The properties and environment of primitive solar nebulae as deduced from observations of solar-type pre-main sequence stars

The following topics were discussed: (1) current observation evidence for the presence of circumstellar disks associated with solar type pre-main sequence (PMS) stars; (2) the properties of such disks; and (3) the disk environment

The evolution of young stellar object disks and their environment

The main efforts were directed towards determining the frequency of disk occurrence and the timescales for disk evolution for solar-type and intermediate mass stars. The results of the investigation showed that optically thick disks are accretion disks. The projected accomplishments are also discussed

Valuing Immature Grain Crops as Forage

Late planted corn, soybeans and oats crops can be harvested as forages instead of for grain. Options include corn or oat silage, earlage, and oat or soybean hay. Estimating a value for these crops is made difficult by the fact there are few reported prices or significant markets in which they are bought and sold. However, there are two other general approaches to valuing grain crops harvested as forage. Both are based on comparisons to alternative actions by either the forage buyer or seller

Cenozoic evolution of the eastern Black Sea: a test of depth-dependent stretching models

Subsidence analysis of the eastern Black Sea basin suggests that the stratigraphy of this deep, extensional basin can be explained by a predominantly pure-shear stretching history. A strain-rate inversion method that assumes pure-shear extension obtains good fits between observed and predicted stratigraphy. A relatively pure-shear strain distribution is also obtained when a strain-rate inversion algorithm is applied that allows extension to vary with depth without assuming its existence or form. The timing of opening of the eastern Black Sea, which occupied a back-arc position during the closure of the Tethys Ocean, has also been a subject of intense debate; competing theories called for basin opening during the Jurassic, Cretaceous or Paleocene/Eocene. Our work suggests that extension likely continued into the early Cenozoic, in agreement with stratigraphic relationships onshore and with estimates for the timing of arc magmatism. Further basin deepening also appears to have occurred in the last 20 myr. This anomalous subsidence event is focused in the northern part of the basin and reaches its peak at 15–10 Ma. We suggest that this comparatively localized shortening is associated with the northward movement of the Arabian plate. We also explore the effects of paleowater depth and elastic thickness on the results. These parameters are controversial, particularly for deep-water basins and margins, but their estimation is a necessary step in any analysis of the tectonic subsidence record stored in stratigraphy. <br/

Improving Livelihoods through Youth-Adult Partnerships involving School-based,Agripreneurship Projects: The Experiences of Adult Partners in Uganda

The increasing number of unemployed and underemployed youth across the globe, especially indeveloping countries, has reached alarming levels. In Africa, for example, this phenomenon hasled to some youth making treacherous journeys across the Mediterranean Sea to Europe and other parts of the world in search of better livelihoods. Such an influx of immigrants, primarily to Europe and North America, has caused resentment and outcries by many citizens of the affected nations. Some of these challenges, however,could be allayed by engaging youth in income-generating projects, including agricultural entrepreneurship, i.e., agripreneurship,tocreate jobs and improve livelihoods. This maybe achieved through Youth-Adult Partnerships (Y-APs) by which youth and adults work together on agricultural projects of mutual interest. This study explored the experiences of adult partners in Uganda who collaborated with youth on their school-based, agripreneurial projects (SAPs) involving the raising of broiler chickens. Because of their partnership working on SAPs, both the youths’and adults’ knowledge and understanding of concepts related to agripreneurship and raising of broilers chickens improved. The need exists to provide an enabling environment to promote an agripreneurial culture among youth through Y-APs if we seek to inspire them to pursue agripreneurship and related opportunities for job creation while also enabling the food security of communities and improved livelihoods for their citizens

Still\u27s Disease in Adults

In 1897, Dr. George F. Still described 22 children with a form of chronic joint disease which differed from rheumatic fever. Twelve of these children had a syndrome characterized by glandular and splenic enlargement which, with a characteristic fever pattern, rash, and arthritis, has become known as Still\u27s disease. Subsequent investigators have described patients over age 16 presenting with similar signs and symptoms suggesting that this syndrome is not specific for children. We recently studied a patient in whom the diagnosis of adult onset Still\u27s disease was made

Nerve Agent Hydrolysis Activity Designed into a Human Drug Metabolism Enzyme

Organophosphorus (OP) nerve agents are potent suicide inhibitors of the essential neurotransmitter-regulating enzyme acetylcholinesterase. Due to their acute toxicity, there is significant interest in developing effective countermeasures to OP poisoning. Here we impart nerve agent hydrolysis activity into the human drug metabolism enzyme carboxylesterase 1. Using crystal structures of the target enzyme in complex with nerve agent as a guide, a pair of histidine and glutamic acid residues were designed proximal to the enzyme's native catalytic triad. The resultant variant protein demonstrated significantly increased rates of reactivation following exposure to sarin, soman, and cyclosarin. Importantly, the addition of these residues did not alter the high affinity binding of nerve agents to this protein. Thus, using two amino acid substitutions, a novel enzyme was created that efficiently converted a group of hemisubstrates, compounds that can start but not complete a reaction cycle, into bona fide substrates. Such approaches may lead to novel countermeasures for nerve agent poisoning