The Innovative FlexPlan Grid-Planning Methodology: How Storage and Flexible Resources Could Help in De-Bottlenecking the European System

The FlexPlan Horizon2020 project aims at establishing a new grid-planning methodology which considers the opportunity to introduce new storage and flexibility resources in electricity transmission and distribution grids as an alternative to building new grid elements, in accordance with the intentions of the Clean Energy for all Europeans regulatory package of the European Commission. FlexPlan creates a new innovative grid-planning tool whose ambition is to go beyond the state of the art of planning methodologies by including the following innovative features: assessment of the best planning strategy by analysing in one shot a high number of candidate expansion options provided by a pre-processor tool, simultaneous mid- and long-term planning assessment over three grid years (2030, 2040, 2050), incorporation of a full range of cost–benefit analysis criteria into the target function, integrated transmission distribution planning, embedded environmental analysis (air quality, carbon footprint, landscape constraints), probabilistic contingency methodologies in replacement of the traditional N-1 criterion, application of numerical decomposition techniques to reduce calculation efforts and analysis of variability of yearly renewable energy sources (RES) and load time series through a Monte Carlo process. Six regional cases covering nearly the whole European continent are developed in order to cast a view on grid planning in Europe till 2050. FlexPlan will end up formulating guidelines for regulators and planning offices of system operators by indicating to what extent system flexibility can contribute to reducing overall system costs (operational + investment) yet maintaining current system security levels and which regulatory provisions could foster such process. This paper provides a complete description of the modelling features of the planning tool and pre-processor and provides the first results of their application in small-scale scenariosThe research leading to these results/this publication received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement no. 86381

mTOR inhibition via displacement of phosphatidic acid induces enhanced cytotoxicity specifically in cancer cells

International audienceThe mTOR is a central regulator of cell growth and is highly activated in cancer cells to allow rapid tumor growth. The use of mTOR inhibitors as anticancer therapy has been approved for some types of tumors, albeit with modest results. We recently reported the synthesis of ICSN3250, a halitulin analogue with enhanced cytotoxicity. We report here that ICSN3250 is a specific mTOR inhibitor that operates through a mechanism distinct from those described for previous mTOR inhibitors. ICSN3250 competed with and displaced phosphatidic acid from the FRB domain in mTOR, thus preventing mTOR activation and leading to cytotoxicity. Docking and molecular dynamics simulations evidenced not only the high conformational plasticity of the FRB domain, but also the specific interactions of both ICSN3250 and phosphatidic acid with the FRB domain in mTOR. Furthermore, ICSN3250 toxicity was shown to act specifically in cancer cells, as noncancer cells showed up to 100-fold less sensitivity to ICSN3250, in contrast to other mTOR inhibitors that did not show selectivity. Thus, our results define ICSN3250 as a new class of mTOR inhibitors that specifically targets cancer cells.Significance: ICSN3250 defines a new class of mTORC1 inhibitors that displaces phosphatidic acid at the FRB domain of mTOR, inducing cell death specifically in cancer cells but not in noncancer cells

Study of dijet events with large rapidity separation in proton-proton collisions at s \sqrt{s} = 2.76 TeV

International audienceThe cross sections for inclusive and Mueller-Navelet dijet production are measured as a function of the rapidity separation between the jets in proton-proton collisions at $\sqrt{s}$ = 2.76 TeV for jets with transverse momentum p$_{T}$> 35 GeV and rapidity |y| 20 GeV is introduced to improve the sensitivity to the effects of the Balitsky-Fadin-Kuraev-Lipatov (BFKL) evolution. The measurement is compared with the predictions of various Monte Carlo models based on leading-order and next-to-leading-order calculations including the Dokshitzer-Gribov-Lipatov-Altarelli-Parisi leading-logarithm (LL) parton shower as well as the LL BFKL resummation.[graphic not available: see fulltext