933 research outputs found

    Exact quantum master equation for a molecular aggregate coupled to a harmonic bath

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    We consider a molecular aggregate consisting of NN identical monomers. Each monomer comprises two electronic levels and a single harmonic mode. The monomers interact with each other via dipole-dipole forces. The monomer vibrational modes are bilinearly coupled to a bath of harmonic oscillators. This is a prototypical model for the description of coherent exciton transport, from quantum dots to photosynthetic antennae. We derive an exact quantum master equation for such systems. Computationally, the master equation may be useful for the testing of various approximations employed in theories of quantum transport. Physically, it offers a plausible explanation of the origins of long-lived coherent optical responses of molecular aggregates in dissipative environments

    Extrapolation of the principles of the quality management for the organization of the system of housing and communal services

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    Π’ ΡΡ‚Π°Ρ‚ΡŒΠ΅ рассмотрСна Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎΡΡ‚ΡŒ примСнСния ΠΏΡ€ΠΈΠ½Ρ†ΠΈΠΏΠΎΠ² ΠΌΠ΅Π½Π΅Π΄ΠΆΠΌΠ΅Π½Ρ‚Π° качСства Π² сфСрС ΠΆΠΈΠ»ΠΈΡ‰Π½ΠΎ-ΠΊΠΎΠΌΠΌΡƒΠ½Π°Π»ΡŒΠ½ΠΎΠ³ΠΎ хозяйства. Π˜Ρ… Π²Π½Π΅Π΄Ρ€Π΅Π½ΠΈΠ΅ Π² ΡƒΠΏΡ€Π°Π²Π»ΡΡŽΡ‰ΠΈΡ… компаниях являСтся прСдпосылкой для Ρ€Π°Π·Ρ€Π°Π±ΠΎΡ‚ΠΊΠΈ систСмы ΠΌΠ΅Π½Π΅Π΄ΠΆΠΌΠ΅Π½Ρ‚Π° качСства, Ρ‡Ρ‚ΠΎ ΠΏΠΎΠ·Π²ΠΎΠ»ΠΈΡ‚ ΡƒΠΏΡ€Π°Π²Π»ΡΡŽΡ‰ΠΈΠΌ компаниям Π²Ρ‹ΠΉΡ‚ΠΈ Π½Π° ΡƒΡ€ΠΎΠ²Π΅Π½ΡŒ управлСния качСством услуг для ΠΏΠΎΡ‚Ρ€Π΅Π±ΠΈΡ‚Π΅Π»Π΅ΠΉ, ΡΠΎΠΎΡ‚Π²Π΅Ρ‚ΡΡ‚Π²ΡƒΡŽΡ‰ΠΈΠΉ ΠΌΠ΅ΠΆΠ΄ΡƒΠ½Π°Ρ€ΠΎΠ΄Π½Ρ‹ΠΌ стандартамIn the article the possibility of application of quality management principles in the sphere of hous-ing and communal services. Their implementation in management companies is a prerequisite for the development of a quality management system that will allow management companies to reach the level of quality management services for consumers that meets international standard

    Personnel management company housing as a key element of the quality management system and its preparation for the implementation of QMS

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    The introduction of new approaches to management, for example, the introduction of quality management system contributes to the resolution of many problems of modern enterprises, which does not bypass the sphere of housing and communal services. Any development and change takes place through training, which helps a person to adapt their behavior to changing external conditions. Therefore, the issue of staff training in the implementation of changes should be given increased attention. In this regard, the organization plans to develop a consulting system that will Β«on its ownΒ» to prepare employees for the implementation of QMSΠ’Π½Π΅Π΄Ρ€Π΅Π½ΠΈΠ΅ Π½ΠΎΠ²Ρ‹Ρ… ΠΏΠΎΠ΄Ρ…ΠΎΠ΄ΠΎΠ² ΠΊ ΠΎΡ€Π³Π°Π½ΠΈΠ·Π°Ρ†ΠΈΠΈ управлСния, Π½Π°ΠΏΡ€ΠΈΠΌΠ΅Ρ€, Π²Π½Π΅Π΄Ρ€Π΅Π½ΠΈΠ΅ систСмы ΠΌΠ΅Π½Π΅Π΄ΠΆΠΌΠ΅Π½Ρ‚Π° качСства способствуСт Ρ€Π°Π·Ρ€Π΅ΡˆΠ΅Π½ΠΈΡŽ ΠΌΠ½ΠΎΠ³ΠΈΡ… ΠΏΡ€ΠΎΠ±Π»Π΅ΠΌ соврСмСнных прСдприятий, Ρ‡Ρ‚ΠΎ Π½Π΅ ΠΎΠ±Ρ…ΠΎΠ΄ΠΈΡ‚ стороной ΠΈ сфСру ΠΆΠΈΠ»ΠΈΡ‰Π½ΠΎ-ΠΊΠΎΠΌΠΌΡƒΠ½Π°Π»ΡŒΠ½ΠΎΠ³ΠΎ хозяйства. Π›ΡŽΠ±ΠΎΠ΅ Ρ€Π°Π·Π²ΠΈΡ‚ΠΈΠ΅ ΠΈ ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ происходит Ρ‡Π΅Ρ€Π΅Π· ΠΎΠ±ΡƒΡ‡Π΅Π½ΠΈΠ΅, ΠΊΠΎΡ‚ΠΎΡ€ΠΎΠ΅ ΠΏΠΎΠΌΠΎΠ³Π°Π΅Ρ‚ Ρ‡Π΅Π»ΠΎΠ²Π΅ΠΊΡƒ Π°Π΄Π°ΠΏΡ‚ΠΈΡ€ΠΎΠ²Π°Ρ‚ΡŒ своС ΠΏΠΎΠ²Π΅Π΄Π΅Π½ΠΈΠ΅ ΠΊ ΠΈΠ·ΠΌΠ΅Π½ΡΡŽΡ‰ΠΈΠΌΡΡ внСшним условиям. ΠŸΠΎΡΡ‚ΠΎΠΌΡƒ вопросу обучСния пСрсонала Π² Ρ…ΠΎΠ΄Π΅ внСдрСния ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΠΉ слСдуСт ΡƒΠ΄Π΅Π»ΡΡ‚ΡŒ ΠΏΠΎΠ²Ρ‹ΡˆΠ΅Π½Π½ΠΎΠ΅ Π²Π½ΠΈΠΌΠ°Π½ΠΈΠ΅. Π’ связи с этим организация ΠΏΠ»Π°Π½ΠΈΡ€ΡƒΠ΅Ρ‚ Ρ€Π°Π·Ρ€Π°Π±ΠΎΡ‚Π°Ρ‚ΡŒ систСму ΠΊΠΎΠ½ΡΡƒΠ»ΡŒΡ‚ΠΈΡ€ΠΎΠ²Π°Π½ΠΈΡ, которая ΠΏΠΎΠ·Π²ΠΎΠ»ΠΈΡ‚ «своими силами» ΠΏΠΎΠ΄Π³ΠΎΡ‚ΠΎΠ²ΠΈΡ‚ΡŒ сотрудников ΠΊ Π²Π½Π΅Π΄Ρ€Π΅Π½ΠΈΡŽ БМ

    Azimuthal modulation of the event rate of cosmic ray extensive air showers by the geomagnetic field

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    The Earth's magnetic field effect on the azimuthal distribution of extensive air showers (EAS) of cosmic rays has been evaluated using a bulk of the Yakutsk array data. The uniform azimuthal distribution of the EAS event rate is rejected at the significance level 10^(-14). Amplitude of the first harmonics of observed distribution depends on zenith angle as A1=0.2*sin^2(theta) and is almost independent of the primary energy; the phase coincides with the magnetic meridian. Basing upon the value of measured effect, the correction factor has been derived for the particle density depending on a geomagnetic parameter of a shower.Comment: 4 pages, 3 figures in ps file

    ГосударствСнная ΠΏΠΎΠ΄Π΄Π΅Ρ€ΠΆΠΊΠ° инвСстиционных ΠΏΡ€ΠΎΠ΅ΠΊΡ‚ΠΎΠ² Π² Ρ€Π°ΠΌΠΊΠ°Ρ… соглашСния ΠΎ Π·Π°Ρ‰ΠΈΡ‚Π΅ ΠΈ ΠΏΠΎΠΎΡ‰Ρ€Π΅Π½ΠΈΠΈ ΠΊΠ°ΠΏΠΈΡ‚Π°Π»ΠΎΠ²Π»ΠΎΠΆΠ΅Π½ΠΈΠΉ: мСтодологичСскоС обоснованиС

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    The subject of research is economic interactions related to the implementation of an investment project within the framework of an agreement on the protection and promotion of investments (hereinafter referred to as the APCI).Purpose: methodological substantiation of the expediency of providing state support measures to ensure the minimum profitability of an investment project implemented within the framework of the APCI.Objectives: to propose an indicator that reflects the minimum profitability of an investment project, the mechanism for its usage to determine state support measures, additional state support measures in cases where they are not sufficiently established in the legislation.Methods: analysis of approaches to determining the discount rate; statistical (observation, grouping, method of indicators) for calculating industry-specific ROIC values; content analysis to select state support measures.Results: it is proposed to use the ROIC indicator as the minimum profitability of a commercial investment project. The indicator was calculated according to the data of all organizations that are not subjects of medium and small enterprises operating in the period 2012–2021. The sample included 133 organizations that make up eight subclasses of Russian classifier of types of economic activity (pulp and paper production; production of fertilizers and nitrogen compounds; production of pesticides, etc.; production of paints, varnishes, etc.; production of pharmaceutical substances; production of medicines; activities in the field of telecommunications; development of computer software). Based on the data from 1011 observations, the median value of ROIC for each subclass was calculated, the reliability of which is confirmed by the approved minimum rates of return on invested capital for calculating the tariffs of regulated organizations. A mechanism is proposed for using ROIC to determine state support measures within the framework of the APCI, including: determining the median value of ROIC for foreign economic activity, calculating ROIC for an investment project, and determining state support measures by their ratio. As additional measures of state support within the framework of the APCI, it is proposed to establish tax preferences (lower tax rates, tax benefits, tax deductions), as well as accelerated depreciation of fixed assets. The proposed developments create a methodological basis for substantiating the provision of various state support measures within the framework of the APCI.ΠŸΡ€Π΅Π΄ΠΌΠ΅Ρ‚ исслСдования β€”Β  экономичСскиС ΠΎΡ‚Π½ΠΎΡˆΠ΅Π½ΠΈΡ, связанныС с осущСствлСниСм инвСстиционного ΠΏΡ€ΠΎΠ΅ΠΊΡ‚Π°, Ρ€Π΅Π°Π»ΠΈΠ·ΡƒΠ΅ΠΌΠΎΠ³ΠΎ Π² Ρ€Π°ΠΌΠΊΠ°Ρ… соглашСния ΠΎ Π·Π°Ρ‰ΠΈΡ‚Π΅ ΠΈ ΠΏΠΎΠΎΡ‰Ρ€Π΅Π½ΠΈΠΈ ΠΊΠ°ΠΏΠΈΡ‚Π°Π»ΠΎΠ²Π»ΠΎΠΆΠ΅Π½ΠΈΠΉ (Π΄Π°Π»Π΅Π΅ β€”Β  Π‘Π—ΠŸΠš).ЦСль: мСтодологичСскоС обоснованиС цСлСсообразности прСдоставлСния ΠΌΠ΅Ρ€ господдСрТки для обСспСчСния минимальной доходности инвСстиционного ΠΏΡ€ΠΎΠ΅ΠΊΡ‚Π°, Ρ€Π΅Π°Π»ΠΈΠ·ΡƒΠ΅ΠΌΠΎΠ³ΠΎ Π² Ρ€Π°ΠΌΠΊΠ°Ρ… Π‘Π—ΠŸΠš.Π—Π°Π΄Π°Ρ‡ΠΈ: ΠΏΡ€Π΅Π΄Π»ΠΎΠΆΠΈΡ‚ΡŒ ΠΏΠΎΠΊΠ°Π·Π°Ρ‚Π΅Π»ΡŒ, ΠΎΡ‚Ρ€Π°ΠΆΠ°ΡŽΡ‰ΠΈΠΉ ΠΌΠΈΠ½ΠΈΠΌΠ°Π»ΡŒΠ½ΡƒΡŽ Π΄ΠΎΡ…ΠΎΠ΄Π½ΠΎΡΡ‚ΡŒ инвСстиционного ΠΏΡ€ΠΎΠ΅ΠΊΡ‚Π°, ΠΌΠ΅Ρ…Π°Π½ΠΈΠ·ΠΌ Π΅Π³ΠΎ использования для опрСдСлСния ΠΌΠ΅Ρ€ господдСрТки, Π΄ΠΎΠΏΠΎΠ»Π½ΠΈΡ‚Π΅Π»ΡŒΠ½Ρ‹Π΅ ΠΌΠ΅Ρ€Ρ‹ господдСрТки Π² случаС нСдостаточно установлСнных Π² Π·Π°ΠΊΠΎΠ½ΠΎΠ΄Π°Ρ‚Π΅Π»ΡŒΡΡ‚Π²Π΅.ΠœΠ΅Ρ‚ΠΎΠ΄Ρ‹: Π°Π½Π°Π»ΠΈΠ· ΠΏΠΎΠ΄Ρ…ΠΎΠ΄ΠΎΠ² ΠΊ ΠΎΠΏΡ€Π΅Π΄Π΅Π»Π΅Π½ΠΈΡŽ ставки дисконтирования; статистичСскиС (наблюдСниС, Π³Ρ€ΡƒΠΏΠΏΠΈΡ€ΠΎΠ²ΠΊΠ°, ΠΌΠ΅Ρ‚ΠΎΠ΄ ΠΏΠΎΠΊΠ°Π·Π°Ρ‚Π΅Π»Π΅ΠΉ) для расчСта отраслСвых Π·Π½Π°Ρ‡Π΅Π½ΠΈΠΉ ROIC; ΠΊΠΎΠ½Ρ‚Π΅Π½Ρ‚-Π°Π½Π°Π»ΠΈΠ· для Π²Ρ‹Π±ΠΎΡ€Π° ΠΌΠ΅Ρ€ господдСрТки.Π Π΅Π·ΡƒΠ»ΡŒΡ‚Π°Ρ‚Ρ‹: Π² качСствС минимальной доходности коммСрчСского инвСстиционного ΠΏΡ€ΠΎΠ΅ΠΊΡ‚Π° ΠΏΡ€Π΅Π΄Π»ΠΎΠΆΠ΅Π½ΠΎ ΠΈΡΠΏΠΎΠ»ΡŒΠ·ΠΎΠ²Π°Ρ‚ΡŒ ΠΏΠΎΠΊΠ°Π·Π°Ρ‚Π΅Π»ΡŒ ROIC. ΠŸΡ€ΠΎΠ²Π΅Π΄Π΅Π½ расчСт показатСля ΠΏΠΎ Π΄Π°Π½Π½Ρ‹ΠΌ всСх ΠΎΡ€Π³Π°Π½ΠΈΠ·Π°Ρ†ΠΈΠΉ, Π½Π΅ ΡΠ²Π»ΡΡŽΡ‰ΠΈΡ…ΡΡ ΡΡƒΠ±ΡŠΠ΅ΠΊΡ‚Π°ΠΌΠΈ срСдних ΠΈ ΠΌΠ°Π»Ρ‹Ρ… прСдприятий, Ρ„ΡƒΠ½ΠΊΡ†ΠΈΠΎΠ½ΠΈΡ€ΡƒΡŽΡ‰ΠΈΡ… Π² ΠΏΠ΅Ρ€ΠΈΠΎΠ΄ 2012–2021 Π³Π³. Π’ Π²Ρ‹Π±ΠΎΡ€ΠΊΡƒ вошли 133 ΠΎΡ€Π³Π°Π½ΠΈΠ·Π°Ρ†ΠΈΠΈ, ΡΠΎΡΡ‚Π°Π²Π»ΡΡŽΡ‰ΠΈΠ΅ восСмь подклассов ΠžΠšΠ’Π­Π” (производство Ρ†Π΅Π»Π»ΡŽΠ»ΠΎΠ·Ρ‹ ΠΈ Π±ΡƒΠΌΠ°Π³ΠΈ; производство ΡƒΠ΄ΠΎΠ±Ρ€Π΅Π½ΠΈΠΉ ΠΈ Π°Π·ΠΎΡ‚Π½Ρ‹Ρ… соСдинСний; производство пСстицидов ΠΈ Π΄Ρ€.; производство красок, Π»Π°ΠΊΠΎΠ² ΠΈ Π΄Ρ€.; производство фармацСвтичСских субстанций; производство лСкарствСнных ΠΏΡ€Π΅ΠΏΠ°Ρ€Π°Ρ‚ΠΎΠ²; Π΄Π΅ΡΡ‚Π΅Π»ΡŒΠ½ΠΎΡΡ‚ΡŒ Π² сфСрС Ρ‚Π΅Π»Π΅ΠΊΠΎΠΌΠΌΡƒΠ½ΠΈΠΊΠ°Ρ†ΠΈΠΉ; Ρ€Π°Π·Ρ€Π°Π±ΠΎΡ‚ΠΊΠ° ΠΊΠΎΠΌΠΏΡŒΡŽΡ‚Π΅Ρ€Π½ΠΎΠ³ΠΎ ΠΏΡ€ΠΎΠ³Ρ€Π°ΠΌΠΌΠ½ΠΎΠ³ΠΎ обСспСчСния). По Π΄Π°Π½Π½Ρ‹ΠΌ 1011 наблюдСний рассчитано ΠΌΠ΅Π΄ΠΈΠ°Π½Π½ΠΎΠ΅ Π·Π½Π°Ρ‡Π΅Π½ΠΈΠ΅ ROIC для ΠΊΠ°ΠΆΠ΄ΠΎΠ³ΠΎ подкласса, Π΄ΠΎΡΡ‚ΠΎΠ²Π΅Ρ€Π½ΠΎΡΡ‚ΡŒ ΠΊΠΎΡ‚ΠΎΡ€ΠΎΠ³ΠΎ подтвСрТдаСтся ΡƒΡ‚Π²Π΅Ρ€ΠΆΠ΄Π΅Π½Π½Ρ‹ΠΌΠΈ ΠΌΠΈΠ½ΠΈΠΌΠ°Π»ΡŒΠ½Ρ‹ΠΌΠΈ Π½ΠΎΡ€ΠΌΠ°ΠΌΠΈ доходности инвСстированного ΠΊΠ°ΠΏΠΈΡ‚Π°Π»Π° для расчСта Ρ‚Π°Ρ€ΠΈΡ„ΠΎΠ² Ρ€Π΅Π³ΡƒΠ»ΠΈΡ€ΡƒΠ΅ΠΌΡ‹Ρ… ΠΎΡ€Π³Π°Π½ΠΈΠ·Π°Ρ†ΠΈΠΉ. ΠŸΡ€Π΅Π΄Π»ΠΎΠΆΠ΅Π½ ΠΌΠ΅Ρ…Π°Π½ΠΈΠ·ΠΌ использования ROIC для опрСдСлСния ΠΌΠ΅Ρ€ господдСрТки Π² Ρ€Π°ΠΌΠΊΠ°Ρ… Π‘Π—ΠŸΠš, Π²ΠΊΠ»ΡŽΡ‡Π°ΡŽΡ‰ΠΈΠΉ: ΠΎΠΏΡ€Π΅Π΄Π΅Π»Π΅Π½ΠΈΠ΅ ΠΌΠ΅Π΄ΠΈΠ°Π½Π½ΠΎΠ³ΠΎ значСния ROIC ΠΏΠΎ Π’Π­Π”, расчСт ROIC ΠΏΠΎ инвСстиционному ΠΏΡ€ΠΎΠ΅ΠΊΡ‚Ρƒ, ΠΎΠΏΡ€Π΅Π΄Π΅Π»Π΅Π½ΠΈΠ΅ ΠΌΠ΅Ρ€ господдСрТки ΠΏΠΎ ΠΈΡ… ΡΠΎΠΎΡ‚Π½ΠΎΡˆΠ΅Π½ΠΈΡŽ. Π’ качСствС Π΄ΠΎΠΏΠΎΠ»Π½ΠΈΡ‚Π΅Π»ΡŒΠ½Ρ‹Ρ… ΠΌΠ΅Ρ€ господдСрТки Π² Ρ€Π°ΠΌΠΊΠ°Ρ… Π‘Π—ΠŸΠš ΠΏΡ€Π΅Π΄Π»ΠΎΠΆΠ΅Π½ΠΎ ΡƒΡΡ‚Π°Π½ΠΎΠ²ΠΈΡ‚ΡŒ Π½Π°Π»ΠΎΠ³ΠΎΠ²Ρ‹Π΅ ΠΏΡ€Π΅Ρ„Π΅Ρ€Π΅Π½Ρ†ΠΈΠΈ (ΠΏΠΎΠ½ΠΈΠΆΠ΅Π½Π½Ρ‹Π΅ Π½Π°Π»ΠΎΠ³ΠΎΠ²Ρ‹Π΅ ставки, Π½Π°Π»ΠΎΠ³ΠΎΠ²Ρ‹Π΅ Π»ΡŒΠ³ΠΎΡ‚Ρ‹, Π½Π°Π»ΠΎΠ³ΠΎΠ²Ρ‹Π΅ Π²Ρ‹Ρ‡Π΅Ρ‚Ρ‹), Π° Ρ‚Π°ΠΊΠΆΠ΅ ΠΈΡΠΏΠΎΠ»ΡŒΠ·ΠΎΠ²Π°Ρ‚ΡŒ ΡƒΡΠΊΠΎΡ€Π΅Π½Π½ΡƒΡŽ Π°ΠΌΠΎΡ€Ρ‚ΠΈΠ·Π°Ρ†ΠΈΡŽ основных срСдств. ΠŸΡ€Π΅Π΄Π»ΠΎΠΆΠ΅Π½Π½Ρ‹Π΅ Ρ€Π°Π·Ρ€Π°Π±ΠΎΡ‚ΠΊΠΈ ΡΠΎΠ·Π΄Π°ΡŽΡ‚ ΠΌΠ΅Ρ‚ΠΎΠ΄ΠΎΠ»ΠΎΠ³ΠΈΡ‡Π΅ΡΠΊΡƒΡŽ основу обоснования прСдоставлСния Ρ€Π°Π·Π»ΠΈΡ‡Π½Ρ‹Ρ… ΠΌΠ΅Ρ€ господдСрТки Π² Ρ€Π°ΠΌΠΊΠ°Ρ… Π‘Π—ΠŸΠš

    Spatial beam self-cleaning and supercontinuum generation with Yb-doped multimode graded-index fiber taper based on accelerating self-imaging and dissipative landscape

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    We experimentally demonstrate spatial beam self-cleaning and supercontinuum generation in a tapered Ytterbium-doped multimode optical fiber with parabolic core refractive index profile when 1064β€…nm pulsed beams propagate from wider (122β€…Β΅m) into smaller (37β€…Β΅m) diameter. In the passive mode, increasing the input beam peak power above 20β€…kW leads to a bell-shaped output beam profile. In the active configuration, gain from the pump laser diode permits to combine beam self-cleaning with supercontinuum generation between 520-2600β€…nm. By taper cut-back, we observed that the dissipative landscape, i.e., a non-monotonic variation of the average beam power along the MMF, leads to modal transitions of self-cleaned beams along the taper length

    Dependence of the Energy Spectrum of UHE Cosmic Rays on the Latitude of an Extensive Air Shower Array

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    Several energy spectra of cosmic rays with energies E_0 \geq 10^17 eV measured at the Yakutsk EAS, AGASA, Haverah Park, HiRes, Auger, and SUGAR arrays are considered. It is shown that the fairly good mutual agreement of the spectrum shapes can be achieved if the energy of each spectrum is multiplied by a factor K specific for each spectrum. These factors exhibit a pronounced dependence on the latitude of the above-mentioned arrays.Comment: 4 pages, 4 figure

    The 1986?1989 ENSO cycle in a chemical climate model

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    International audienceA pronounced ENSO cycle occurred from 1986 to 1989, accompanied by distinct dynamical and chemical anomalies in the global troposphere and stratosphere. Reproducing these effects with current climate models not only provides a model test but also contributes to our still limited understanding of ENSO's effect on stratosphere-troposphere coupling. We performed several sets of ensemble simulations with a chemical climate model (SOCOL) forced with global sea surface temperatures. Results were compared with observations and with large-ensemble simulations performed with an atmospheric general circulation model (MRF9). We focus our analysis on the extratropical stratosphere and its coupling with the troposphere. In this context, the circulation over the North Atlantic sector is particularly important. Observed differences between the El NiΓ±o winter 1987 and the La NiΓ±a winter 1989 include a negative North Atlantic Oscillation index with corresponding changes in temperature and precipitation patterns, a weak polar vortex, a warm Arctic middle stratosphere, negative and positive total ozone anomalies in the tropics and at middle to high latitudes, respectively, as well as anomalous upward and poleward Eliassen-Palm (EP) flux in the midlatitude lower stratosphere. Most of the tropospheric features are well reproduced in the ensemble means in both models, though the amplitudes are underestimated. In the stratosphere, the SOCOL simulations compare well with observations with respect to zonal wind, temperature, EP flux, and ozone, but magnitudes are underestimated in the middle stratosphere. The polar vortex strength is well reproduced, but within-ensemble variability is too large for obtaining a significant signal in Arctic temperature and ozone. With respect to the mechanisms relating ENSO to stratospheric circulation, the results suggest that both, upward and poleward components of anomalous EP flux are important for obtaining the stratospheric signal and that an increase in strength of the Brewer-Dobson circulation is part of that signal

    Stem cells application for the treatment of traumatic brain injury

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    Traumatic brain injury (TBI) is a global medical and socio-economic problem. Traumatic injuries of the skull and brain make up 30-40β€Š% of all traumas and are the first in terms of mortality and disability among people of working age. High expectations for the treatment of TBI and its consequences are due to the use of stem cell (SCs) therapy. The present review examines the pathogenetic prerequisites for SCs application in TBI effects treatment: generalizes information about the primary and secondary changes in nerve tissue after TBI (cellular, tissue, organ, systemic level) and functional neurological disorders (physical, motor, cognitive, behavioral symptoms); emphasizes the impossibility of restoring neurological functions without restoring brain structures and functions. The paper proposes the main directions of application of SCs for the TBI effects treatment - stimulation of endogenous SCs, transplantation of exogenous SCs and a combination of these approaches. The sources and types of SCs considered for the restoration of the damaged organ and its functional parameters are characterized in detail: embryonic (ESCs), neurogenic (NSC/NPCs), stromal (SCs of bone marrow, adipose tissue, including mesenchymal (MSCs), hematopoietic (HSCs), umbilical cord blood SCs, induced pluripotent SCs (iPSCs). The results of preclinical studies of the different SCs types used in animals with TBI experimental models are summarized. The actual information regarding clinical trials on the safety and efficacy of the SCs application in the TBI effects treatment in the directions of endogenous SCs stimulation (drug administration, physical methods) and exogenous SCs transplantation (autologous SCs (bone marrow, adipose tissue) and allogeneic SCs (MSCs, bone marrow SCs, umbilical cord blood SCs) is analyzed. The gradual accumulation of clinical trial results will allow future meta-analytic studies and the development of certified standardized protocols for the treatment of TBI consequences using the benefits of SCs
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