265 research outputs found
Evidence for a Positive Cosmological Constant from Flows of Galaxies and Distant Supernovae
Recent observations of high-redshift supernovae seem to suggest that the
global geometry of the Universe may be affected by a `cosmological constant',
which acts to accelerate the expansion rate with time. But these data by
themselves still permit an open universe of low mass density and no
cosmological constant. Here we derive an independent constraint on the lower
bound to the mass density, based on deviations of galaxy velocities from a
smooth universal expansion. This constraint rules out a low-density open
universe with a vanishing cosmological constant, and together the two favour a
nearly flat universe in which the contributions from mass density and the
cosmological constant are comparable. This type of universe, however, seems to
require a degree of fine tuning of the initial conditions that is in apparent
conflict with `common wisdom'.Comment: 8 pages, 1 figure. Slightly revised version. Letter to Natur
Constructing Dirac linear fermions in terms of non-linear Heisenberg spinors
We show that the massive (or massless) neutrinos can be described as special
states of Heisenberg nonlinear spinors. As a by-product of this decomposition a
particularly attractive consequence appears: the possibility of relating the
existence of only three species of mass-less neutrinos to such internal
non-linear structure. At the same time it allows the possibility that neutrino
oscillation can occurs even for massless neutrinos
Analyzing redshift surveys to measure the power spectrum on large scales
Upcoming large redshift surveys potentially allow precision measurements of
the galaxy power spectrum. To accurately measure P(k) on the largest scales,
comparable to the depth of the survey, it is crucial that finite volume effects
are accurately corrected for in the data analysis. Here we derive analytic
expressions for the one such effect that has not previously been worked out
exactly: that of the so-called integral constraint. We also show that for data
analysis methods based on counts in cells, multiple constraints can be included
via simple matrix operations, thereby rendering the results less sensitive to
galactic extinction and misestimates of the shape of the radial selection
function.Comment: Mostly superseded by astro-ph/9708020; from 5/5-97. 10 pages, with 1
figure included. More detailed treatment at
http://www.sns.ias.edu/~max/galpower.html (faster from the US), from
http://www.mpa-garching.mpg.de/~max/galpower.html (faster from Europe) or
from [email protected]
Measuring our universe from galaxy redshift surveys
Galaxy redshift surveys have achieved significant progress over the last
couple of decades. Those surveys tell us in the most straightforward way what
our local universe looks like. While the galaxy distribution traces the bright
side of the universe, detailed quantitative analyses of the data have even
revealed the dark side of the universe dominated by non-baryonic dark matter as
well as more mysterious dark energy (or Einstein's cosmological constant). We
describe several methodologies of using galaxy redshift surveys as cosmological
probes, and then summarize the recent results from the existing surveys.
Finally we present our views on the future of redshift surveys in the era of
Precision Cosmology.Comment: 82 pages, 31 figures, invited review article published in Living
Reviews in Relativity, http://www.livingreviews.org/lrr-2004-
Optimal duration of androgen deprivation therapy following radiation therapy in intermediate- or high-risk non-metastatic prostate cancer: A systematic review and meta-analysis
The Cosmological Constant
This is a review of the physics and cosmology of the cosmological constant.
Focusing on recent developments, I present a pedagogical overview of cosmology
in the presence of a cosmological constant, observational constraints on its
magnitude, and the physics of a small (and potentially nonzero) vacuum energy.Comment: 50 pages. Submitted to Living Reviews in Relativity
(http://www.livingreviews.org/), December 199
The 2dF galaxy redshift survey: near-infrared galaxy luminosity functions
We combine the Two Micron All Sky Survey (2MASS) Extended Source Catalogue and the 2dF Galaxy Redshift Survey to produce an infrared selected galaxy catalogue with 17 173 measured redshifts. We use this extensive data set to estimate the galaxy luminosity functions in the J- and KS-bands. The luminosity functions are fairly well fitted by Schechter functions with parameters MJ*−5 log h=−22.36±0.02, αJ=−0.93±0.04, ΦJ*=0.0104±0.0016 h3 Mpc3 in the J-band and MKS*−5 log h=−23.44±0.03, αKS=−0.96±0.05, ΦKS*=0.0108±0.0016 h3 Mpc3 in the KS-band (2MASS Kron magnitudes). These parameters are derived assuming a cosmological model with Ω0=0.3 and Λ0=0.7. With data sets of this size, systematic rather than random errors are the dominant source of uncertainty in the determination of the luminosity function. We carry out a careful investigation of possible systematic effects in our data. The surface brightness distribution of the sample shows no evidence that significant numbers of low surface brightness or compact galaxies are missed by the survey. We estimate the present-day distributions of bJ−KS and J−KS colours as a function of the absolute magnitude and use models of the galaxy stellar populations, constrained by the observed optical and infrared colours, to infer the galaxy stellar mass function. Integrated over all galaxy masses, this yields a total mass fraction in stars (in units of the critical mass density) of Ωstarsh =(1.6±0.24)×103 for a Kennicutt initial mass function (IMF) and Ωstarsh =(2.9±0.43)×103 for a Salpeter IMF. These values are consistent with those inferred from observational estimates of the total star formation history of the Universe provided that dust extinction corrections are modest
Extragalactic Results from the Infrared Space Observatory
More than a decade ago the IRAS satellite opened the realm of external
galaxies for studies in the 10 to 100 micron band and discovered emission from
tens of thousands of normal and active galaxies. With the 1995-1998 mission of
the Infrared Space Observatory the next major steps in extragalactic infrared
astronomy became possible: detailed imaging, spectroscopy and
spectro-photometry of many galaxies detected by IRAS, as well as deep surveys
in the mid- and far- IR. The spectroscopic data reveal a wealth of detail about
the nature of the energy source(s) and about the physical conditions in
galaxies. ISO's surveys for the first time explore the infrared emission of
distant, high-redshift galaxies. ISO's main theme in extragalactic astronomy is
the role of star formation in the activity and evolution of galaxies.Comment: 106 pages, including 17 figures. Ann.Rev.Astron.Astrophys. (in
press), a gzip'd pdf file (667kB) is also available at
http://www.mpe.mpg.de/www_ir/preprint/annrev2000.pdf.g
Validation of a 22-Gene Genomic Classifier in Patients With Recurrent Prostate Cancer An Ancillary Study of the NRG/RTOG 9601 Randomized Clinical Trial
IMPORTANCE: Decipher (Decipher Biosciences Inc) is a genomic classifier (GC) developed to estimate the risk of distant metastasis (DM) after radical prostatectomy (RP) in patients with prostate cancer.
OBJECTIVE:
To validate the GC in the context of a randomized phase 3 trial.
DESIGN, SETTING, AND PARTICIPANTS:
This ancillary study used RP specimens from the phase 3 placebo-controlled NRG/RTOG 9601 randomized clinical trial conducted from March 1998 to March 2003. The specimens were centrally reviewed, and RNA was extracted from the highest-grade tumor available in 2019 with a median follow-up of 13 years. Clinical-grade whole transcriptomes from samples passing quality control were assigned GC scores (scale, 0-1). A National Clinical Trials Network–approved prespecified statistical plan included the primary objective of validating the independent prognostic ability of GC for DM, with secondary end points of prostate cancer–specific mortality (PCSM) and overall survival (OS). Data were analyzed from September 2019 to December 2019.
INTERVENTIONS:
Salvage radiotherapy (sRT) with or without 2 years of bicalutamide.
MAIN OUTCOMES AND MEASURES:
The preplanned primary end point of this study was the independent association of the GC with the development of DM.
RESULTS:
In this ancillary study of specimens from a phase 3 randomized clinical trial, GC scores were generated from 486 of 760 randomized patients with a median follow-up of 13 years; samples from a total of 352 men (median [interquartile range] age, 64.5 (60-70) years; 314 White [89.2%] participants) passed microarray quality control and comprised the final cohort for analysis. On multivariable analysis, the GC (continuous variable, per 0.1 unit) was independently associated with DM (hazard ratio [HR], 1.17; 95% CI, 1.05-1.32; P = .006), PCSM (HR, 1.39; 95% CI, 1.20-1.63; P < .001), and OS (HR, 1.17; 95% CI, 1.06-1.29; P = .002) after adjusting for age, race/ethnicity, Gleason score, T stage, margin status, entry prostate-specific antigen, and treatment arm. Although the original planned analysis was not powered to detect a treatment effect interaction by GC score, the estimated absolute effect of bicalutamide on 12-year OS was less when comparing patients with lower vs higher GC scores (2.4% vs 8.9%), which was further demonstrated in men receiving early sRT at a prostate-specific antigen level lower than 0.7 ng/mL (−7.8% vs 4.6%).
CONCLUSIONS AND RELEVANCE:
This ancillary validation study of the Decipher GC in a randomized trial cohort demonstrated association of the GC with DM, PCSM, and OS independent of standard clinicopathologic variables. These results suggest that not all men with biochemically recurrent prostate cancer after surgery benefit equally from the addition of hormone therapy to sRT.
TRIAL REGISTRATION:
ClinicalTrials.gov identifier: NCT0000287
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