Increased complexin-1 and decreased miR-185 expression levels in Beh double dagger et's disease with and without neurological involvement

Although complexin 1 (CPLX1) is not known as an inflammation factor, recent identification of a complexin 1 (CPLX1) polymorphism in Beh double dagger et's disease (BD) has sparked an interest in the role of this molecule in autoinflammation. DNA samples were isolated from peripheral blood mononuclear cells (PBMC) of BD and neuro-Beh double dagger et's disease (NBD) patients and expression levels of CPLX1 and miR-185, a predicted target miRNA for CPLX1 and an inflammation-related miRNA, were investigated by real time PCR assays. PBMC expression levels of CPLX1 were significantly increased in BD and NBD patients. By contrast, levels of miR-185 were reduced in both patient groups. A moderate inverse correlation was found between levels of CPLX1 and miR-185. No correlation could be found between expression levels and clinical features of patients. Significant expression alterations of CPLX1 in BD and NBD patients suggest that this molecule has a proinflammatory action. The putative role of CPLX1 in BD pathogenesis remains to be further studied

Mitochondrial carrier homolog 1 (Mtch1) antibodies in neuro-Behcet's disease

WOS: 000326258200019PubMed ID: 24035008Efforts for the identification of diagnostic autoantibodies for neuro-Behcet's disease (NBD) have failed. Screening of NBD patients' sera with protein macroarray identified mitochondrial carrier homolog 1 (Mtch1), an apoptosis-related protein, as a potential autoantigen. ELISA studies showed serum Mtch1 antibodies in 68 of 144 BD patients with or without neurological involvement and in 4 of 168 controls corresponding to a sensitivity of 47.2% and specificity of 97.6%. Mtch1 antibody positive NBD patients had more attacks, increased disability and lower serum nucleosome levels. Mtch1 antibody might be involved in pathogenic mechanisms of NBD rather than being a coincidental byproduct of autoinflammation. (C) 2013 Elsevier B.V. All rights reserved

Novel Anti-Neuronal Antibodies in Neuromyelitis Optica Patients with or without Aquaporin-4 Antibodies

65th Annual Meeting of the American-Academy-of-Neurology (AAN) -- MAR 16-23, 2013 -- San Diego, CAWOS: 000332068601199…Amer Acad Neuro

Diseño de un sistema para la adquisición, generación y monitoreo de señales eléctricas del equipo CDTCS-5000 por medio de una interfaz humano máquina

Tesis (Ingeniero en Control y Automatización ), IPN, ESIME, Zacatenco, 2016, 1 archivo PDF, (159 páginas). tesis.ipn.m

Switch-associated protein 70 (SWAP 70) antibody levels are associated with clinical relapse in multiple sclerosis

11th International Congress of Neuroimmunology (ISNI) -- NOV 04-08, 2012 -- Boston, MAWOS: 000312764800046…European Sch Neuroimmunol, Int Soc Neuroimmunol (ISNI

Sorcin antibody as a possible predictive factor in conversion from radiologically isolated syndrome to multiple sclerosis: a preliminary study

To identify an antibody biomarker for prediction of conversion from radiologically isolated syndrome (RIS) to relapsing remitting multiple sclerosis (RRMS)