Penyuluhan Pembuatan Desain Packaging dan Digitalisasi Sosial Media kepada Pengrajin Manik-Manik di Lembang Angin-Angin

The work program for creating logo and packaging designs as well as digital technology is a service to the community engaged in the production business of bead craftsmen in Lembang Angin- Angin. These bead craftsmen have been established in Lembang Angin-angin for a long time, but their marketing methods are still very minimal and there is a lack of community skills related to UMKM. Therefore, these UMKM need to be given counseling about the importance of branding and the use of digital marketing so that their marketing system can be better so that they can expand the target market coverage and support marketing activities through business accounts on digital media. The method used is by providing counseling in the form of making a logo. , packaging and training on how to manage digital media for selling beads. This program has the potential to increase the sales appeal of beaded products, as well as serve as a symbol of product identity to make it easier for consumers to remember the product. This will support increased marketing activities and increase sales of the bead business

Stretching the IR theoretical spectrum on Irish neutrality: a critical social constructivist framework

In a 2006 International Political Science Review article, entitled "Choosing to Go It Alone: Irish Neutrality in Theoretical and Comparative Perspective," Neal G. Jesse argues that Irish neutrality is best understood through a neoliberal rather than a neorealist international relations theory framework. This article posits an alternative "critical social constructivist" framework for understanding Irish neutrality. The first part of the article considers the differences between neoliberalism and social constructivism and argues why critical social constructivism's emphasis on beliefs, identity, and the agency of the public in foreign policy are key factors explaining Irish neutrality today. Using public opinion data, the second part of the article tests whether national identity, independence, ethnocentrism, attitudes to Northern Ireland, and efficacy are factors driving public support for Irish neutrality. The results show that public attitudes to Irish neutrality are structured along the dimensions of independence and identity, indicating empirical support for a critical social constructivist framework of understanding of Irish neutrality

A likelihood ratio approach for utilizing case-control data in the clinical classification of rare sequence variants:Application to BRCA1 and BRCA2

A large number of variants identified through clinical genetic testing in disease susceptibility genes are of uncertain significance (VUS). Following the recommendations of the American College of Medical Genetics and Genomics (ACMG) and Association for Molecular Pathology (AMP), the frequency in case-control datasets (PS4 criterion) can inform their interpretation. We present a novel case-control likelihood ratio-based method that incorporates gene-specific age-related penetrance. We demonstrate the utility of this method in the analysis of simulated and real datasets. In the analysis of simulated data, the likelihood ratio method was more powerful compared to other methods. Likelihood ratios were calculated for a case-control dataset of BRCA1 and BRCA2 variants from the Breast Cancer Association Consortium (BCAC) and compared with logistic regression results. A larger number of variants reached evidence in favor of pathogenicity, and a substantial number of variants had evidence against pathogenicity findings that would not have been reached using other case-control analysis methods. Our novel method provides greater power to classify rare variants compared with classical case-control methods. As an initiative from the ENIGMA Analytical Working Group, we provide user-friendly scripts and preformatted Excel calculators for implementation of the method for rare variants in BRCA1, BRCA2, and other high-risk genes with known penetrance.</p

Profil Pengetahuan Masyarakat Tentang Narkotika, Psikotropika, Dan Zat Adiktif (Napza) Di Rt 041 Rw 011 Kelurahan Oebufu

Latar Belakang: Secara global kasus penyalahgunaan napza yang dilaporkan oleh United Nations Office on Drugs and Crime (UNODC) sebesar 269 juta orang pada tahun 2020 dimana jumlah tersebut 30% lebih banyak dari tahun sebelumnya. Di Indonesia kasus yang dilaporkan BNN pada tahun 2019 mengalami kenaikan sebesar 0,03% dimana kasus napza naik menjadi 1,80% dibandingkan dengan tahun 2017. Sedangkan, Kasus penyalahgunaan napza di NTT berdasarkan BNN pada tahun 2019 mencapai 36.000 jiwa dari total 5 juta penduduk di provinsi NTT. Tujuan Penelitian: untuk mengukur dan mendapatkan data terkait pengetahuan masyarakat RT 041 RW 011 Kelurahan Oebufu tentang pengetahuan umum napza, pengetahuan umum narkotika, pengetahuan umum psikotropika, dan pengetahuan umum zat adiktif. Metode: Penelitian dilakukan secara deskriptif dengan pengisian kuesioner oleh 75 responden sebagai sampel yang didapat dengan menggunakan teknik purposive sampling. Hasil: Pengetahuan masyarakat tentang pengetahuan umum napza cukup dengan responden sebanyak 48 (64%), pengetahuan tentang narkotika baik dengan responden sebanyak 66 (88%), pengetahuan tentang psikotropika baik dengan responden sebanyak 39 (52%), dan pengetahuan tentang zat adiktif baik dengan responden sebanyak 28 (37,33%). Simpulan: Pengetahuan masyarakat RT 041 RW 011 Kelurahan Oebufu tentang Napza dikategorikan cukup. Dengan rincian kategori cukup 45 responden (60%), baik 24 responden (32%), dan kurang 6 responden (8%)