21 research outputs found
Measurement of serum interleukin 17 level in patients with genital warts before and after intralesional tuberculin injection
Introduction and aim: Genital wart infection is a
distressing sexually transmitted infection that causes marked fear and stress to
both males and females. Tuberculin Purified protein derivative (PPD) injection is
an upcoming safe and effective modality for the treatment of genital warts.
Interleukin 17 (IL-17) was found to be lower in wart patients than controls. This
study aimed at measurement of serum level of IL-17 in genital warts patients
before and after PPD injection.
Patients and methods: The study was carried out as case-control
interventional study on 63 patients (37 males and 26 females) with genital warts
attending Dermatology and Andrology Clinics, faculty of medicine, Suez Canal
University hospitals. 50 controls were enrolled in the study. All patients have
injected 10 tuberculin units of PPD intradermally in the mother or largest warts
every 2 weeks till 6 sessions. Serum level of IL-17 was measured by Sandwich
ELISA technique to all patients before and after PPD injection and to all control
subjects.
Results: The mean age of patients was 30.8 years, the mean duration of
warts was 4.73 months, the mean number of warts was 9.76 warts and 14.3% of
patients experienced side effects to PPD. (58.7%) of patients were completely
recovered from warts. Mean serum IL-17 was 81.1 ± 64.2 pg/mL versus 118.9
± 93.8 pg/mL in genital wart patients versus controls respectively
(P < 0.05) and 81.1 ± 64.2 pg/mL versus 107.1 ± 66.8 pg/mL
before and after PPD injection respectively (P < 0.05).
Conclusion: IL-17 serum level was significantly lower in genital wart
patients than normal controls. IL-17 serum level had been increased significantly
after PPD intralesional injection than pretreatment levels and significantly
related to clinical response to PPD. IL-17 suggested having a role in the
clinical efficacy of PPD in the treatment of genital warts
Access and utilisation of primary health care services comparing urban and rural areas of Riyadh Providence, Kingdom of Saudi Arabia
The Kingdom of Saudi Arabia (KSA) has seen an increase in chronic diseases. International evidence suggests that early intervention is the best approach to reduce the burden of chronic disease. However, the limited research available suggests that health care access remains unequal, with rural populations having the poorest access to and utilisation of primary health care centres and, consequently, the poorest health outcomes. This study aimed to examine the factors influencing the access to and utilisation of primary health care centres in urban and rural areas of Riyadh province of the KSA
Phytochemical And Biological Studies Of The Flowers And Fruits Of Pongamia Pinnata L.Pierre Growing In Egypt
The essential oil of the flowers of Pongamia pinnata L.Pierre was prepared by hydrodistillation and analysed using GS/MS technique. Thirty three components were identified, of which, β-citronellene (13.7%), limonene (13.35%) and trans caryophyllene (12.75%) were the major components. The retention indexes of the identified components were determined. GLC analysis of the fatty acid methyl esters prepared from the seed fixed oil and the petroleum ether extract of the flowers revealed the presence of oleic acid as the major fatty acid (84.8% and 34.86% respectively), while the major hydrocarbon detected in the unsaponifiable fraction was n-tetradecane (19.8%) and n-nonadecane (43.66%) respectively.Stigmasterol (3.12%) was the only sterol detected in the fixed oil of the seeds. The seed fixed oil and the aqueous and alcoholic extracts of the seed, flower and pericarp showed significant analgesic, antipyretic, anti-inflammatory, anti-ulcer and antidiabetic activities.Egyptian Journal of Biomedical Sciences Vol. 23 (1) 2007: pp. 1-1
Synthesis and biological effects of 2,3-diphenyl-5-methoxyindole and substituted benzophenone derivatives
Reactions of some cinnamoyl benzofuran derivatives with activated nitriles and their biological activity
Discriminative Metabolomics Analysis and Cytotoxic Evaluation of Flowers, Leaves, and Roots Extracts of <i>Matthiola longipetala</i> subsp. <i>livida</i>
Matthiola longipetala subsp. livida is an annual herb in Brassicaceae that has received little attention despite the family’s high reputation for health benefits, particularly cancer prevention. In this study, UPLC-HRMS-MS analysis was used for mapping the chemical constituents of different plant parts (i.e., flowers, leaves, and roots). Also, spectral similarity networks via the Global Natural Products Social Molecular Networking (GNPS) were employed to visualize their chemical differences and similarities. Additionally, the cytotoxic activity on HCT-116, HeLa, and HepG2 cell lines was evaluated. Throughout the current analysis, 154 compounds were annotated, with the prevalence of phenolic acids, glucosinolates, flavonol glucosides, lipids, peptides, and others. Predictably, secondary metabolites (phenolic acids, flavonoids, and glucosinolates) were predominant in flowers and leaves, while the roots were characterized by primary metabolites (peptides and fatty acids). Four diacetyl derivatives tentatively assigned as O-acetyl O-malonyl glucoside of quercetin (103), kaempferol (108 and 112), and isorhamnetin (114) were detected for the first time in nature. The flowers and leaves extracts showed significant inhibition of HeLa cell line propagation with LC50 values of 18.1 ± 0.42 and 29.6 ± 0.35 µg/mL, respectively, whereas the flowers extract inhibited HCT-116 with LC50 24.8 ± 0.45 µg/mL, compared to those of Doxorubicin (26.1 ± 0.27 and 37.6 ± 0.21 µg/mL), respectively. In conclusion, the flowers of M. longipetala are responsible for the abundance of bioactive compounds with cytotoxic properties