Haemorheologic and fibrinolytic activity in Nigerian HIV infected

Objective: Human immunodeficiency virus (HIV)-infected patients, especially those on antiretrovirals are at risk of cardiovascular disease (CVD). The haemorheologic and fibrinolgtic activity of treatment naïve Nigerian HIV-infected patients were investigated. Methods: Blood was collected from 50 newly diagnosed treatment naïve HIV-infected patients and 50 apparently healthy HIV seronegative individuals that served as controls. Haematocrit values, plasma and serum viscosity, plasma fibrinogen concentration and euglobin lysis time were determined. Result: The mean ± standard deviation of haematocrit value of HIV infected patients (31.70 ± 6.33%) was significantly lower (

Plasma Fibrinogen Estimation: a Comparison of the Heat Precipitation and Dry Weight Methods

Plasma fibrinogen occupies a central role in coagulation as well as being a predictor of inflammation and cardiovascular disease. Thus a simple and rapid method for its estimation will be advantageous. A total of 80 apparently healthy volunteers were used in this study and plasma fibrinogen was estimated by a heat precipitation and a dry weight method. Correlation between the two techniques was r =0.4512, (p 0.05).Within-run precision expressed as coefficient of variation (CV) showed that the heat precipitation method had a lower CV of 32.12% compared with dry weight method with a CV of 55 .3% and is more precise (