562 research outputs found

    Interpretation of creep crack growth data for ½ CMV steel weldments

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    Abstract½Cr½ Mo¼ V (½ CMV) steel has been used in high temperature power plant piping due to its enhanced weld properties. Creep crack growth testing has been performed on compact tension C(T) specimens of ½CMV (low alloy ferritic) steel at 540◦C on both parent metal specimens as well as fine and coarse grained heat affected zone (HAZ) specimens, where the initial crack is located within the HAZ. The data has been interpreted using the fracture mechanics parameter C* against the crack growth rate. The creep toughness parameter, Kcmat, is also evaluated for the material. It was seen that, for a given C* value, the fine grained HAZ material generally exhibits higher crack growth rates than the post weld heat treated coarse grained HAZ

    Are Land-use Emissions Scalable with Increasing Corn Ethanol Mandates in the United States?

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    In response to the Renewable Fuel Standard, the U.S. transportation sector now consumes a substantial amount (13.3 billion gallons in 2010) of ethanol. A key motivation for these mandates is to expand the consumption of biofuels in road transportation to both reduce foreign oil dependency and to reduce greenhouse gas (GHG) emissions from the consumption of fossil fuels in transportation. In this paper, we present the impacts of several biofuels expansion scenarios for the U.S. in which scaled increases in the U.S. corn ethanol mandates are modeled to explore the scalability of GHG impacts. The impacts show both expected and surprising results. As expected, the area of land used to grow biofuel crops increases with the size of the policy in the U.S., and some land-use changes occur abroad due to trade in agricultural commodities. Because the land-use changes happen largely in the U.S., there is an increase in U.S. land-use emissions when natural lands are converted to agricultural use in the policy scenarios. Further, the emissions impacts in the U.S. and the rest of the world in these scenarios, including land-use emissions, scale in direct proportion to the size of the U.S. corn ethanol mandates. On the other hand, the land-use emissions that occur in the rest of the world are disproportionately larger per hectare of change due to conversions of more carbon-rich forests to cultivate crops and feed livestock.We gratefully acknowledge the financial support for this work from the U.S. Department of Energy, Office of Science under DE-FG02-94ER61937, the U.S. Environmental Protection Agency under XA-83600001-1 and XA-835055101-2, and other government, industry, and foundation sponsors of the Joint Program on the Science and Policy of Global Change

    Community acquired and post-transfusion hepatitis C is there a difference?

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    We analyzed 77 consecutive hepatitis C antibody positive patients to compare the history, laboratory data and histological features of community acquired (CA) and post-transfusion (PT) hepatitis C. Forty-six patients had CA and 31 PT hepatitis C. Mean age in both groups was same (45.67 vs 46 years). Male to female ratio was 2:1 in the CA group and 1:2.4 in the PT group. Mean duration between jaundice and first presentation was 8.9 years in the CA group and the mean duration between transfusion and first presentation was 9.8 years in PT group. No significant difference was found between two groups in the laboratory data. Liver biopsy was done in 32 patients (19 CA and 13 PT group). Mean histological score for disease activity was 9.3 in both groups, although more (68%) patients in the CA group had cirrhosis with chronic active hepatitis, (CAH) as compared to the PT (54%) group. Hepatitis C is an important cause of CA hepatitis. PT hepatitis C is more common in females because of increased likelihood of receiving transfusion for obstetric and gynaecological reasons. There is no significant difference in the laboratory and histological features between CA and PT hepatitis C

    State-of-the-art clinical assessment of hand function

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    We have assembled a multi-disciplinary team of engineers, surgeons, clinicians and neuroscientists from Johns Hopkins School of Medicine and Western University to develop a new device for assessing hand function. It will be capable of sensitively measuring fingertip forces across all five fingers and along all movement directions. Then we can use this device to develop and validate a clinical hand assessment for patients with brain injuries.https://ir.lib.uwo.ca/brainscanprojectsummaries/1005/thumbnail.jp

    Serum proteins and paraproteins in women with silicone implants and connective tissue disease: a case–control study

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    Prior studies have suggested abnormalities of serum proteins, including paraproteins, in women with silicone implants but did not control for the presence of connective-tissue disease (CTD). This retrospective case–control study, performed in tertiary-care academic centers, assessed possible alterations of serum proteins, including paraproteins, in such a population. Seventy-four women with silicone implants who subsequently developed CTD, and 74 age-matched and CTD-matched women without silicone implants, were assessed in the primary study; other groups were used for additional comparisons. Routine serum protein determinations and high-sensitivity protein electrophoresis and immunofixation electrophoresis were performed for detection of paraproteins. Women with silicone implants, either with or without CTD, had significantly lower serum total protein and α1-globulin, α2-globulin, β-globulin, γ-globulin, and IgG levels compared with those without silicone implants. There was no significant difference, however, in the frequency of paraproteinemia between women with silicone implants and CTD (9.5%) and age-matched and CTD-matched women without silicone implants (5.4%) (odds ratio, 1.82; 95% confidence interval, 0.51–6.45). Paraprotein isotypes were similar in the two groups, and the clinical characteristics of the 13 women with paraproteinemia were comparable with an independent population of 10 women with silicone breast implants, CTD, and previously diagnosed monoclonal gammopathies. In summary, this first comprehensive study of serum proteins in women with silicone implants and CTD found no substantially increased risk of monoclonal gammopathy. Women with silicone implants, however, had unexpectedly low serum globulin and immunoglobulin levels, with or without the subsequent development of CTD. The causes and clinical implications of these findings require further investigation

    Low Resistance Polycrystalline Diamond Thin Films Deposited by Hot Filament Chemical Vapour Deposition

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    Polycrystalline diamond thin films with outgrowing diamond (OGD) grains were deposited onto silicon wafers using a hydrocarbon gas (CH4) highly diluted with H2 at low pressure in a hot filament chemical vapour deposition (HFCVD) reactor with a range of gas flow rates. X-ray diffraction (XRD) and SEM showed polycrystalline diamond structure with a random orientation. Polycrystalline diamond films with various textures were grown and (111) facets were dominant with sharp grain boundaries. Outgrowth was observed in flowerish character at high gas flow rates. Isolated single crystals with little openings appeared at various stages at low gas flow rates. Thus, changing gas flow rates had a beneficial influence on the grain size, growth rate and electrical resistivity. CVD diamond films gave an excellent performance for medium film thickness with relatively low electrical resistivity and making them potentially useful in many industrial applications

    No evidence for motor-recovery-related cortical connectivity changes after stroke using resting-state fMRI

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    It has been proposed that a form of cortical reorganization (changes in functional connectivity between brain areas) can be assessed with resting-state (rs) functional MRI (fMRI). Here, we report a longitudinal data set collected from 19 patients with subcortical stroke and 11 controls. Patients were imaged up to five times over 1 year. We found no evidence, using rs-fMRI, for longitudinal poststroke cortical connectivity changes despite substantial behavioral recovery. These results could be construed as questioning the value of resting-state imaging. Here, we argue instead that they are consistent with other emerging reasons to challenge the idea of motor-recovery-related cortical reorganization poststroke when conceived of as changes in connectivity between cortical areas. NEW & NOTEWORTHY We investigated longitudinal changes in functional connectivity after stroke. Despite substantial motor recovery, we found no differences in functional connectivity patterns between patients and controls, nor any changes over time. Assuming that rs-fMRI is an adequate method to capture connectivity changes between cortical regions after brain injury, these results provide reason to doubt that changes in cortico-cortical connectivity are the relevant mechanism for promoting motor recovery

    Evidence for a subcortical origin of mirror movements after stroke: A longitudinal study

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    Following a stroke, mirror movements are unintended movements that appear in the non-paretic hand when the paretic hand voluntarily moves. Mirror movements have previously been linked to overactivation of sensorimotor areas in the non-lesioned hemisphere. In this study, we hypothesized that mirror movements might instead have a subcortical origin, and are the by-product of subcortical motor pathways upregulating their contributions to the paretic hand. To test this idea, we first characterized the time course of mirroring in 53 first-time stroke patients, and compared it to the time course of activities in sensorimotor areas of the lesioned and non-lesioned hemispheres (measured using functional MRI). Mirroring in the non-paretic hand was exaggerated early after stroke (Week 2), but progressively diminished over the year with a time course that parallelled individuation deficits in the paretic hand. We found no evidence of cortical overactivation that could explain the time course changes in behaviour, contrary to the cortical model of mirroring. Consistent with a subcortical origin of mirroring, we predicted that subcortical contributions should broadly recruit fingers in the non-paretic hand, reflecting the limited capacity of subcortical pathways in providing individuated finger control. We therefore characterized finger recruitment patterns in the non-paretic hand during mirroring. During mirroring, non-paretic fingers were broadly recruited, with mirrored forces in homologous fingers being only slightly larger (1.76 times) than those in non-homologous fingers. Throughout recovery, the pattern of finger recruitment during mirroring for patients looked like a scaled version of the corresponding control mirroring pattern, suggesting that the system that is responsible for mirroring in controls is upregulated after stroke. Together, our results suggest that post-stroke mirror movements in the non-paretic hand, like enslaved movements in the paretic hand, are caused by the upregulation of a bilaterally organized subcortical system
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