In vitro immunosuppressive effects of FR 900506 on human T lymphocyte alloactivation

FR 900506 (FR) is a new immunosuppressive drug which prolongs allograft survival. Our studies have compared the in vitro inhibitory effects of FR and cyclosporine (CsA) on human lymphocyte proliferation. Considerably lower doses of FR were required to induce inhibition of lymphocyte proliferation induced by concanavalin A (Con A) stimulation or in primary mixed lymphocyte reactions (MLR). Similar differences between FR and CsA were observed with the secondary stimulation of alloactivated T cells generated in MLR or propagated from liver transplant biopsies. These observations provide further evidence that FR is about 500 fold more potent than CsA and may be a useful immunosuppressive agent in organ transplantation

Induction of graft acceptance after dog kidney or liver transplantation

We have reported that, a short delayed course of intramuscular FK 506 can induce a,donor strain-specific immunologic unresponsiveness to cardiac allograft in rats.1 Further studies have been performed to determine if this agent can induce graft acceptance after canine renal (KT) or hepatic (OLT) allotransplantation. Preliminary descriptions of these efforts have been published.

Vacuum polarization in muonic and antiprotonic atoms: the fine structure at medium Z

Effects of vacuum polarization modify the energy levels in atoms with an orbiting particle heavier than an electron. The dominant effect is due to the Uehling potential. In this paper we consider the relativistic corrections to the energy levels caused by the Uehling potential and in particular the fine structure in muonic and antiprotonic atoms. We derive general expressions and consider in detail specific regions of parameters which allow simple asymptotic expansion. We take into account the recoil effects and anomalous magnetic moment in the case of an antiproton as the orbiting particle

Electromagnetic corrections to π−\pi ^-p scattering length from pionic hydrogen

We derive a closed, model space independent, expression for the electromagnetic correction factor $\delta$ to the scattering length $a$ extracted from a hydrogenic atom with an extended charge to order $\alpha ^2$ and $a^3$ in the limit of a short ranged hadronic interaction.Comment: 4 pages; PANIC02, XVIth Conference on Particles and Nuclei, Osaka, to appear in Nuclear Physics