Changemaker values within the Foundation Degree Learning and Teaching and the development of a Teaching Assistant Teachmeet Event

An article exploring the Changemaker values within the planning and delivery of the TeachMeet for teaching Assistants event

Linking geometry and algebra with GeoGebra

GeoGebra is a software package and is so named because it combines geometry and algebra as equal mathematical partners in its representations. At one level, GeoGebra can be as a dynamic geometry system like other, commercially available, software. But this is only part of the story. Another window (the algebra part of GeoGebra) provides an insight into the relationship between the geometric aspects of figures and their algebraic representations. Here each equation or set of coordinates can be edited in the algebra window and the figure instantly changes. What is more, an equation (or a function) can be typed into the space at the foot of the GeoGebra interface and the corresponding geometric representation will appear in the geometry window. Perhaps utilising GeoGebra could inspire a change from regular forms of enrichment/ extension activity to things that need high level thinking, and things that pupils may find themselves wanting to follow-up outside school lessons

Insights into the regulation of intrinsically disordered proteins in the human proteome by analyzing sequence and gene expression data

Background: Disordered proteins need to be expressed to carry out specified functions; however, their accumulation in the cell can potentially cause major problems through protein misfolding and aggregation. Gene expression levels, mRNA decay rates, microRNA (miRNA) targeting and ubiquitination have critical roles in the degradation and disposal of human proteins and transcripts. Here, we describe a study examining these features to gain insights into the regulation of disordered proteins. Results: In comparison with ordered proteins, disordered proteins have a greater proportion of predicted ubiquitination sites. The transcripts encoding disordered proteins also have higher proportions of predicted miRNA target sites and higher mRNA decay rates, both of which are indicative of the observed lower gene expression levels. The results suggest that the disordered proteins and their transcripts are present in the cell at low levels and/or for a short time before being targeted for disposal. Surprisingly, we find that for a significant proportion of highly disordered proteins, all four of these trends are reversed. Predicted estimates for miRNA targets, ubiquitination and mRNA decay rate are low in the highly disordered proteins that are constitutively and/or highly expressed. Conclusions: Mechanisms are in place to protect the cell from these potentially dangerous proteins. The evidence suggests that the enrichment of signals for miRNA targeting and ubiquitination may help prevent the accumulation of disordered proteins in the cell. Our data also provide evidence for a mechanism by which a significant proportion of highly disordered proteins (with high expression levels) can escape rapid degradation to allow them to successfully carry out their function

Can Carbon Labeling Be Development Friendly? Recommendations on How to Improve Emerging Schemes

Can Carbon Labeling Be Development Friendly? Recommendations on How to Improve Emerging SchemesCarbon accounting and labeling for products are new instruments of supply chain management that may affect developing country export opportunities. Most instruments in use today are private business management tools, although the underlying science and methodologies may spread to issues subject to public regulation. This note seeks to inform stakeholders involved in the design of carbon labeling schemes and in the making of carbon emission measurement methodologies about an overlooked issue: How can carbon labeling be made to be both development friendly and scientifically correct in its representation of developing-country agricultural sectors?trade, carbon, development, carbon accounting, carbon labeling, exports, imports, supply chain, regulations, trade barriers

Carbon Labelling and Low Income Country Exports: An Issues Paper

In response to growing concerns over climate change, consumers and firms in developed countries are considering their carbon footprint. Carbon labelling is being explored as a mechanism for greenhouse gas emission reduction primarily by private actors. This paper discusses the carbon accounting activities and carbon labelling schemes that are being developed to address these concerns with a view to their impact on small stakeholders, especially low income countries. This discussion centres on transportation, and the common presumption that products produced locally in the country of consumption will have an advantage in terms of carbon emissions, and on size. Exports from low income countries typically depend on long distance transportation and are produced by relatively small firms and tiny farms who will find it difficult to participate in complex carbon labelling schemes. However, the popular belief that trade by definition is problematic since it necessitates transportation, which is a major source of emissions, is generally not true. The scientific evidence shows that carbon efficiencies elsewhere in the supply chain may more than offset the emissions associated with transportation. Indeed, the effective inclusion of low income countries in labelling schemes may offer important opportunities for carbon emission reductions due to their favourable climactic conditions and their current use of low energy intensive production techniques. The disadvantages of small size can be reduced by carbon labelling schemes that use innovative solutions to low cost data collection and certification.carbon labelling; exports; low income countries;

Evaluating multiagency interventions for children living with intimate partner violence in Birmingham

This research endeavour was born out of the need for a systematic evaluation of the efficacy of the multiagency Domestic Abuse Risk Assessment tool, which necessitates that all incidents of ‘domestic abuse’ (any incident within the family domain) reported to West Midlands Police, where a child or unborn child resides within that home, are scrutinised by Police and Social Care (and partners from Health, Education and the voluntary sector where possible) using a joint protocol. The primary purpose of the protocol is to promote safeguarding and provide a timely and appropriate response to children at risk following domestic abuse. The protocol incorporates the Banardos’ Multiagency Domestic Violence Risk Identification Threshold Scales (MDVRITS), which aids decision making about appropriate interventions based on predicted risk to children using a four level scale

Point of Care Testing: A Discipline that is Growing

Traditionally, diagnostic testing is carried out on patients’ samples ( blood, urine etc) in pathology laboratories by skilled scientists. Transport to the laboratory and subsequent processing (often in batches) can sometimes lead to long turnaround times for the patient and the clinician. Point of Care (POC) or ‘near patient’ testing refers to testing and reporting at the site of patient care and is usually undertaken by non-laboratory personnel. POC technology has a number of attractions as there is a fast turnaround time and this can have enormous benefits for the patient and the clinician

Storied learning from the personal and professional lives of leaders: narrative analyses of rhythm over balance, and adult development and transition

This research study is about using the power of stories, specifically life history and narrative research approaches, to understand how three high level organizational leaders, or elites, experience their own development over time. Readers who will likely find this research study of value will be those studying life history and narrative approaches to understanding the meaning of lives, adult education and adult development scholars and practitioners interested in narrative as a method of adult development, and readers interested in understanding leaders\u27 lives.;A life history of each of the three elites was collected. The life story section of this research study includes a discussion around the dynamics of representation, voice, subjectivity, researcher-researched relationships, and ethics. Common themes in the lives of these three leaders were strong families of origin, support and mentoring, conversation and debate, and risk and adventure.;Two exciting subtexts emerged out of the life story research. The first subtext was around the notion of living a balanced life. The leaders discuss the pace of their lives, their personal and professional identities, and their desire to live with commitment and purpose. Based on an analysis of the leaders\u27 narratives, the goal of living with balance is reconceptualized to a paradigm of rhythm where chaos and complexity move together.;The second subtext is more directly related to adult development and adult learning. The most significant contribution of the entire research study may well be the narratives of development, transition, and learning documented over five years with one leader. Her developmental story, accompanied by an in-depth methodological and theoretical narrative analyses, contributes to the theory of narrative AS adult development and adult learning. This theory is critiqued and improved upon as a result of this research. This chapter also includes an analysis of the research relationship with questions of therapy or listening, friendship or relationship, and her story or my story

Study of Supportive Housing in Illinois: First Interim Report

In particular, the study focuses on the change in service use and the cost of services used by Illinois supportive housing residents 2 years before entering supportive housing and 2 years after. This study will inform policymakers, funders, and others about the importance and cost effectiveness of supportive housing in Illinois