Environmental justice, capabilities, and the theorization of well-being

Environmental justice (EJ) scholarship is increasingly framing justice in terms of capabilities. This paper argues that capabilities are fundamentally about well-being and as such there is a need to more explicitly theorize well-being. We explore how capabilities have come to be influential in EJ and how well-being has been approached so far in EJ specifically and human geography more broadly. We then introduce a body of literature from social psychology which has grappled theoretically with questions about well-being, using the insights we gain from it to reflect on some possible trajectories and challenges for EJ as it engages with well-being

Phenolic metabolites of anthocyanins modulate mechanisms of endothelial function

Anthocyanins are reported to have vascular bioactivity, however their mechanisms of action are largely unknown. Evidence suggests that anthocyanins modulate endothelial function, potentially by increasing nitric oxide (NO) synthesis, or enhancing NO bioavailability. This study compared the activity of cyanidin-3-glucoside, its degradation product protocatechuic acid, and phase II metabolite, vanillic acid. Production of NO and superoxide and expression of endothelial NO synthase (eNOS), NADPH oxidase (NOX), and heme oxygenase-1 (HO-1) were established in human vascular cell models. Nitric oxide levels were not modulated by the treatments, although eNOS was upregulated by cyanidin-3-glucoside, and superoxide production was decreased by both phenolic acids. Vanillic acid upregulated p22phox mRNA but did not alter NOX protein expression, although trends were observed for p47phox downregulation and HO-1 upregulation. Anthocyanin metabolites may therefore modulate vascular reactivity by inducing HO-1 and modulating NOX activity, resulting in reduced superoxide production and improved NO bioavailability

A response to Hackethal and Schmidt (2003) "Financing patterns: measurement concepts and empirical results"

Hackethal and Schmidt (2003) criticize a large body of literature on the financing of corporate sectors in different countries that questions some of the distinctions conventionally drawn between financial systems. Their criticism is directed against the use of net flows of finance and they propose alternative measures based on gross flows which they claim re-establish conventional distinctions. This paper argues that their criticism is invalid and that their alternative measures are misleading. There are real issues raised by the use of aggregate data but they are not the ones discussed in Hackethal and Schmidt’s paper. JEL Classification: G3

Nutritional Disorders of Grain Sorghum

Crop Production/Industries,

NASA Field Center Governance: An examination of NASA’s funding – mission mismatch, organizational rigidity, and the proposed solution of transitioning field centers to the Federally Funded Research and Development Center (FFRDC) model

This paper seeks to identify the budgetary and structural changes in the Agency and changes in the political environment that highlight the development of a misalignment between these variables and the Agency’s current mission and purpose. NASA’s missions and strategic goals have expanded since the Apollo era. However, its budget has substantially decreased in real dollars and as a percent of federal expenditures. The alignment of presidential and congressional vision is also largely diminished. Finally, the Agency’s infrastructure and organizational structure remain essentially the same as it was 50 years ago. Highlighting this disconnect will proceed through an examination of 1) the Agency’s budget decline; 2) historical changes in its organizational model, highlighting the rigidity of NASA’s management structure; 3) a discussion of the changes in political discourse concerning the Agency and the competing priorities of political parties and branches of government; and 4) an analysis of NASA stakeholders’ values and objectives, and each group’s power to and interest in determining NASA’s organizational structure. This paper will then explore one of many potential solutions to some of NASA’s problems that periodically crops up in executive-level discussions of NASA’s performance; transitioning NASA field centers to a Federally Funded Research and Development Center (FFRDC) model. This exploration will begin by defining, providing the history and genesis of, and the legal basis for FFRDCs. Following, is an examination of variations in the FFRDC model, possible variations of implementation, an analysis of the advantages and disadvantages of converting field centers to FFRDCs, and an examination of the barriers to implementation. A summary and final recommendation will then be provided based on this comprehensive analysis.No embargoAcademic Major: Public Policy Analysi

Evaluation of a tumor microenvironment-based prognostic score in primary operable colorectal cancer

Purpose: The tumor microenvironment is recognized as an important determinant of progression and outcome in colorectal cancer. The aim of the present study was to evaluate a novel tumor microenvironment–based prognostic score, based on histopathologic assessment of the tumor inflammatory cell infiltrate and tumor stroma, in patients with primary operable colorectal cancer. Experimental Design: Using routine pathologic sections, the tumor inflammatory cell infiltrate and stroma were assessed using Klintrup–Mäkinen (KM) grade and tumor stroma percentage (TSP), respectively, in 307 patients who had undergone elective resection for stage I–III colorectal cancer. The clinical utility of a cumulative score based on these characteristics was examined. Results: On univariate analysis, both weak KM grade and high TSP were associated with reduced survival (HR, 2.42; P = 0.001 and HR, 2.05; P = 0.001, respectively). A cumulative score based on these characteristics, the Glasgow Microenvironment Score (GMS), was associated with survival (HR, 1.93; 95% confidence interval, 1.36–2.73; P < 0.001), independent of TNM stage and venous invasion (both P < 0.05). GMS stratified patients in to three prognostic groups: strong KM (GMS = 0), weak KM/low TSP (GMS = 1), and weak KM/high TSP (GMS = 2), with 5-year survival of 89%, 75%, and 51%, respectively (P < 0.001). Furthermore, GMS in combination with node involvement, venous invasion, and mismatch repair status further stratified 5-year survival (92% to 37%, 93% to 27%, and 100% to 37%, respectively). Conclusions: The present study further confirms the clinical utility of assessment of the tumor microenvironment in colorectal cancer and introduces a simple, routinely available prognostic score for the risk stratification of patients with primary operable colorectal cancer