Hard Decision Cooperative Spectrum Sensing Based on Estimating the Noise Uncertainty Factor

Spectrum Sensing (SS) is one of the most challenging issues in Cognitive Radio (CR) systems. Cooperative Spectrum Sensing (CSS) is proposed to enhance the detection reliability of a Primary User (PU) in fading environments. In this paper, we propose a hard decision based CSS algorithm using energy detection with taking into account the noise uncertainty effect. In the proposed algorithm, two dynamic thresholds are toggled based on predicting the current PU activity, which can be successfully expected using a simple successive averaging process with time. Also, their values are evaluated using an estimated value of the noise uncertainty factor. These dynamic thresholds are used to compensate the noise uncertainty effect and increase (decrease) the probability of detection (false alarm), respectively. Theoretical analysis is performed on the proposed algorithm to deduce its enhanced false alarm and detection probabilities compared to the conventional hard decision CSS. Moreover, simulation analysis is used to confirm the theoretical claims and prove the high performance of the proposed scheme compared to the conventional CSS using different fusion rules.Comment: 5 pages, 4 figures, IEEE International Conference on Computer Engineering and Systems (ICCES 2015). arXiv admin note: text overlap with arXiv:1505.0558

Soft Decision Cooperative Spectrum Sensing Based Upon Noise Uncertainty Estimation

Spectrum Sensing (SS) constitutes the most critical task i n Cognitive Radio (CR) systems for Primary User (PU) detection. Cooperative Spectrum Sensing (CSS) is introduced to enhance the detection reliability of the PU in fading environments. In this paper, we propose a soft decision based CSS algorithm using energy detection by taking into account the noise uncertainty effect. In the proposed algorithm, two threshold levels are utilized based on predicting the current PU activity, which can be successfully expected using a simple successive averaging process with time. The two threshold levels are evaluated based on estimating the noise uncertainty factor. In addition, they are toggled in a dynamic manner to compensate the noise uncertainty effect and to increase the probability of detection and decrease the probability of false alarm. Theoretical analysis is performed on the proposed algorithm to evaluate its enhanced false alarm and detection probabilities over the conventional soft decision CSS using different combining schemes. In addition, simulation results show the high efficiency of the proposed scheme compared to the conventional soft decision CSS, with high computational complexity enhancements.Comment: 6 Pages, 5 Figures, ICC workshops 201

Metal-Bound Methisazone; Novel Drugs Targeting Prophylaxis and Treatment of SARS-CoV-2, a Molecular Docking Study.

SARS-CoV-2 currently lacks effective first-line drug treatment. We present promising data from in silico docking studies of new Methisazone compounds (modified with calcium, Ca; iron, Fe; magnesium, Mg; manganese, Mn; or zinc, Zn) designed to bind more strongly to key proteins involved in replication of SARS-CoV-2. In this in silico molecular docking study, we investigated the inhibiting role of Methisazone and the modified drugs against SARS-CoV-2 proteins: ribonucleic acid (RNA)-dependent RNA polymerase (RdRp), spike protein, papain-like protease (PlPr), and main protease (MPro). We found that the highest binding interactions were found with the spike protein (6VYB), with the highest overall binding being observed with Mn-bound Methisazone at -8.3 kcal/mol, followed by Zn and Ca at -8.0 kcal/mol, and Fe and Mg at -7.9 kcal/mol. We also found that the metal-modified Methisazone had higher affinity for PlPr and MPro. In addition, we identified multiple binding pockets that could be singly or multiply occupied on all proteins tested. The best binding energy was with Mn-Methisazone versus spike protein, and the largest cumulative increases in binding energies were found with PlPr. We suggest that further studies are warranted to identify whether these compounds may be effective for treatment and/or prophylaxis

Burnout among surgeons before and during the SARS-CoV-2 pandemic: an international survey

Background: SARS-CoV-2 pandemic has had many significant impacts within the surgical realm, and surgeons have been obligated to reconsider almost every aspect of daily clinical practice. Methods: This is a cross-sectional study reported in compliance with the CHERRIES guidelines and conducted through an online platform from June 14th to July 15th, 2020. The primary outcome was the burden of burnout during the pandemic indicated by the validated Shirom-Melamed Burnout Measure. Results: Nine hundred fifty-four surgeons completed the survey. The median length of practice was 10 years; 78.2% included were male with a median age of 37 years old, 39.5% were consultants, 68.9% were general surgeons, and 55.7% were affiliated with an academic institution. Overall, there was a significant increase in the mean burnout score during the pandemic; longer years of practice and older age were significantly associated with less burnout. There were significant reductions in the median number of outpatient visits, operated cases, on-call hours, emergency visits, and research work, so, 48.2% of respondents felt that the training resources were insufficient. The majority (81.3%) of respondents reported that their hospitals were included in the management of COVID-19, 66.5% felt their roles had been minimized; 41% were asked to assist in non-surgical medical practices, and 37.6% of respondents were included in COVID-19 management. Conclusions: There was a significant burnout among trainees. Almost all aspects of clinical and research activities were affected with a significant reduction in the volume of research, outpatient clinic visits, surgical procedures, on-call hours, and emergency cases hindering the training. Trial registration: The study was registered on clicaltrials.gov "NCT04433286" on 16/06/2020

Comparison of Central Corneal Thickness Measurements by Pentacam and Ultrasound Pachymetry in Normal Myopic Patients

Introduction: Precise measurement of corneal thickness is of crucial importance in corneal refractive procedures. The aim of this work is to compare the central corneal thickness measurements using Scheimpflug imaging (Pentacam) and contact US pachymetry in normal myopic patients. Methods: This retrospective cohort study was conducted on in 144 eyes of 72 normal myopic patients during 6 months. The study location was the Research Institute of Ophthalmology (Giza, Egypt), and Magrabi Eye Hospital (Dubai, United Arab Emirates). Central corneal thickness was measured with the two devices. Data were analyzed by descriptive statistics, independent-samples t-test, paired-samples t-test, Mann-Whitney U test and Pearson-Product Moment Correlation Coefficient. Results: The mean age was 25.3±5.6 years (range 18 to 38 years). The median age for our patients is 24 years. The average measurements of CCT were 526.8±35.3 and 529.1±37.9 for the Pentacam pachymetry and US pachymetry values, respectively. Mean difference between both measurements was 2.3±2.6μm which is statistically insignificant (p=0.08). Bland Altman Plot shows border line agreement of the two methods US pachymetry and Pentacam in detection of central corneal thickness. Conclusion: The results of this study showed no significant differences in CCT readings between the measurements obtained by Pentacam and US pachymetry in normal myopic patient