Tretti nye norske pyrenomycetoide sekksporesopp-arter fra workshop i Horten 2.-5. mai 2023.

During a workshop with invited international experts, we found 30 pyrenomycetoid ascomycete species new to Norway, whereof 16 new to Scandinavia and one new to Europe. These are presented here with short notes on their micromorphology, ecology, and occurrence in Fennoscandia, some also with photos. Ascomycota, bark-inhabiting, wood-inhabiting, plant-inhabiting, pyrenomycetes, pyrenomycetoid fungi, Sekksporesopper, barklevende, vedlevende, plantelevende, pyrenomyceter, pyrenomycetoide soppTretti nye norske pyrenomycetoide sekksporesopp-arter fra workshop i Horten 2.-5. mai 2023.publishedVersio

In Vivo pH imaging with \u3csup\u3e99m\u3c/sup\u3eTc-pHLIP

Purpose: A novel molecular imaging agent has been developed recently, which stains tissues of low extracellular pH [pH (low) insertion peptide, pHLIP®]. A pH-dependent process of peptide folding and insertion into cell membranes has been found in vitro. Targeting of acidic solid tumours has been demonstrated in vivo using fluorescence and PET labels. Here, we present proof of feasibility studies of pHLIP with a single-photon emission computed tomography (SPECT) label, 99mTc-AH114567, with focus on preclinical efficacy and imageability. Procedures: Lewis lung carcinoma, lymph node carcinoma of the prostate and prostate adenocarcinoma tumour xenografts were grown in mice and characterised by the angiogenesis marker 99mTc- NC100692 and by extracellular pH measurements with 31P-MRS of 3-aminopropyl phosphonate. Biodistribution was assessed and CT/SPECT imaging performed. Oral administration of bicarbonate served as control. Results and Conclusion: Tc-AH114567 can be obtained via a robust synthesis with good radiolabelling profile and improved formulation. The tracer retains the pH-dependent ability to insert into membranes and to target tumours with similar pharmacokinetics and efficacy that had been demonstrated earlier for pHLIP with optical or 64Cu PET labels. Despite the inherent challenges of SPECT compared to optical and PET imaging, e.g., in terms of lower sensitivity, 99mTc-AH114567 shows adequate image quality and contrast. The main development need for transitioning SPECT labelled pHLIP into the clinic is more rapid background signal reduction, which will be the focus of a subsequent optimisation study. © World Molecular Imaging Society, 2011

Fish investigations in the Barents Sea Winter 2023

Preface Annual catch quotas and other regulations of the Barents Sea fisheries are set through negotiations between Norway and Russia. Assessment of the state of the stocks and quota advice are given by the International Council for the Exploration of the Sea (ICES). Their work is based on survey results and international landings statistics. The results from the demersal fish winter surveys in the Barents Sea are an important source of information for the annual stock assessment. The development of the survey started in the early 1970s and focused on acoustic measurements of cod and haddock. Since 1981 it has been designed to produce both acoustic and swept area estimates of fish abundance. Some development has taken place since then, both in area coverage and in methodology. The development is described in detail by Jakobsen et al . (1997), Johannesen et al . (2009) and in Appendix 3, and the current survey design and methods for survey index calculation are presented in Appendix 2. The survey manual is available at the internal IMR quality portal here. At present the survey provides the main data input for several ongoing projects at the Institute of Marine Research, Bergen: monitoring abundance of the Barents Sea demersal fish stocks mapping fish distribution in relation to climate and prey abundance monitoring food consumption and growth estimating predation mortality caused by cod This report presents the main results from the surveys in January-March 2023. The surveys were performed with the Norwegian research vessels “Kronprins Haakon” and “Johan Hjort”, and the Russian research vessel “Vilnyus”. Annual survey reports since 1981 are listed in Appendix 5, and names of scientific participants in 2023 are given in Appendix 4.Fish investigations in the Barents Sea Winter 2023publishedVersio

Oversikt over fiskeri- og prøvetaking i botnfisksektoren i 2023 — torsk, hyse (NØA), sei, blåkveite, pigghå og reker (Norskerenna og Skagerrak)

publishedVersio

In Vivo pH Imaging with 99mTc-pHLIP

PURPOSE: A novel molecular imaging agent has been developed recently which stains tissues of low extracellular pH (pH (low) insertion peptide, pHLIP(®)). A pH-dependent process of peptide folding and insertion into cell membranes has been found in vitro. Targeting of acidic solid tumours has been demonstrated in vivo using fluorescence and PET labels. Here we present proof of feasibility studies of pHLIP with a SPECT label, (99m)Tc-AH114567, with focus on preclinical efficacy and imageability. PROCEDURES: LLC, LNCaP and PC-3 tumour xenografts were grown in mice and characterised by the angiogenesis marker (99m)Tc-NC100692 and by extracellular pH measurements with (31)P-MRS of 3-aminopropyl phosphonate. Biodistribution was assessed and CT/SPECT imaging performed. Oral administration of bicarbonate served as control. RESULTS AND CONCLUSION: (99m)Tc-AH114567 can be obtained via a robust synthesis with good radiolabelling profile and improved formulation. The tracer retains the pH-dependent ability to insert into membranes and to target tumours with similar pharmacokinetics and efficacy that had been demonstrated earlier for pHLIP with optical or (64)Cu PET labels. Despite the inherent challenges of SPECT compared to optical and PET imaging e.g. in terms of lower sensitivity, (99m)Tc-AH114567 shows adequate image quality and contrast. The main development need for transitioning SPECT labelled pHLIP into the clinic is more rapid background signal reduction which will be the focus of a subsequent optimization study