196 research outputs found
A quasi classical approach to fully differential ionization cross sections
A classical approximation to time dependent quantum mechanical scattering in
the M\o{}ller formalism is presented. Numerically, our approach is similar to a
standard Classical-Trajectory-Monte-Carlo calculation. Conceptually, however,
our formulation allows one to release the restriction to stationary initial
distributions. This is achieved by a classical forward-backward propagation
technique. As a first application and for comparison with experiment we present
fully differential cross sections for electron impact ionization of atomic
hydrogen in the Erhardt geometry.Comment: 6 pages, 2 figure
Secondary malignant neoplasms, progression-free survival and overall survival in patients treated for Hodgkin lymphoma: A systematic review and meta-analysis of randomized clinical trials
Treatment intensification to maximize disease control and reduced intensity approaches to minimize the risk of late sequelae have been evaluated in newly diagnosed Hodgkin lymphoma. The influence of these interventions on the risk of secondary malignant neoplasms, progression-free survival and overall survival is reported in the meta-analysis herein, based on individual patient data from 9498 patients treated within 16 randomized controlled trials for newly diagnosed Hodgkin lymphoma between 1984 and 2007. Secondary malignant neoplasms were meta-analyzed using Peto’s method as time-to-event outcomes. For progression-free and overall survival, hazard ratios derived from each trial using Cox regression were combined by inverse-variance weighting. Five study questions (combined-modality treatment vs. chemotherapy alone; more extended vs. involved-field radiotherapy; radiation at higher doses vs. radiation at 20 Gy; more vs. fewer cycles of the same chemotherapy protocol; standard-dose chemotherapy vs. intensified chemotherapy) were investigated. After a median follow-up of 7.4 years, dose-intensified chemotherapy resulted in better progression-free survival rates (P=0.007) as compared with standard-dose chemotherapy, but was associated with an increased risk of therapy-related acute myeloid leukemia/myelodysplastic syndromes (P=0.0028). No progression-free or overall survival differences were observed between combined-modality treatment and chemotherapy alone, but more secondary malignant neoplasms were seen after combined-modality treatment (P=0.010). For the remaining three study questions, outcomes and secondary malignancy rates did not differ significantly between treatment strategies. The results of this meta-analysis help to weigh up efficacy and secondary malignancy risk for the choice of first-line treatment for Hodgkin lymphoma patients. However, final conclusions regarding secondary solid tumors require longer follow-up
A semi-classical over-barrier model for charge exchange between highly charged ions and one-optical electron atoms
Absolute total cross sections for electron capture between slow, highly
charged ions and alkali targets have been recently measured. It is found that
these cross sections follow a scaling law with the projectile charge which is
different from the one previously proposed basing on a classical over-barrier
model (OBM) and verified using rare gases and molecules as targets. In this
paper we develop a "semi-classical" (i.e. including some quantal features) OBM
attempting to recover experimental results. The method is then applied to
ion-hydrogen collisions and compared with the result of a sophisticated
quantum-mechanical calculation. In the former case the accordance is very good,
while in the latter one no so satisfactory results are found. A qualitative
explanation for the discrepancies is attempted.Comment: RevTeX, uses epsf; 6 pages text + 3 EPS figures Journal of Physics B
(scehduled March 2000). This revision corrects fig.
Hurst's Rescaled Range Statistical Analysis for Pseudorandom Number Generators used in Physical Simulations
The rescaled range statistical analysis (R/S) is proposed as a new method to
detect correlations in pseudorandom number generators used in Monte Carlo
simulations. In an extensive test it is demonstrated that the RS analysis
provides a very sensitive method to reveal hidden long run and short run
correlations. Several widely used and also some recently proposed pseudorandom
number generators are subjected to this test. In many generators correlations
are detected and quantified.Comment: 12 pages, 12 figures, 6 tables. Replaces previous version to correct
citation [19
Ion Collisions in Very Strong Electric Fields
A Classical Trajectory Monte Carlo (CTMC) simulation has been made of
processes of charge exchange and ionization between an hydrogen atom and fully
stripped ions embedded in very strong static electric fields (
V/m), which are thought to exist in cosmic and laser--produced plasmas.
Calculations show that the presence of the field affects absolute values of the
cross sections, enhancing ionization and reducing charge exchange. Moreover,
the overall effect depends upon the relative orientation between the field and
the nuclear motion. Other features of a null-field situation, such as scaling
laws, are revisited.Comment: Latex, 13 pages, 11 figures (available upon request), to be published
in Journal of Physics
Quasiclassical double photoionization from the 2^{1,3}S excited states of helium including shakeoff
We account for the different symmetries of the 2^{1,3}S helium excited states
in a quasiclassical description of the knockout mechanism augmented by a
quantum shakeoff contribution. We are thus able to formulate the separate
contribution of the knockout and shakeoff mechanisms for double photoionization
for any excess energy from the 2^{1,3}S states. Photoionization ratios and
singly differential cross sections calculated for the 2^{1,3}S excited states
of helium are found to be in very good agreement with recent theoretical
results.Comment: 9 pages, 5 figure
Electron impact double ionization of helium from classical trajectory calculations
With a recently proposed quasiclassical ansatz [Geyer and Rost, J. Phys. B 35
(2002) 1479] it is possible to perform classical trajectory ionization
calculations on many electron targets. The autoionization of the target is
prevented by a M\o{}ller type backward--forward propagation scheme and allows
to consider all interactions between all particles without additional
stabilization. The application of the quasiclassical ansatz for helium targets
is explained and total and partially differential cross sections for electron
impact double ionization are calculated. In the high energy regime the
classical description fails to describe the dominant TS1 process, which leads
to big deviations, whereas for low energies the total cross section is
reproduced well. Differential cross sections calculated at 250 eV await their
experimental confirmation.Comment: LaTeX, 22 pages, 10 figures, submitted to J. Phys.
Density of Superfluid Helium Droplets
The classical integral cross sections of large superfluid 4He_N droplets and
the number of atoms in the droplets (N=10^3-10^4) have been measured in
molecular beam scattering experiments. These measurements are found to be in
good agreement with the cross sections predicted from density functional
calculations of the radial density distributions with a 10-90 % surface
thickness of 5.7\AA. By using a simple model for the density profile of the
droplets a thickness of about 6-8\AA is extracted directly from the data.Comment: 27 pages, REVTeX, 5 postscript figure
A quasi classical approach to electron impact ionization
A quasi classical approximation to quantum mechanical scattering in the
Moeller formalism is developed. While keeping the numerical advantage of a
standard Classical--Trajectory--Monte--Carlo calculation, our approach is no
longer restricted to use stationary initial distributions. This allows one to
improve the results by using better suited initial phase space distributions
than the microcanonical one and to gain insight into the collision mechanism by
studying the influence of different initial distributions on the cross section.
A comprehensive account of results for single, double and triple differential
cross sections for atomic hydrogen will be given, in comparison with experiment
and other theories.Comment: 21 pages, 10 figures, submitted to J Phys
Fertility and gonadal function in female survivors after treatment of early unfavorable Hodgkin lymphoma (HL) within the German Hodgkin Study Group HD14 trial
Background In the HD14 trial, 2× BEACOPPescalated+2× ABVD (2+2) has improved the primary outcome. Compared with 4× ABVD, this benefit might be compromised by more infertility in women. Therefore, we analyzed gonadal function and fertility. Patients and methods Women ≤45 years in ongoing remission at least 1 year after therapy were included. Hormone parameters, menopausal symptoms, measures to preserve fertility, menstrual cycle, pregnancies, and offspring were evaluated. Results Three hundred and thirty one of 579 women addressed participated (57.2%) and 263 per-protocol treated patients qualified (A=ABVD: 137, B=2+2: 126, mean time after therapy 42 and 43 months, respectively). Regular menstrual cycle after treatment (A: 87%, B: 83%) and time to recovery (≤12 months) were not different. Follicle-stimulating hormone and anti-Muellerian hormone were significantly better in arm A. However, pregnancies after therapy favored arm B (A: 15%, B: 26%, P=0.043) and motherhood rates were equivalent to the German normal population. Multivariate analysis revealed prophylactic use of gonadotropin-releasing hormone (GnRH) analogues as highly significant prognostic factor for preservation of fertility (odds ratio=12.87, P=0.001). Severe menopausal symptoms were frequent in women ≥30 years (A: 21%, B: 25%). Conclusions Hormonal levels after 2+2 indicate a reduced ovarian reserve. However, 2+2 in combination with GnRH analogues does not compromise fertility within the evaluated observation tim
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