Nadroparine-induced skin necrosis on a patient with essential thrombocythaemia: a case report

Skin necrosis is a rare but serious complication of subcutaneously administered low-molecular-weight heparin. We report a case of a 53-year-old female patient with skin necrosis induced by subcutaneous administration of nadroparine. The patient suffered from essential thrombocythaemia on a background of chronic myeloproliferative disease. She was admitted to our clinic with a subacute ileus due to endometriosis of the rectosigmoid junction. She underwent a high anterior resection and she received pre- and postoperative antithrombotic prophylaxis with subcutaneous nadroparine on a daily basis. On the 6th and 7th postoperative days, two skin necroses occurred at two injection sites

Higher weight and weight gain after 4 years of age rather than weight at birth are associated with adiposity, markers of glucose metabolism, and blood pressure in 5-year-old Ethiopian children

BACKGROUND: Fetal and early life growth is associated with adult risk of obesity and cardiometabolic disease. However, little is known about the relative importance of birth weight and successive periods of weight gain on markers of cardiometabolic risk in childhood in low-income populations. // OBJECTIVES: The objective was to study associations of birth weight and weight gain velocities in selected age intervals from birth to 60 mo with height, fat-free mass (FFM), and markers of adiposity and cardiometabolic risk at 60 mo. // METHODS: In a prospective cohort study of 375 Ethiopian children aged 60 mo, we estimated individual weight gain velocities in the periods between birth and 3, 6, 24, 48, and 60 mo using linear-spline mixed-effects modeling. Subsequently, we analyzed associations of birth weight, weight gain velocities, and current weight with height, FFM, and markers of adiposity and cardiometabolic risk. // RESULTS: Weight gain from 48 to 60 mo and weight at 60 mo rather than birth weight were the strongest correlates of insulin, C-peptide, HOMA-IR, blood pressure, height, FFM, waist circumference, and fat mass at 60 mo. For instance, 1 SD higher (1 SD = 50 g/mo) weight accretion from 48 to 60 mo was associated with a higher insulin of 23.3% (95% CI: 9.6%, 38.8%), C-peptide of 11.4% (2.7%, 20.8%), systolic blood pressure of 1.4 mm Hg (0.6, 2.3 mm Hg), fat mass of 0.72 kg (0.59, 0.85 kg), and FFM of 0.70 kg (0.56, 0.85 kg). Weight gain from 0 to 3 mo was positively associated with LDL cholesterol, systolic blood pressure, height, and the body composition indices, and weight gain from 24 to 48 mo was inversely associated with blood glucose. // CONCLUSIONS: In 60-mo-old Ethiopian urban children, weight gain and weight after 48 mo rather than weight at birth may represent a sensitive period for variations in markers of adiposity and glucose metabolism. The birth cohort is registered at https://www.isrctn.com/ as ISRCTN46718296

Performance pay and assortative matching

Peer reviewedPostprin

Making it your own by adapting it to what’s important to you”: Plurilingual Critical Literacies to promote L2 Japanese users’ sense of ownership of Japanese

The dichotomy between native speaker (NS) and non-native speaker (NNS) remains ubiquitous across different language-learning contexts despite increasing mobility and multilingualism of society. L2 Japanese learners in particular may find themselves positioned as subordinate to NSs because of the myth of Japan being a homogeneous nation of one race and one language. To help L2 Japanese students counter such positioning and gain a sense of ownership, we implemented “plurilingual critical literacies” in a Japanese language course in the U.S. Critical literacy aims to cultivate students’ awareness that power relationships are at play in language use, and plurilingual pedagogy valorizes students’ multilingual resources. Eleven high-intermediate-level Japanese students mobilized their linguistic and cultural resources to read and discuss authentic texts by transcultural or “culturally mobile” writers (Dagnino 2015). These writers expressed resistance to the status quo and made meaning creatively, as mediators between two languages and cultures. Reading, analyzing, and discussing texts by transcultural writers motivated students to counter ideologies of NS superiority, and to own Japanese in the ways that best suited their transcultural identities

Impact of Sentence length on the Readability of Web for Screen Reader Users

Readability of text is generally believed to be connected to sentence length. Most studies on readability are based on visual reading. Less is known about text readability for users relying on screen readers, such as users who are blind. This study therefore set out to investigate the effect of sentence length on the readability of web texts accessed using screen readers. A controlled within-subjects experiment was performed with twenty-one participants. Participants used a screen reader to read five texts with different sentence lengths. The par-ticipants’ comprehension and perceived workload were measured. The findings reveal that there is a significant effect of sentence length and most participants exhibit the highest comprehension and lowest workload with sentences compris-ing 16-20 words. Implications of these results are that web content providers should strive for sentence length of 16-20 words to maximize readability

Rehabilitation and Product Design: Towards the Inclusion of People with Disabilities Through Interdisciplinary Collaboration

In low-GDP countries, such as Brazil, many older people and people with disabilities rely on the public health system for access to assistive devices, which are important to support them to live healthy and dignified lives. However, many problems limit their access to specialized prescriptions and appropriate devices that satisfy their needs and expectations. This paper explores the challenges, contributions and results from an interdisciplinary collaboration between two different yet related areas of knowledge – Product Design and Rehabilitation – in education, research and innovation in assistive technologies. The combination of product design education and rehabilitation services has mutual benefits from the perspective of research and innovation, thus contributing for the community. Here, we report on the process and benefits resulting from four years of interdisciplinary collaboration on assistive products for the aging population and people with disabilities