4,928 research outputs found
Histopathological and immunohistochemical study of the protective effect of triptorelin on the neurocytes of the hippocampus and the cerebral cortex of male albino rats after short-term exposure to cyclophosphamide
AbstractChemotherapy treats many types of cancer effectively but it often causes side effects. Chemotherapy works on active cells, such as cancer cells, and some healthy cells. Side effects happen when chemotherapy damages these healthy cells. Today, many more drugs are available to treat side effects than in the past. Triptorelin (Decapeptyl) is a gonadotropin-releasing hormone agonist that is reported to have many therapeutic effects besides being an anti-cancer agent. In the current study, intraperitoneal cyclophosphamide (65mg/kg/day) was administered for 4 weeks to induce marked dystrophic changes in the cerebral cortex and hippocampus of male albino rats. After 4 weeks, we observed significant degeneration of neurocytes with dystrophic changes. Subcutaneous triptorelin (0.05mg/kg/day) for 4 weeks significantly improved histological signs of degeneration and apoptosis. Anti-Bcl2 staining of sections of the cerebral cortex and hippocampus showed that the apoptotic index was increased. This finding was confirmed by the anti-p53 staining, which showed a significant decrease in the apoptotic index. Ultimately, such improvements were accompanied by significant restoration of normal brain histology, as revealed by hematoxylin and eosin. In conclusion, triptorelin can reverse the apoptotic changes induced by cyclophosphamide therapy, which is more marked in the hippocampus than cerebral cortex
A Novel Tunicate Swarm Algorithm with Hybrid Deep Learning Enabled Attack Detection for Secure IoT Environment
Sero-prevalence and risk factors associated with toxoplasma gondii infection among pregnant women in Alexandria, Egypt
Background: Toxoplasma gondii infection during pregnancy can result in fetal death, neonatal death or various congenital defects. This study aimed to estimate the seroprevalence of toxoplasma gondii infection using two different diagnostic tests, Enzyme-Linked Immunosorbent Assay (ELISA) versus Immunochromatographic assay (ICA) and to study the potential risk factors for acquiring infection in pregnant women attending antenatal care clinics in Alexandria, Egypt.Methods: A cross sectional study, conducted between May 2015 and June 2016. The study was done in antenatal care centers of most districts of Alexandria Governorate, Egypt. 382 pregnant women, of a gestational age between 8-40 weeks were included in the study and were given pretested structured questionnaire to assess risk factors, which included: demographic, socio-economic data, kitchen hygiene and behavioral variables. Blood samples were taken and sera were divided into two parts; the first part was examined for anti-T.gondii IgG and IgM antibodies using rapid diagnostic test RDT kit, the other part tested by ELISA.Results: The overall seroprevalence of T.gondii infection was (11.3%) detected by RDT, significantly increased to (57.9%) by ELISA test (X2= 5.3; p=0.001). RDT had the sensitivity of (15.8%), the specificity of (95%), PPV of (81.4%), NPV of (45.1%), with overall diagnostic efficiency of (49.2%). The association between T.gondii infection and the age of the pregnant women was found to be statistically significant (OR=2.84, 95%CI=1.251-6.455).Conclusions: The present study has documented a bad diagnostic performance of RDT in detection T.gondii in serum samples of infected pregnant women as compared to ELISA technique. Age is the only risk factor to be associated statistically with toxoplasma gondii infection
Transition to complete synchronization in phase coupled oscillators with nearest neighbours coupling
We investigate synchronization in a Kuramoto-like model with nearest
neighbour coupling. Upon analyzing the behaviour of individual oscillators at
the onset of complete synchronization, we show that the time interval between
bursts in the time dependence of the frequencies of the oscillators exhibits
universal scaling and blows up at the critical coupling strength. We also bring
out a key mechanism that leads to phase locking. Finally, we deduce forms for
the phases and frequencies at the onset of complete synchronization.Comment: 6 pages, 4 figures, to appear in CHAO
Ellipticity Statistics of Ultra Wideband MIMO Channels for Body Centric Wireless Communication
In this paper, ellipticity statistics of 2 × 2 ultra wideband multiple-input-multiple-output (MIMO) channel for body-centric wireless communication is evaluated by quantifying four different on body links namely; waist-back, waist-chest, waist-ankle and waist-wrist. Results show that at lower values of signal to noise (SNR), spatial multiplexing dependent capacity degrades as the eigen value dispersion decreases (i.e., lower ellipticity statistic), whereas it increases at higher values of SNR
Decay
Motivated by the experimental measurement of the decay rate, , and
the longitudinal polarization, , in the Cabibbo favored decay , we have studied theoretical prediction within the context of
factorization approximation invoking several form factors models. We were able
to obtain agreement with experiment for both and by using
experimentally measured values of the form factors ,
and in the semi-leptonic decay . We have also included in our calculation the effect of the
final state interaction () by working with the partial waves amplitudes
, and . Numerical calculation shows that the decay amplitude is
dominated by wave, and that the polarization is sensitive to the
interference between and waves. The range of the phase difference
accommodated by experimental error in
is large.Comment: 7 pages, LaTe
Molecular Systematic Study Of The Genus Fagonia L. In Libya
Molecular analyses of ten Fagonia species grown widely in the Libyan Desert have been carried to investigate the taxonomic relationship between them and to evaluate the genetic distances among them. To achieve our aim RAPD technique carried out through six arbitrary primers. Comparing with ladder DNA marker, the obtained data were computerized and analyzed using SYSTAT program. The studied species are F. arabica L., F. bruguieri DC, F. cretica L., F.glutinosa Delile, F. indica Burm., F. microphylla Pomel, F. sinaica Boiss, F. schweinfurthii Hadidi, F. tenuifolia Steud. and F.thebaica Boiss. The genetic variability among the ten Fagonia species estimated using the DNA protein sequencing obtained from primer 1, indicates that F. indica and F. glutinosa are very closely related while F.cretica, F.microphylla and F.arabica related to each other and gathered together in another group. The dendrograms of the six primers via UPGMA method according to RAPD finger printing gave two clusters with homology percentage 9%. The first one has F.microphylla and F.schweinfurthii at 50% similarity index. The second cluster divided into two sub-clusters. The first one included three Fagonia species (F.cretica; F.indica and F.glutinosa). The second sub-cluster subdivided into two other sub-clusters. The first one contained F.arabica and F.bruguieri at 50% similarity index. The other sub-cluster gathered F.sinaica and F.thebaica and, both species in genetic relationship with F.tenuifolia.Molecular analyses of ten Fagonia species grown widely in the Libyan Desert have been carried to investigate the taxonomic relationship between them and to evaluate the genetic distances among them. To achieve our aim RAPD technique carried out through six arbitrary primers. Comparing with ladder DNA marker, the obtained data were computerized and analyzed using SYSTAT program. The studied species are F. arabica L., F. bruguieri DC, F. cretica L., F.glutinosa Delile, F. indica Burm., F. microphylla Pomel, F. sinaica Boiss, F. schweinfurthii Hadidi, F. tenuifolia Steud. and F.thebaica Boiss. The genetic variability among the ten Fagonia species estimated using the DNA protein sequencing obtained from primer 1, indicates that F. indica and F. glutinosa are very closely related while F.cretica, F.microphylla and F.arabica related to each other and gathered together in another group. The dendrograms of the six primers via UPGMA method according to RAPD finger printing gave two clusters with homology percentage 9%. The first one has F.microphylla and F.schweinfurthii at 50% similarity index. The second cluster divided into two sub-clusters. The first one included three Fagonia species (F.cretica; F.indica and F.glutinosa). The second sub-cluster subdivided into two other sub-clusters. The first one contained F.arabica and F.bruguieri at 50% similarity index. The other sub-cluster gathered F.sinaica and F.thebaica and, both species in genetic relationship with F.tenuifolia
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