19 research outputs found
Histological Features of Pseudotumor-like Tissues From Metal-on-Metal Hips
Pseudotumor-like periprosthetic tissue reactions around metal-on-metal (M-M) hip replacements can cause pain and lead to revision surgery. The cause of these reactions is not well understood but could be due to excessive wear, or metal hypersensitivity or an as-yet unknown cause. The tissue features may help distinguish reactions to high wear from those with suspected metal hypersensitivity.
We therefore examined the synovial lining integrity, inflammatory cell infiltrates, tissue organization, necrosis and metal wear particles of pseudotumor-like tissues from M-M hips revised for suspected high wear related and suspected metal hypersensitivity causes.
Tissue samples from 32 revised hip replacements with pseudotumor-like reactions were studied. A 10-point histological score was used to rank the degree of aseptic lymphocytic vasculitis-associated lesions (ALVAL) by examination of synovial lining integrity, inflammatory cell infiltrates, and tissue organization. Lymphocytes, macrophages, plasma cells, giant cells, necrosis and metal wear particles were semiquantitatively rated. Implant wear was measured with a coordinate measuring machine. The cases were divided into those suspected of having high wear and those suspected of having metal hypersensitivity based on clinical, radiographic and retrieval findings. The Mann-Whitney test was used to compare the histological features in these two groups.
The tissues from patients revised for suspected high wear had a lower ALVAL score, fewer lymphocytes, but more macrophages and metal particles than those tissues from hips revised for pain and suspected metal hypersensitivity. The highest ALVAL scores occurred in patients who were revised for pain and suspected metal hypersensitivity. Component wear was lower in that group.
Pseudotumor-like reactions can be caused by high wear, but may also occur around implants with low wear, likely because of a metal hypersensitivity reaction. Histologic features including synovial integrity, inflammatory cell infiltrates, tissue organization, and metal particles may help differentiate these causes.
Painful hips with periprosthetic masses may be caused by high wear, but if this can be ruled out, metal hypersensitivity should be considered
Site-Specific Diagnostic Evaluation of Hard Biological Tissues Using Solitary Waves
We perform site-specific diagnostic evaluation of hard biological tissues via highly nonlinear solitary waves. Solitary waves are compact-supported tunable pulses with extremely high energy density, which can be efficiently formed in a chain of ordered granular particles defined as 1D granular crystals. We transmit a single pulse of solitary waves into specific areas of artificial biological systems via direct mechanical contact with a granular crystal sensor. We then record the solitary waves backscattered from a targeted bone area to assess its mechanical stiffness. By taking advantage of the coupling between nonlinear granular media and biological systems, we demonstrate that reflected solitary waves are highly sensitive to site-specific mechanical properties of hard biological tissues. The efficacy of the diagnostic approach is investigated by comparing the stiffness measurements with nominal elastic moduli of polyurethane foams that mimic osteoporotic bone. We also perform numerical investigations via a discrete element (DE) model, simulating propagation and attenuation of solitary waves at the interfaces. The site-specific evaluation technique via solitary waves has the potential for clinical applications, such as assisting appropriate intraoperative decision during joint replacement or spinal surgery for better surgical outcome
Recommended from our members
Temporal relation of meniscal tear incidence, severity, and outcome scores in adolescents undergoing anterior cruciate ligament reconstruction
PurposeAnterior cruciate ligament (ACL) rupture is increasingly common in adolescents. Time between ACL rupture and surgical reconstruction, surgical wait time, is related to concurrent meniscal tear incidence and possibly tear pattern. This study defines the relationship between meniscal tear characteristics and surgical wait time in adolescents with ACL rupture.MethodsOne-hundred and twenty-one consecutive adolescent (median age 16.1 years, range 9-19 years) ACL rupture patients undergoing primary ACL reconstruction were studied. All had documented surgical wait time, preoperative and 6-month post-operative outcome (Lysholm and pedi-IKDC) scores, and intraoperative meniscus tear characteristics. Meniscal tear severity was graded according to the Lawrence and Anderson system: non-surgical: grade 1; reparable: grade 2-3; irreparable: grade 4-5. Significant tears were defined as at least grade 2.ResultsAverage age at surgery was 16.1 years. 48.7 % had surgical wait time greater than 6 months. 42.5 % of menisci were torn. With surgical wait time <6 months, there were more lateral than medial tears (48 vs 21 %, p = 0.001). With surgical wait time >6 months, medial tear incidence increased (50 vs 21 %, p < 0.001), there were more significant tears (63 vs 42 %, OR 2.3, p = 0.02), and preoperative Lysholm and pedi-IKDC scores were lower (58 vs 74, p < 0.001; 52 vs 61, p < 0.007). Scores were lower in patients with meniscus tears (63.8 vs 69.3, n.s.; 53.9 vs 60.5, p = .04). Patients with public insurance had risks of surgical wait time greater than 3 months (OR 12.4, p < 0.001) and 6 months (OR 7.8, p < 0.001), and of a significant meniscus tear (OR 2.5, p = 0.03). Six-month post-operative pedi-IKDC scores improved more in meniscus tear patients (28.4 vs 21, p = 0.05).ConclusionsThis study shows a significant increase in medial meniscal tear incidence, decrease in preoperative scores, and worse tear severity with surgical wait time >6 months. Public insurance was a risk factor for longer surgical wait time and meniscus tear
Can severity of trunnion damage be estimated by visual inspection alone?: introduction of an enhanced visual grading system and validation using metrology
Aims: Taper corrosion has been widely reported to be problematic for modular total hip arthroplasty implants. A simple and systematic method to evaluate taper damage with sufficient resolution is needed. We introduce a semiquantitative grading system for modular femoral tapers to characterize taper corrosion damage. Methods: After examining a unique collection of retrieved cobalt-chromium (CoCr) taper sleeves (n = 465) using the widely-used Goldberg system, we developed an expanded six-point visual grading system intended to characterize the severity, visible material loss, and absence of direct component contact due to corrosion. Female taper sleeve damage was evaluated by three blinded observers using the Goldberg scoring system and the expanded system. A subset (n = 85) was then re-evaluated following destructive cleaning, using both scoring systems. Material loss for this subset was quantified using metrology and correlated with both scoring systems. Results: There was substantial agreement in grading among all three observers with uncleaned (n = 465) and with the subset of cleaned (n = 85) implants. The expanded scoring criteria provided a wider distribution of scores which ultimately correlated well with corrosion material loss. Cleaning changed the average scores marginally using the Goldberg criteria (p = 0.290); however, using the VGS, approximately 40% of the scores for all observers changed, increasing the average score from 4.24 to 4.35 (p = 0.002). There was a strong correlation between measured material loss and new grading scores. Conclusion: The expanded scoring criteria provided a wider distribution of scores which ultimately correlated well with corrosion material loss. This system provides potential advantages for assessing taper damage without requiring specialized imaging devices. Cite this article: Bone Joint Res 2023;12(3):155–164
Site-specific Quantification of Bone Quality using Highly Nonlinear Solitary Waves
Osteoporosis is a well recognized problem affecting millions of individuals
worldwide. Consequently, the need to effectively, efficiently, and affordably
diagnose and identify those at risk is essential; moreover, site-specific
assessment of bone quality is necessary, not only in the process of risk
assessment, but may also be desirable for other applications. The present study
evaluated a new one-dimensional granular crystal sensor, composed of a tightly
packed chain of beads under Hertzian contact interaction, representing the most
suitable fundamental component for solitary wave generation and propagation.
First, the sensitivity of the novel sensor was tested using densities of rigid
polyurethane foam, representing clinical bone quality ranging from healthy, to
severely osteoporotic. Once the relationship between the signal response and
known densities was established, the sensor was used to measure several sites
located in the proximal femur of ten human cadaveric specimens. The accuracy of
the model was then further investigated, using measurements of bone quality
from the same cadaveric specimens, independently, using DEXA. The results
indicate not only that the novel technique is capable of detecting differences
in bone quality, but that the ability to measure site-specific properties
without exposure to radiation, has the potential to be further developed for
clinical applications.Comment: This paper has been withdrawn to make it update