Disease Control of Pulmonary Inflammatory Pseudotumor by Multidisciplinary Approach

Introduction: Inflammatory pseudotumor is a rare tumor of the lung, which is usually misdiagnosed as malignancy. Most of early cases are treated with complete excision, but advanced cases: radiation therapy, steroids and chemotherapy will be a part of treatment plan. Multidisciplinary approach can save many cases of inflammatory pseudotumor and other rare diseases.Case Report: we reporting a case of advanced inflammatory pseudotumor with had a long disease control with multidisciplinary approach in the form of chemotherapy, steroids, radiation therapy and surgery.Conclusion: Advanced IP of the lung is rare disease with unknown etiology, where multidisciplinary team is needed for diagnosis and treatment: maximum safe debulking, chemotherapy, radiation therapy and steroids can be the suitable combined treatment for many advanced case

Mechanism of Nickel and Chromium-Induced Immunotoxicity and Oxidative Stress: A Comparative Study

Abstract Introduction: Chromium (Cr) and Nickel (Ni) are examples of commonly used industrial substances with negative long time exposure on human health. One mechanism whereby metals can alter health is through modulation of immune homeostasis. They are capable of producing oxidative stress and it is possible that this oxidative stress contributes to the carcinogenic response of these metals

Impact of opioid-free analgesia on pain severity and patient satisfaction after discharge from surgery: multispecialty, prospective cohort study in 25 countries

Background: Balancing opioid stewardship and the need for adequate analgesia following discharge after surgery is challenging. This study aimed to compare the outcomes for patients discharged with opioid versus opioid-free analgesia after common surgical procedures.Methods: This international, multicentre, prospective cohort study collected data from patients undergoing common acute and elective general surgical, urological, gynaecological, and orthopaedic procedures. The primary outcomes were patient-reported time in severe pain measured on a numerical analogue scale from 0 to 100% and patient-reported satisfaction with pain relief during the first week following discharge. Data were collected by in-hospital chart review and patient telephone interview 1 week after discharge.Results: The study recruited 4273 patients from 144 centres in 25 countries; 1311 patients (30.7%) were prescribed opioid analgesia at discharge. Patients reported being in severe pain for 10 (i.q.r. 1-30)% of the first week after discharge and rated satisfaction with analgesia as 90 (i.q.r. 80-100) of 100. After adjustment for confounders, opioid analgesia on discharge was independently associated with increased pain severity (risk ratio 1.52, 95% c.i. 1.31 to 1.76; P < 0.001) and re-presentation to healthcare providers owing to side-effects of medication (OR 2.38, 95% c.i. 1.36 to 4.17; P = 0.004), but not with satisfaction with analgesia (beta coefficient 0.92, 95% c.i. -1.52 to 3.36; P = 0.468) compared with opioid-free analgesia. Although opioid prescribing varied greatly between high-income and low- and middle-income countries, patient-reported outcomes did not.Conclusion: Opioid analgesia prescription on surgical discharge is associated with a higher risk of re-presentation owing to side-effects of medication and increased patient-reported pain, but not with changes in patient-reported satisfaction. Opioid-free discharge analgesia should be adopted routinely

Erratum to: Study of the structural, electrical and optical properties of Ge-Pb-Te nanocrystals

This erratum corrects a mistake happened in Figure 1 in the article. In the recent version Figure 1 is incorrect, we need to exchange it with the correct figure attached with this erratum

Study of the structural, electrical and optical properties of Ge-Pb-Te nanocrystals

Nanocrystals of Pb37.5Ge12.5Te50 with average size 24 nm are prepared using direct solid state reactions of pure elements in vacuum. The obtained Pb37.5Ge12.5Te50 nanocrystal alloy was used as a starting material for preparing thin films by inert gas condensation (IGC) technique. The obtained thin films show a nanocrystalline structure. Particle size of thin film increases from 4.3 to 6.9 nm with increasing film thickness from 10 to 60 nm. Optical studies for thin films revealed a direct allowed electronic transition. The values of optical band gap Eopg decreased from 2.26 to 1.63 eV with increasing film thickness from 10 to 60 nm and inversely proportional to particle size. The electrical conductivity of nanocrystalline thin films was enhanced by a factor of 1000 times with increasing film thickness from 10 to 60 nm. The reduction of electrical conductivity during cooling cycle for 46 and 60 nm film thicknesses can be explained by the so-called core-shell model. The growth of crystal during heating process causes an increase in thin film resistance during cooling which reduces the probability of the presence of current paths within thin film

Influence of Film Thickness and Heat Treatment on the Physical Properties of Mn Doped Sb2Se3 Nanocrystalline Thin Films

Nanocrystalline thin films of Sb37.07Mn1.95Se60.98 with different thickness (7, 20, 40, and 80 nm) were successfully prepared via inert gas condensation technique. As-deposited films showed amorphous structure by grazing incident in-plane X-ray diffraction (GIIXD) technique. All films of different thicknesses were heat treated at 433 K for 90 min. The GIIXD pattern of annealed films showed nanocrystalline orthorhombic structure. The effect of thickness of annealed films on the structure and optical properties was studied. Calculated particle sizes are 20.67 and 24.15 for 40 and 80 nm thickness of heat treated film. High resolution transmission electron microscope HRTEM images and their diffraction patterns proved that 40 nm film thickness annealed at different temperature has nanocrystalline nature with observed (high) crystallinity that increases with annealing temperature. Blue shift of optical energy gap was observed from 1.68 to 2 eV with decreasing film thickness from 80 to 7 nm. Film thickness of 40 nm was exposed to different heat treated temperatures from 353 to 473 K to detect its effect on structure and optical and electrical properties. Blue shift from 1.73 to 1.9 eV was observed in its optical band gap due to direct transition as heat treatment temperature decreasing from 473 to 353 K. Electrical conductivity was studied for different heat treated films of thickness 40 nm, and intrinsic conduction mechanism is dominant. The activation energy Ea was affected by heat treatment process

Simple molecular diagnostic method for Fragile X syndrome in Egyptian patients: Pilot study

Background: Poor knowledge about Fragile X syndrome (FXS) may be a major barrier to early diagnosis that could improve quality of life and prognosis especially in the developing countries. Aim: The aim of this study was to evaluate simple and reproducible method for premutation detection in females of fragile X families for the first time in Egypt. Subjects and Methods: We have developed a rapid modified polymerase chain reaction (PCR)-based screening tool for expanded Fragile X mental retardation 1 (FMR1) alleles. This method utilizes betaine as additive to facilitate FMR 1 gene amplification. We screened fifty three males, thirty two first-degree females; twenty normal healthy controls in addition to six reference samples. Results: Simple PCR method showed 16 males with abnormal CGG repeats, where 10 of their mothers and four sisters had FMR 1 premutation. Consanguineous marriage was present in 66.6% percent of the studied families. Studying the correlation between genotype and clinical manifestations showed premature ovarian failure in 40% and learning disability in 50% of the studied female carriers. Conclusion: FXS has to be ruled out in families with consanguineous parents, before assuming that familial mental retardation is due to autosomal recessive gene defects. Early carrier detection may reduce the number of affected children. In conclusion, more studies are still needed of much larger sample size with known allele sizes in order to guarantee the accuracy of the method used

A study of the structural, optical, and ferroelectric characteristics of Pb-Ge-Te nanocrystalline alloys as potential candidates for memory devices and Near-Infrared (NIR) applications

Pb50-xGexTe50 (x = 15, 20, 25, 30 at. %) nanocrystalline bulk alloys were prepared using solid-state direct reaction. X-ray diffraction and high-resolution transmission electron microscopy (HR-TEM) analysis of the reference structure (Ge = 15 at.%) revealed a slightly distorted cubic structure, with a lattice parameter of 6.43 Å and an inter-axis unit cell angle of 88.69°. Atomic force images\u27 analysis and histograms displayed a homogenous particle size distribution in the nanoscale for all samples. Density measurements showed a gradual decrease from 7.89 to 6.98 g/cm3 with increasing Ge content in agreement with the calculated values. The polarization–field hysteresis behavior verifies the ferroelectric activity of the prepared alloys, suggesting them as potential candidates for non-volatile ferroelectric memory devices (NVFRAMs) applications. Optical properties analyzed using diffuse reflectance measurements exhibited direct transitions with a bandgap decreasing from 1.57 to 1.35 eV with increasing Ge content matching the near-infrared spectrum (NIR) perfectly

Tuning Paramagnetic effect of Co-Doped CdS diluted magnetic semiconductor quantum dots

Diluted magnetic semiconductor quantum dots (DMS-QDs) are known for their outstanding optical and magnetic properties. II–VI DMS-QDs, in particular, are interesting for spintronics, nonvolatile memory, and magneto-optical devices. Therefore, studying the optical and magnetic properties of different II-VI semiconductors doped with transition metal atoms is of great importance. Tuning II-VI QDs optical properties can be mastered by changing the QDs particle size and/or structure. However tuning the magnetic properties of DMS-QDs is still within trial and error verification, although it is crucial in targeting different applications in spintronics. We hereby demonstrate, the ability to tune the paramagnetic effect of homogeneous Co-doped CdS QDs following a co-precipitation synthesis route with different Co2+ concentrations. The structural, optical and magnetic properties have been comprehensively studied. The dopant cobalt atoms concentration and chemical-configuration were precisely tracked by x-ray photoemission spectroscopy. Excitingly, the different Co-concentrations of 2, 5 and 10% significantly improve the magnetic properties of the CdS QDs, which exhibit a paramagnetic concentration-dependent effect. With 10% of Co atoms, we were able to achieve ~ 200 x 10(-6) molar susceptibility, that is, the same value to that of pure CoS. Thus we could obtain the highest possible paramagnetic effect in the CdS semiconducting matrix exhibiting 2.76 eV band gap, i.e. in the visible range. This efficacious result encourages the use of the present method in preparing DMS-QDs materials targeting various spintronics applications.AE and IM are acknowledging the funding provided by the joint Russian Egyptian STDF project no. 13756. AE is also grateful also for the general administration of Missions at the Ministry of High Education in Egypt for funding the mission trip to Centro de Fisica de Materiales on 2016. CR and EO are grateful for funding from the Spanish Ministry of Economy and Competitiveness (grant MAT2016-78293-C6-5-R, including FEDER funds), the Basque Government (grant IT-1255-19) and the Interreg POCTEFA V-A Spain–France–Andorra Program (EFA 194/16/TNSI) partly financed by ERDF funds.Peer reviewe