5,547 research outputs found
New Innovation Models in Medical AI
In recent years, scientists and researchers have devoted considerable resources to developing medical artificial intelligence (AI) technologies. Many of these technologies—particularly those that resemble traditional medical devices in their functions—have received substantial attention in the legal and policy literature. But other types of novel AI technologies, such as those related to quality improvement and optimizing use of scarce facilities, have been largely absent from the discussion thus far. These AI innovations have the potential to shed light on important aspects of health innovation policy. First, these AI innovations interact less with the legal regimes that scholars traditionally conceive of as shaping medical innovation: patent law, FDA regulation, and health insurance reimbursement. Second, and perhaps related, a different set of innovation stakeholders, including health systems and insurers, are conducting their own research and development in these areas for their own use without waiting for commercial product developers to innovate for them. The activities of these innovators have implications for health innovation policy and scholarship. Perhaps most notably, data possession and control play a larger role in determining capacity to innovate in this space, while the ability to satisfy the quality standards of regulators and payers plays a smaller role relative to more familiar biomedical innovations such as new drugs and devices
New Innovation Models in Medical AI
In recent years, scientists and researchers have devoted considerable resources to developing medical artificial intelligence (AI) technologies. Many of these technologies—particularly those that resemble traditional medical devices in their functions—have received substantial attention in the legal and policy literature. But other types of novel AI technologies, such as those related to quality improvement and optimizing use of scarce facilities, have been largely absent from the discussion thus far. These AI innovations have the potential to shed light on important aspects of health innovation policy. First, these AI innovations interact less with the legal regimes that scholars traditionally conceive of as shaping medical innovation: patent law, FDA regulation, and health insurance reimbursement. Second, and perhaps related, a different set of innovation stakeholders, including health systems and insurers, are conducting their own research and development in these areas for their own use without waiting for commercial product developers to innovate for them. The activities of these innovators have implications for health innovation policy and scholarship. Perhaps most notably, data possession and control play a larger role in determining capacity to innovate in this space, while the ability to satisfy the quality standards of regulators and payers plays a smaller role relative to more familiar biomedical innovations such as new drugs and devices
Glassy behavior induced by geometrical frustration in a hard-core lattice gas model
We introduce a hard-core lattice-gas model on generalized Bethe lattices and
investigate analytically and numerically its compaction behavior. If
compactified slowly, the system undergoes a first-order crystallization
transition. If compactified much faster, the system stays in a meta-stable
liquid state and undergoes a glass transition under further compaction. We show
that this behavior is induced by geometrical frustration which appears due to
the existence of short loops in the generalized Bethe lattices. We also compare
our results to numerical simulations of a three-dimensional analog of the
model.Comment: 7 pages, 4 figures, revised versio
Phenomenological local potentials for \pi^- + ^{12}C scattering from 120 to 766 MeV
Pion-nucleus scattering cross sections are calculated by solving a
Schr\"{o}dinger equation reduced from the Klein-Gordon equation. Local
potentials are assumed, and phenomenological potential parameters are searched
energy-dependently for C system so as to reproduce not only
elastic differential cross sections but also total elastic, reaction and total
cross sections at 13 pion incident energies from 120 to 766 MeV. The real and
imaginary parts of the local potentials thus obtained are shown to satisfy the
dispersion relation. The imaginary part of the potentials as a function of the
pion energy is found to peak near the (1232)-resonance energy. The
strong absorption radius of the pion projectile with incident energies near the
-resonance region is found to be about fm, which is
consistent with previous studies of the region where the decay of the
's takes place in nuclei. The phenomenological local potentials are
then compared with the local potentials exactly phase-shift equivalent to
Kisslinger potentials for pion energies near the -resonance
Disorder Induced Ferromagnetism in Restricted Geometries
We study the influence of on-site disorder on the magnetic properties of the
ground state of the infinite Hubbard model. We find that for one
dimensional systems disorder has no influence, while for two dimensional
systems disorder enhances the spin polarization of the system. The tendency of
disorder to enhance magnetism in the ground state may be relevant to recent
experimental observations of spin polarized ground states in quantum dots and
small metallic grains.Comment: 4 pages, 4 figure
Analysis of self--averaging properties in the transport of particles through random media
We investigate self-averaging properties in the transport of particles
through random media. We show rigorously that in the subdiffusive anomalous
regime transport coefficients are not self--averaging quantities. These
quantities are exactly calculated in the case of directed random walks. In the
case of general symmetric random walks a perturbative analysis around the
Effective Medium Approximation (EMA) is performed.Comment: 4 pages, RevTeX , No figures, submitted to Physical Review E (Rapid
Communication
Self-consistent symmetries in the proton-neutron Hartree-Fock-Bogoliubov approach
Symmetry properties of densities and mean fields appearing in the nuclear
Density Functional Theory with pairing are studied. We consider energy
functionals that depend only on local densities and their derivatives. The most
important self-consistent symmetries are discussed: spherical, axial,
space-inversion, and mirror symmetries. In each case, the consequences of
breaking or conserving the time-reversal and/or proton-neutron symmetries are
discussed and summarized in a tabulated form, useful in practical applications.Comment: 26 RevTex pages, 1 eps figure, 9 tables, submitted to Physical Review
The tensor part of the Skyrme energy density functional. I. Spherical nuclei
We perform a systematic study of the impact of the J^2 tensor term in the
Skyrme energy functional on properties of spherical nuclei. In the Skyrme
energy functional, the tensor terms originate both from zero-range central and
tensor forces. We build a set of 36 parameterizations, which covers a wide
range of the parameter space of the isoscalar and isovector tensor term
coupling constants, with a fit protocol very similar to that of the successful
SLy parameterizations. We analyze the impact of the tensor terms on a large
variety of observables in spherical mean-field calculations, such as the
spin-orbit splittings and single-particle spectra of doubly-magic nuclei, the
evolution of spin-orbit splittings along chains of semi-magic nuclei, mass
residuals of spherical nuclei, and known anomalies of charge radii. Our main
conclusion is that the currently used central and spin-orbit parts of the
Skyrme energy density functional are not flexible enough to allow for the
presence of large tensor terms.Comment: 38 pages, 36 figures; Minor correction
Quasi-chemical Theories of Associated Liquids
It is shown how traditional development of theories of fluids based upon the
concept of physical clustering can be adapted to an alternative local
clustering definition. The alternative definition can preserve a detailed
valence description of the interactions between a solution species and its
near-neighbors, i.e., cooperativity and saturation of coordination for strong
association. These clusters remain finite even for condensed phases. The
simplest theory to which these developments lead is analogous to quasi-chemical
theories of cooperative phenomena. The present quasi-chemical theories require
additional consideration of packing issues because they don't impose lattice
discretizations on the continuous problem. These quasi-chemical theories do not
require pair decomposable interaction potential energy models. Since
calculations may be required only for moderately sized clusters, we suggest
that these quasi-chemical theories could be implemented with computational
tools of current electronic structure theory. This can avoid an intermediate
step of approximate force field generation.Comment: 20 pages, no figures replacement: minor typographical corrections,
four references added, in press Molec. Physics 199
Collective Modes of Tri-Nuclear Molecules
A geometrical model for tri-nuclear molecules is presented. An analytical
solution is obtained provided the nuclei, which are taken to be prolately
deformed, are connected in line to each other. Furthermore, the tri-nuclear
molecule is composed of two heavy and one light cluster, the later sandwiched
between the two heavy clusters. A basis is constructed in which Hamiltonians of
more general configurations can be diagonalized. In the calculation of the
interaction between the clusters higher multipole deformations are taken into
account, including the hexadecupole one. A repulsive nuclear core is introduced
in the potential in order to insure a quasi-stable configuration of the system.
The model is applied to three nuclear molecules, namely Sr + Be +
Ba, Mo + Be + Te and Ru + Be +
Sn.Comment: 24 pages, 9 figure
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