Ferromagnetic phase transition and Bose-Einstein condensation in spinor Bose gases

Phase transitions in spinor Bose gases with ferromagnetic (FM) couplings are studied via mean-field theory. We show that an infinitesimal value of the coupling can induce a FM phase transition at a finite temperature always above the critical temperature of Bose-Einstein condensation. This contrasts sharply with the case of Fermi gases, in which the Stoner coupling $I_s$ can not lead to a FM phase transition unless it is larger than a threshold value $I_0$. The FM coupling also increases the critical temperatures of both the ferromagnetic transition and the Bose-Einstein condensation.Comment: 4 pages, 4 figure

J/Psi Suppression in Heavy Ion Collisions at the CERN SPS

We reexamine the production of J/Psi and other charmonium states for a variety of target-projectile choices at the SPS. For this study we use a newly constructed cascade code LUCIFER II, which yields acceptable descriptions of both hard and soft processes, specifically Drell-Yan and hidden charm production, and soft energy loss and meson production, at the SPS. Glauber calculations of other authors are redone, and compared directly to the cascade results. The modeling of the charmonium states differs from that of earlier workers in its unified treatment of the hidden charm meson spectrum, which is introduced from the outset as a set of coupled states. The result is a description of the NA38 and NA50 data in terms of a conventional hadronic picture. The apparently anomalous suppression found in the most massive Pb+Pb system arises from three sources: destruction in the initial nucleon-nucleon cascade, use of coupled channels to exploit the larger breakup in the less bound Chi and Psi' states, and comover interaction in the final low energy phase.Comment: 36 pages (15 figures

Tunneling of quantum rotobreathers

We analyze the quantum properties of a system consisting of two nonlinearly coupled pendula. This non-integrable system exhibits two different symmetries: a permutational symmetry (permutation of the pendula) and another one related to the reversal of the total momentum of the system. Each of these symmetries is responsible for the existence of two kinds of quasi-degenerated states. At sufficiently high energy, pairs of symmetry-related states glue together to form quadruplets. We show that, starting from the anti-continuous limit, particular quadruplets allow us to construct quantum states whose properties are very similar to those of classical rotobreathers. By diagonalizing numerically the quantum Hamiltonian, we investigate their properties and show that such states are able to store the main part of the total energy on one of the pendula. Contrary to the classical situation, the coupling between pendula necessarily introduces a periodic exchange of energy between them with a frequency which is proportional to the energy splitting between quasi-degenerated states related to the permutation symmetry. This splitting may remain very small as the coupling strength increases and is a decreasing function of the pair energy. The energy may be therefore stored in one pendulum during a time period very long as compared to the inverse of the internal rotobreather frequency.Comment: 20 pages, 11 figures, REVTeX4 styl

Exchange and the Coulomb blockade: Peak height statistics in quantum dots

We study the effect of the exchange interaction on the Coulomb blockade peak height statistics in chaotic quantum dots. Because exchange reduces the level repulsion in the many body spectrum, it strongly affects the fluctuations of the peak conductance at finite temperature. We find that including exchange substantially improves the description of the experimental data. Moreover, it provides further evidence of the presence of high spin states (S>1) in such systems.Comment: 5 pages, 4 figures. Published version, title change

Observation of hard scattering in photoproduction events with a large rapidity gap at HERA

Events with a large rapidity gap and total transverse energy greater than 5 GeV have been observed in quasi-real photoproduction at HERA with the ZEUS detector. The distribution of these events as a function of the $\gamma p$ centre of mass energy is consistent with diffractive scattering. For total transverse energies above 12 GeV, the hadronic final states show predominantly a two-jet structure with each jet having a transverse energy greater than 4 GeV. For the two-jet events, little energy flow is found outside the jets. This observation is consistent with the hard scattering of a quasi-real photon with a colourless object in the proton.Comment: 19 pages, latex, 4 figures appended as uuencoded fil

Structure–activity Relationships of Amyloid Beta-aggregation Inhibitors Based on Curcumin: Influence of Linker Length and Flexibility

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/66293/1/j.1747-0285.2007.00557.x.pd

A de novo paradigm for male infertility

Funding Information: (DFG, CRU326) to C.F. and F.T. This project was also supported in part by funding from the Australian National Health and Medical Research Council (APP1120356) to M.K.O.B., by grants from the National Institutes of Health of the United States of America (R01HD078641 to D.F.C. and K.I.A., P50HD096723 to D.F.C.) and from the Biotechnology and Biological Sciences Research Council (BB/S008039/1) to D.J.E. Funding Information: We are grateful for the participation of all patients and their parents in this study. We thank Laurens van de Wiel (Radboudumc), Sebastian Judd-Mole (Monash University), Arron Scott and Bryan Hepworth (Newcastle University) for technical support, and Margot J Wyrwoll (University of Münster) for help with handling MERGE samples and data. This project was funded by The Netherlands Organization for Scientific Research (918-15-667) to J.A.V. as well as an Investigator Award in Science from the Wellcome Trust (209451) to J.A.V. a grant from the Catherine van Tussenbroek Foundation to M.S.O. a grant from MERCK to R.S. a UUKi Rutherford Fund Fellowship awarded to B.J.H. and the German Research Foundation Clinical Research Unit “Male Germ Cells” Publisher Copyright: © 2022, The Author(s).De novo mutations are known to play a prominent role in sporadic disorders with reduced fitness. We hypothesize that de novo mutations play an important role in severe male infertility and explain a portion of the genetic causes of this understudied disorder. To test this hypothesis, we utilize trio-based exome sequencing in a cohort of 185 infertile males and their unaffected parents. Following a systematic analysis, 29 of 145 rare (MAF < 0.1%) protein-altering de novo mutations are classified as possibly causative of the male infertility phenotype. We observed a significant enrichment of loss-of-function de novo mutations in loss-of-function-intolerant genes (p-value = 1.00 × 10−5) in infertile men compared to controls. Additionally, we detected a significant increase in predicted pathogenic de novo missense mutations affecting missense-intolerant genes (p-value = 5.01 × 10−4) in contrast to predicted benign de novo mutations. One gene we identify, RBM5, is an essential regulator of male germ cell pre-mRNA splicing and has been previously implicated in male infertility in mice. In a follow-up study, 6 rare pathogenic missense mutations affecting this gene are observed in a cohort of 2,506 infertile patients, whilst we find no such mutations in a cohort of 5,784 fertile men (p-value = 0.03). Our results provide evidence for the role of de novo mutations in severe male infertility and point to new candidate genes affecting fertility.publishersversionpublishe