Characteristics of Duplicate Records in OCLC's Online Union Catalog

Duplicate records in the Online Union Catalog of the OCLC Online Computer Library Center, Inc., were analyzed. Bibliographic elements comprise information found in one or more fields of a bibliographic record; e.g., the author element comprises the main and added author entry fields. Bibliographic element mismatches in duplicate record pairs were considered relative to the number of records in which each element was present. When a single element differed in a duplicate record pair, that element was most often publication date. This finding shows that a difference in the date of publication is not a reliable indicator of bibliographic uniqueness. General cataloging and data entry patterns such as variations in title transcription and form of name, typographical errors, mistagged fields, misplaced subfield codes, omissions, and inconsistencies between fixed and variable fields often caused records that were duplicates to appear different. These factors can make it extremely difficult for catalogers to retrieve existing bibliographic records and thus avoid creating duplicate records. They also prevent duplicate detection algorithms used for tape-loading records from achieving desired results. An awareness of particularly problematic bibliographic elements and general factors contributing to the creation of duplicate records should help catalogers identify and accept existing records more often. This awareness should also help to direct system designers in their development of more sensitive algorithms to be used for tape loading. The resulting general reduction in the number of duplicate records in union catalogs will be a major step toward increased cataloger productivity, user satisfaction, and overall online database quality

Hubble Space Telescope Planetary Camera images of R136

The Planetary Camera of the Hubble Space Telescope has been used to obtain broad and narrowband images ofR136, the core of the massive star cluster 30 Doradus in the Large Magellanic Cloud. R136a, the brightest component ofR136, is shown to have at least 12 separate components, including the eight originally identified by speckle interferometry. Three of the 12 components are previously unidentified close companions of the speckle components. The stars within R136a are found to have luminosities and colors of normal evolved (Wolf-Rayet and blue supergiants) and zero-age main-sequence (ZAMS) massive stars. A narrowband He II filter was used to investigate the Wolf-Rayet stellar population. We find that three stars in R136a are of the Wolf-Rayet type; of the two identified from ground-based data, one is now resolved into two components. We present color-magnitude diagrams and a luminosity function of the stars within the larger region (~2 pc) defined as R136. We find that the stars in R136 are similar in color and luminosity to those of cluster members that lie outside that crowded inner region. The lower end of the color-magnitude diagram corresponds to ZAMS spectral type B3. No red supergiants have been detected within R136. The luminosity per unit area in the inner 1" (0.25 pc) of R136 is ≥ 50 times that of the center of Orion for a comparable area and seven times that of the core of NGC 3603. The luminosity per unit area of all of R136 is comparable to that of Orion but is sustained over 130 times the area. An F336W surface brightness profile is constructed for R136 based on the stellar photometry. The distribution is found to be consistent with a pure power law with l(r}ɑ r^y with y=-1.72±0.06 or with a small core with r_c 5 X 10^4 M_☉ pc^(-3). The implied upper limit on the relaxation time for the cluster is much smaller than the age of 3.5 X 10^6 yrs required by the presence of Wolf-Rayet stars. This suggests that relaxation effects have been very important in determining the observed structure of the cluster unless a large population of lower mass stars is also present

Hubble Space Telescope imaging of η Carinae

We present new high spatial resolution observations of the material around η Carinae obtained with the Hubble Space Telescope Wide Field/Planetary Camera. The star η Carinae is one of the most massive and luminous stars in our Galaxy, and has been episodically expelling significant quantities of gas over the last few centuries. The morphology of the bright central nebulosity (the homunculus) indicates that it is a thin shell with very well defined edges, and is clumpy on 0".2 (~10^(16)cm) scales. An extension to the northeast of the star {NN/NS using Walborn's [ApJL, 204, L17 ( 1976)] nomenclature} appears to be a stellar jet and its associated bow shock. The bow shock is notable for an intriguing series of parallel linear features across its face. The S ridge and the W arc appear to be part of a "cap" of emission located to the SW and behind the star. Together, the NE jet and the SW cap suggest that the symmetry axis for the system runs NE-SW rather than SE-NW, as previously supposed. Overall, the data indicate that the material around the star may represent an oblate shell with polar blowouts, rather than a bipolar flow

Risk Factors for Age-Related Maculopathy

Age-related maculopathy (ARM) is the leading cause of blindness in the elderly. Although beneficial therapeutic strategies have recently begun to emerge, much remains unclear regarding the etiopathogenesis of this disorder. Epidemiologic studies have enhanced our understanding of ARM, but the data, often conflicting, has led to difficulties with drawing firm conclusions with respect to risk for this condition. As a consequence, we saw a need to assimilate the published findings with respect to risk factors for ARM, through a review of the literature appraising results from published cross-sectional studies, prospective cohort studies, case series, and case control studies investigating risk for this condition. Our review shows that, to date, and across a spectrum of epidemiologic study designs, only age, cigarette smoking, and family history of ARM have been consistently demonstrated to represent risk for this condition. In addition, genetic studies have recently implicated many genes in the pathogenesis of age-related maculopathy, including Complement Factor H, PLEKHA 1, and LOC387715/HTRA1, demonstrating that environmental and genetic factors are important for the development of ARM suggesting that gene-environment interaction plays an important role in the pathogenesis of this condition

Planetary camera observations of the central parsec of M32

Analysis of V band HST Planetary Camera images of the elliptical galaxy M32 shows that its nucleus is extremely dense and remains unresolved at even the HST diffraction limit. A combined approach of image deconvolution and model fitting is used to investigate the starlight distribution into limiting radii of 0".04 (0.14 pc at 700 kpc). The logarithmic slope of the brightness profile smoothly flattens from y= -1.2 at 3.4 pc to y= -0.5 at 0.34 pc; interior to this radius the profile is equally consistent with a singular µ(r)∝ r,^(-1/2) cusp or a small nonisothermal core with r_c<0.37 pc. The isophotes maintain constant ellipticity into tlle center, and there is no evidence for a central point source, disk, dust, or any other substructures. The cusp model implies central mass densities p_0 > 3 X 10^7 M_☉ pc^(-3) at the resolution limit and is consistent with a central M_• = 3 X 10^6 M_☉ black hole; the core model implies p_0≈4 X 10^6 M_☉ pc^(-3). From the viewpoint of long-term stability, we argue that a starlight cusp surrounding a central black hole is the more plausible interpretation of the observations. A core at the implied density and size without a black hole has a relaxation time of only ~7 X 10^7 yr and a short stellar oollision timescale implying wholesale stellar merging over the age of the universe. The core would be strongly vulnerable to collapse and concomitant runaway stellar merging. Collapse may lead to formation of a massive black hole in any case if it cannot be reversed by formation of a binary from high-mass merger products. Regardless of the ultimate fate of the core, however, structural evolution of the core will always be accompanied by strong evolution of the core population-the constant isophote shape and absence of a central color gradient appear to show that such evolution has not occurred. In contrast, the high velocities around a black hole imply long relaxation and stellar collision times for the cusp population compared to the age of the universe

Imaging of the gravitational lens system PG 1115+080 with the Hubble Space Telescope

This paper is the first of a series presenting observations of gravitational lenses and lens candidates, taken with the Wide Field/Planetary Camera (WFPC) of the Hubble Space Telescope (HST). We have resolved the gravitational lens system PG 1115 + 080 into four point sources and a red, extended object that is presumably the lens galaxy; we present accurate relative intensities, colors, and positions of the four images, and lower accuracy intensity and position of the lens galaxy, all at the epoch 1991.2. Comparison with earlier data shows no compelling evidence for relative intensity variations between the QSO components having so far been observed. The new data agree with earlier conclusions that the system is rather simple, and can be produced by the single observed galaxy. The absence of asymmetry in the HST images implies that the emitting region of the quasar itself has an angular radius smaller than about 10 milliarcsec (100 pc for H_0=50, q_0=0.5)

Second-generation nitazoxanide derivatives: thiazolides are effective inhibitors of the influenza A virus

Aim: The only small molecule drugs currently available for treatment of influenza A virus (IAV) are M2 ion channel blockers and sialidase inhibitors. The prototype thiazolide, nitazoxanide, has successfully completed Phase III clinical trials against acute uncomplicated influenza. Results: We report the activity of seventeen thiazolide analogs against A/PuertoRico/8/1934(H1N1), a laboratory-adapted strain of the H1N1 subtype of IAV, in a cell culture-based assay. A total of eight analogs showed IC50s in the range of 0.14–5.0 μM. Additionally a quantitative structure–property relationship study showed high correlation between experimental and predicted activity based on a molecular descriptor set. Conclusion: A range of thiazolides show useful activity against an H1N1 strain of IAV. Further evaluation of these molecules as potential new small molecule therapies is justified