116 research outputs found

    Genomic DNA transposition induced by human PGBD5

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    Transposons are mobile genetic elements that are found in nearly all organisms, including humans. Mobilization of DNA transposons by transposase enzymes can cause genomic rearrangements, but our knowledge of human genes derived from transposases is limited. In this study, we find that the protein encoded by human PGBD5, the most evolutionarily conserved transposable element-derived gene in vertebrates, can induce stereotypical cut-and-paste DNA transposition in human cells. Genomic integration activity of PGBD5 requires distinct aspartic acid residues in its transposase domain, and specific DNA sequences containing inverted terminal repeats with similarity to piggyBac transposons. DNA transposition catalyzed by PGBD5 in human cells occurs genome-wide, with precise transposon excision and preference for insertion at TTAA sites. The apparent conservation of DNA transposition activity by PGBD5 suggests that genomic remodeling contributes to its biological function

    On non-local variational problems with lack of compactness related to non-linear optics

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    We give a simple proof of existence of solutions of the dispersion manage- ment and diffraction management equations for zero average dispersion, respectively diffraction. These solutions are found as maximizers of non-linear and non-local vari- ational problems which are invariant under a large non-compact group. Our proof of existence of maximizer is rather direct and avoids the use of Lions' concentration compactness argument or Ekeland's variational principle.Comment: 30 page

    Photon data shed new light upon the GDR spreading width in heavy nuclei

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    A global study of the electric dipole strength in and below the isovector giant dipole resonance (GDR) is presented for mass numbers A>80. It relies on the recently established remarkably good match between data for the nuclear photo effect to novel photon scattering data covering the region below the neutron emission threshold as well as by average resonance neutron capture (ARC). From the wide energy coverage of these data the correlation of the GDR spreading width with energy can be studied with remarkable accuracy. A clear sensitivity to details of the nuclear shape, i.e. the beta- and gamma-deformations, is demonstrated. Based hereon a new parameterization of the energy dependence of the nuclear electric-dipole strength is proposed which - with only two new parameters - allows to describe the dipole strength in all heavy nuclei with A>80. Although it differs significantly from previous parameterizations it holds for spherical, transitional, triaxial and well deformed nuclei. The GDR spreading width depends in a regular way on the respective resonance energy, but it is independent of the photon energy.Comment: accepted by Phys. Lett. B after minor modification

    The Parallel Magnetoconductance of Interacting Electrons in a Two Dimensional Disordered System

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    The transport properties of interacting electrons for which the spin degree of freedom is taken into account are numerically studied for small two dimensional diffusive clusters. On-site electron-electron interactions tend to delocalize the electrons, while long-range interactions enhance localization. On careful examination of the transport properties, we reach the conclusion that it does not show a two dimensional metal insulator transition driven by interactions. A parallel magnetic field leads to enhanced resistivity, which saturates once the electrons become fully spin polarized. The strength of the magnetic field for which the resistivity saturates decreases as electron density goes down. Thus, the numerical calculations capture some of the features seen in recent experimental measurements of parallel magnetoconductance.Comment: 10 pages, 6 figure

    Exotic ρ±ρ0\rho^\pm\rho^0 state photoproduction

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    It is shown that the list of unusual mesons planned for a careful study in photoproduction can be extended by the exotic states X±(1600)X^\pm(1600) with IG(JPC)=2+(2++)I^G(J ^{PC})=2^+(2^{++}) which should be looked for in the ρ±ρ0\rho^\pm\rho^0 decay channels in the reactions ÎłN→ρ±ρ0N\gamma N\to\rho^\pm\rho^0N and ÎłN→ρ±ρ0Δ\gamma N\to\rho^\pm \rho^0\Delta. The full classification of the ρ±ρ0\rho^\pm\rho^0 states by their quantum numbers is presented. A simple model for the spin structure of the Îłp→f2(1270)p \gamma p\to f_2(1270)p, Îłp→a20(1320)p\gamma p\to a^0_2(1320)p, and ÎłN→X±(N,Δ)\gamma N\to X^\pm (N, \Delta) reaction amplitudes is formulated and the tentative estimates of the corresponding cross sections at the incident photon energy Eγ≈6E_\gamma\approx 6 GeV are obtained: σ(Îłp→f2(1270)p)≈0.12\sigma(\gamma p\to f_2(1270)p)\approx0.12 ÎŒ\mub, σ(Îłp→a20(1320)p)≈0.25 \sigma(\gamma p\to a^0_2(1320)p)\approx0.25 ÎŒ\mub, σ(ÎłN→X±N→ρ±ρ0N)≈0.018\sigma(\gamma N\to X^\pm N\to\rho^\pm\rho^0N)\approx0.018 ÎŒ\mub, and σ(Îłp→X−Δ++→ρ−ρ0Δ++)≈0.031\sigma(\gamma p\to X^-\Delta^{++ }\to\rho^-\rho^0\Delta^{++})\approx0.031 ÎŒ\mub. The problem of the X±X^\pm signal extraction from the natural background due to the other π±π0π+π−\pi^\pm\pi^0 \pi^+\pi^- production channels is discussed. In particular the estimates are presented for the Îłp→h1(1170)π+n\gamma p\to h_1(1170)\pi^+n, Îłp→ρâ€Č+n→π+π0π+π−n\gamma p\to\rho'^{+}n\to \pi^+\pi^0\pi^+\pi^-n, and Îłp→ωρ0p\gamma p\to\omega\rho^0p reaction cross sections. Our main conclusion is that the search for the exotic X±(2+(2++))X^\pm(2^+(2^{++})) states is quite feasible at JEFLAB facility. The expected yield of the ÎłN→X±N→ρ±ρ0N\gamma N\to X^\pm N\to\rho^\pm\rho^0N events in a 30-day run at the 100% detection efficiency approximates 2.8×1062.8\times10^6 events.Comment: 19 pages, revtex, 1 figure in postscipt, some comments and references added, a few minor typos corrected, to be published in Phys. Rev.

    ATLAS detector and physics performance: Technical Design Report, 1

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