline Variants in 10,389 Adult Cancers

We conducted the largest investigation of predisposition variants in cancer to date, discovering 853 pathogenic or likely pathogenic variants in 8% of 10,389 cases from 33 cancer types. Twenty-one genes showed single or cross-cancer associations, including novel associations of SDHA in melanoma and PALB2 in stomach adenocarcinoma. The 659 predisposition variants and 18 additional large deletions in tumor suppressors, including ATM, BRCA1, and NF1, showed low gene expression and frequent (43%) loss of heterozygosity or biallelic two-hit events. We also discovered 33 such variants in oncogenes, including missenses in MET, RET, and PTPN11 associated with high gene expression. We nominated 47 additional predisposition variants from prioritized VUSs supported by multiple evidences involving case-control frequency, loss of heterozygosity, expression effect, and co-localization with mutations and modified residues. Our integrative approach links rare predisposition variants to functional consequences, informing future guidelines of variant classification and germline genetic testing in cancer. A pan-cancer analysis identifies hundreds of predisposing germline variants

Children are especially vulnerable to air pollution: We need data on transport emissions near schools

No abstract available