43 research outputs found
Oxidative stress and cytotoxic potential of anticholinesterase insecticide, malathion in reproductive toxicology of male adolescent mice after acute exposure
Objective(s):The present study was undertaken to determine the effects of acute exposure to malathion on oxidative stress and cytotoxic potential of anticholinesterase insecticide, malathion in reproductive toxicology of adolescent male mice.
Materials and Methods: Thirty two adolescent male mice at pubertal age were treated with 500 mg/kg body weight (BW) of malathion for three days. After exposure, biochemical markers and sperm analysis were evaluated and finally histological modifications of testis and sperm were assessed.
Results: Our data showed that treatment of male mice with malathion (500 mg/kg, BW) could lead to oxidative stress. Induced oxidative stress status can be assessed due to increased malondialdhyde (MDA) content, decreased thiol group content, as well as increased antioxidant enzyme activities. On the other hand, exposure to malathion at the pubertal age led to alteration of semen parameters; sperm production and percentage of motile sperm were decreased in the treated groups compared to the control. Furthermore, exposure of male mice to malathion led to a decrease of testosterone level, inhibition of acetylcholinesterase, and decrease of the reproductive performance of male mice after three days of treatment at the age of puberty.
Conclusion: The importance to carry out in vitro reproductive toxicology assays lies on the need of knowing the alterations these insecticides may cause at cellular level, since they are endocrine disruptors that interfere with reproductive functions
Blépharochalasis d'installation rapide.
peer reviewedLe blĂ©pharochalasis est une affection rare caractĂ©risĂ©e par des poussĂ©es oedĂ©mateuses des paupiĂšres aboutissant Ă une altĂ©ration de leur structure fine et principalement Ă un relĂąchement cutanĂ©. Il est le plus souvent bilatĂ©ral et atteint prĂ©fĂ©rentiellement les paupiĂšres supĂ©rieures. Nous rapportons lâobservation dâune jeune fille de 11 ans, qui prĂ©sente un blĂ©pharochalasis qui sâest installĂ© 3 mois aprĂšs des Ă©pisodes successifs pratiquement subintrants dâĆdĂšme palpĂ©bral. Le diagnostic a Ă©tĂ© Ă©toffĂ© par un examen histologique qui a montrĂ© une absence quasi totale de fibre Ă©lastique. Le blĂ©pharochalasis survient habituellement chez le sujet jeune. Deux formes cliniques sont classiquement dĂ©crites : la forme hypertrophique et la forme atrophique, observĂ©e chez notre patiente. Lâatrophie des paupiĂšres sâinstalle progressivement sur plusieurs annĂ©es suite Ă des poussĂ©es ĆdĂšmateuses qui durent quelques jours et qui surviennent 3 Ă 4 fois par an
Timeâmotion analysis and physiological data of elite underâ19âyearâold basketball players during competition
The physical demands of modern basketball were assessed by investigating 38 elite underâ19âyearâold basketball players during competition. Computerised timeâmotion analyses were performed on 18 players of various positions. Heart rate was recorded continuously for all subjects. Blood was sampled before the start of each match, at half time and at full time to determine lactate concentration. Players spent 8.8% (1%), 5.3% (0.8%) and 2.1% (0.3%) of live time in high âspecific movementsâ, sprinting and jumping, respectively. Centres spent significantly lower live time competing in highâintensity activities than guards (14.7% (1%) v 17.1% (1.2%); p<0.01) and forwards (16.6% (0.8%); p<0.05). The mean (SD) heart rate during total time was 171 (4)â
beats/min, with a significant difference (p<0.01) between guards and centres. Mean (SD) plasma lactate concentration was 5.49 (1.24)â
mmol/l, with concentrations at half time (6.05 (1.27)â
mmol/l) being significantly (p<0.001) higher than those at full time (4.94 (1.46)â
mmol/l). The changes to the rules of basketball have slightly increased the cardiac efforts involved during competition. The game intensity may differ according to the playing position, being greatest in guards