20 research outputs found
Simulation Study of Photon-to-Digital Converter (PDC) Timing Specifications for LoLX Experiment
The Light only Liquid Xenon (LoLX) experiment is a prototype detector aimed
to study liquid xenon (LXe) light properties and various photodetection
technologies. LoLX is also aimed to quantify LXe's time resolution as a
potential scintillator for 10~ps time-of-flight (TOF) PET. Another key goal of
LoLX is to perform a time-based separation of Cerenkov and scintillation
photons for new background rejection methods in LXe experiments. To achieve
this separation, LoLX is set to be equipped with photon-to-digital converters
(PDCs), a photosensor type that provides a timestamp for each observed photon.
To guide the PDC design, we explore requirements for time-based Cerenkov
separation. We use a PDC simulator, whose input is the light information from
the Geant4-based LoLX simulation model, and evaluate the separation quality
against time-to-digital converter (TDC) parameters. Simulation results with TDC
parameters offer possible configurations supporting a good separation. Compared
with the current filter-based approach, simulations show Cerenkov separation
level increases from 54% to 71% when using PDC and time-based separation. With
the current photon time profile of LoLX simulation, the results also show 71%
separation is achievable with just 4 TDCs per PDC. These simulation results
will lead to a specification guide for the PDC as well as expected results to
compare against future PDC-based experimental measurements. In the longer term,
the overall LoLX results will assist large LXe-based experiments and motivate
the assembly of a LXe-based TOF-PET demonstrator system.Comment: 5 pages, 7 figure
Central Iliac Arteriovenous Anastomosis for Hypertension: Targeting Mechanical Aspects of the Circulation
Strain typing of Mycobacterium bovis isolates
Department of Agriculture, Food and the MarineTeagascDeposited by bulk impor
Microindentation of fresh soft biological tissue: A rapid tissue sectioning and mounting protocol
Microindentation of fresh biological tissues is necessary for the creation of 3D biomimetic models that accurately represent the native extracellular matrix microenvironment. However, tissue must first be precisely sectioned into slices. Challenges exist in the preparation of fresh tissue slices, as they can tear easily and must be processed rapidly in order to mitigate tissue degradation. In this study, we propose an optimised mounting condition for microindentation and demonstrate that embedding tissue in a mixture of 2.5% agarose and 1.5% gelatin is the most favourable method of tissue slice mounting for microindentation. This protocol allows for rapid processing of fresh biological tissue and is applicable to a variety of tissue types.ISSN:1932-620
Process flow on rapid sectioning and mounting protocol.
Process flow on rapid sectioning and mounting protocol.</p
Raw and processed mechanical data for human femoral vein and porcine colon, including descriptive statistics.
Raw and processed mechanical data for human femoral vein and porcine colon, including descriptive statistics.</p
Step-by-step protocol, also available on protocols.io.
Step-by-step protocol, also available on protocols.io.</p