Climate Change, Migration, and Adaptation in the MENA Region

Climate change is a major source of concern in the Middle East and North Africa (MENA) region, and migration is often understood as one of several strategies used by households to respond to changes in climate and environmental conditions, including extreme weather events. Other coping and adaptation strategies include changing the household’s sources of livelihood, and selling assets or taking other emergency measures in cases of losses due to extreme weather events. Yet while there is a burgeoning literature on climate change and migration and other adaptation strategies worldwide, the evidence available for the MENA region remains limited, in part because of a lack of survey and other data. This chapter is based in large part on new data collected in 2011 in Algeria, Egypt, Morocco, Syria, and Yemen. Household surveys were implemented in two climate affected areas in each country. In addition, qualitative focus groups were also implemented in both urban and rural areas. Finally, complementary work was completed using existing data sources for Morocco and Yemen. The chapter provides a summary of some of the main findings from these various sources of data, focusing on household perceptions about climate change and extreme weather events, migration, other household coping and adaptation strategies, and government and community responses. Overall, households do perceive important change in the climate, and many have been affected by extreme weather events with resulting losses in income, crops, livestock, or fish catchment. The coping and adaptation strategies used by households to deal with shocks are diverse but limited, as are the community and government programs which could help households better cope with and adapt to climate change. In terms of migration, in the areas affected by climate change and weather shocks, the analysis suggests that climate factors may account for between one tenth and one fifth of the overall level of migration observed today, but this is likely to increase as climatic conditions continue to deteriorate. While migrants appreciate the opportunities that migration offer, their living conditions and ability to be well integrated in their areas of destination is far from being guaranteed

Anti-Inflammatory, Antipyretic, and Analgesic Properties of Potamogeton perfoliatus Extract: In Vitro and In Vivo Study

Natural antioxidants, especially those of plant origins, have shown a plethora of biological activities with substantial economic value, as they can be extracted from agro-wastes and/or under exploited plant species. The perennial hydrophyte, Potamogeton perfoliatus, has been used traditionally to treat several health disorders; however, little is known about its biological and its medicinal effects. Here, we used an integrated in vitro and in vivo framework to examine the potential effect of P. perfoliatus on oxidative stress, nociception, inflammatory models, and brewer’s yeast-induced pyrexia in mice. Our results suggested a consistent in vitro inhibition of three enzymes, namely 5-lipoxygenase, cyclooxygenases 1 and 2 (COX-1 and COX-2), as well as a potent antioxidant effect. These results were confirmed in vivo where the studied extract attenuated carrageenan-induced paw edema, carrageenan-induced leukocyte migration into the peritoneal cavity by 25, 44 and 64% at 200, 400 and 600 mg/kg, p.o., respectively. Moreover, the extract decreased acetic acid-induced vascular permeability by 45% at 600 mg/kg, p.o., and chemical hyperalgesia in mice by 86% by 400 mg/kg, p.o., in acetic acid-induced writhing assay. The extract (400 mg/kg) showed a longer response latency at the 3 h time point (2.5 fold of the control) similar to the nalbuphine, the standard opioid analgesic. Additionally, pronounced antipyretic effects were observed at 600 mg/kg, comparable to paracetamol. Using LC-MS/MS, we identified 15 secondary metabolites that most likely contributed to the obtained biological activities. Altogether, our findings indicate that P. perfoliatus has anti-inflammatory, antioxidant, analgesic and antipyretic effects, thus supporting its traditional use and promoting its valorization as a potential candidate in treating oxidative stress-associated diseases

Gastro-Protective Effects of Albizia anthelmintica Leaf Extract on Indomethacin-Induced Gastric Ulcer in Wistar Rats: In Silico and In Vivo Studies

We have previously reported that the leaf extract of Albizia anthelmintica exhibited substantial antioxidant, anti-inflammatory, analgesic, and antipyretic properties in vivo. We also comprehensively characterized the active phytoconstituents and found several flavonoids and galloyl glucosides derivatives. In the current work, we explored the gastroprotective effects of the leaf extract in an indomethacin-induced ulcer model and the mechanisms involved. The rats being pretreated with the tested extract (100 and 200 mg kg−1) significantly prevented gastric lesions by 87.4% and 92.3%, respectively, and they had no structural derangements in the gastric mucosa. The extract significantly reduced the elevated levels of IKκB, NF-κB, TNF-α, IL-6, iNOS, and lipid peroxidation; increased the reduced level of glutathione peroxidase (GPx) activity; and reduced glutathione (GSH) in the indomethacin-induced ulcer model. The protective activities of the extract were similar in most aspects to those exerted by the known anti-ulcer drug famotidine. These activities might be attributed to the anti-inflammatory and antioxidant activities, and the reduction of iNOS levels. In conclusion, Albizia anthelmintica is a potential candidate for management of gastric ulcers with antioxidant properties

Accommodation of climate change in coastal areas of cameroon: selection of household-level protection options

Climate change, Coastal residents, Protection options,