Introduction of Center for Comparative Medicine, Hyogo College of Medicine based on concept of laboratory animal allergy prevention

Laboratory animal allergy (LAA) is an important problem on considering the occupational safety and health of animal workers. The Center for Comparative Medicine (CCOM), Hyogo College of Medicine, opened on April 1, 2018, is an animal experiment facility designed and constructed based on the concept of LAA prevention. This CCOM is located on the first and second floors of a newly built "education· research building". Methods for the prevention of LAA are airflow control by air conditioning equipment, breeding equipment, experimental equipment, cage transporters that suppress the diffusion of aero allergens, spraying of slightly acidic water mist, and prevention of allergen exposure by the strict use of Personal Protective Equipment (PPE). In addition, we implemented training on LAA and take measures to prevent office workers from being exposed to laboratory animal-derived allergens

Evaluation of Availability of New Experiment Technique for Cervical Spinal Cavity Administration in Rats -Examination by Behavioral Pharmacological Study of Inducing Anesthetic Potentiation-

ラットの硬･クモ膜下腔内への投与方法としては､従来からカテーテル設置による大槽内投与法が汎用されている｡しかし､これらの大槽内投与法は､投与前に手術などの事前処置や回復の時間が必要なことなどの制約があるため,速やかに投与を開始することや短時間に多数のラットへ投与することなどが困難である｡そこで､我々はラットの後頭部から経皮的に頚部髄腔内へ穿針する投与法である頚部髄腔内投与法を開発した｡今回は､その有用性を麻酔薬や催眠導入剤のスクリーニングに用いられる麻酔増強作用により検討を行った｡麻酔増強作用は塩酸ケタミンならびにペントバルビタールナトリウムを用いて､チオペンタールナトリウム麻酔増強作用により行った｡その結果､頚部髄腔内投与法は大槽内投与法に比べ､ストレス無く投与できること｡すでに汎用されている大槽内投与法投と同様の薬理学的評価が得られた事などから､頚部髄腔内投与法は大槽内投与法に代わるラットの硬･クモ膜下腔内への投与方法としての可能性が示唆された

Introduction of Center for Comparative Medicine, Hyogo College of Medicine based on concept of laboratory animal allergy prevention

Laboratory animal allergy (LAA) is an important problem on considering the occupational safety and health of animal workers. The Center for Comparative Medicine (CCOM), Hyogo College of Medicine, opened on April 1, 2018, is an animal experiment facility designed and constructed based on the concept of LAA prevention. This CCOM is located on the first and second floors of a newly built "education· research building". Methods for the prevention of LAA are airflow control by air conditioning equipment, breeding equipment, experimental equipment, cage transporters that suppress the diffusion of aero allergens, spraying of slightly acidic water mist, and prevention of allergen exposure by the strict use of Personal Protective Equipment (PPE). In addition, we implemented training on LAA and take measures to prevent office workers from being exposed to laboratory animal-derived allergens