9 research outputs found
The CIITA genetic polymorphism rs4774*C in combination with the HLA-DRB1*15:01 allele as a putative susceptibility factor to multiple sclerosis in Brazilian females
The CIITA genetic polymorphism rs4774*C in combination with the HLA-DRB1*15:01 allele as a putative susceptibility factor to multiple sclerosis in Brazilian females
The objective of this study was to investigate the association between the HLA alleles at the DQA1, DQB1 and DRB1 loci, the CIITA genetic polymorphisms -168A/G and +1614G/C, and susceptibility to multiple sclerosis (MS) in a sample from Rio de Janeiro State, Brazil. Furthermore, we wished to determine whether any of these associations might be more significant in women compared with men. DNA samples from 52 relapsing-remitting MS (RRMS) patients and 126 healthy controls matched for sex and age were analyzed. We identified a significant HLA-DRB1*15:01-MS association that was female-specific (Odds Ratio (OR) = 4.78; p = 0.001). Furthermore, we observed that the +1614G/C mutation in combination with the HLA-DRB1*15:01 allele increased susceptibility to MS in females (OR = 4.55; p = 0.01). Together, these findings highlight the polygenic nature of MS
Erratum: Haplotype analysis of the CAG and CCG repeats in 21 Brazilian families with Huntington’s disease
Constatação de Xylella fastidiosa em pecĂolos e hipocotilos de cafeeiro com sintomas de mancha manteigosa
In-depth proteomic characterization of classical and non-classical monocyte subsets
Monocytes are bone marrow-derived leukocytes that are part of the innate immune
system. Monocytes are divided into three subsets: classical, intermediate and non-classical,
which can be differentiated by their expression of some surface antigens, mainly CD14 and CD16.
These cells are key players in the inflammation process underlying the mechanism of many
diseases. Thus, the molecular characterization of these cells may provide very useful information
for understanding their biology in health and disease. We performed a multicentric proteomic
study with pure classical and non-classical populations derived from 12 healthy donors. The robust
workflow used provided reproducible results among the five participating laboratories. Over 5000
proteins were identified, and about half of them were quantified using a spectral counting approach.
The results represent the protein abundance catalogue of pure classical and enriched non-classical
blood peripheral monocytes, and could serve as a reference dataset of the healthy population.
The functional analysis of the differences between cell subsets supports the consensus roles assigned
to human monocytes
In-depth proteomic characterization of classical and non-classical monocyte subsets
Monocytes are bone marrow-derived leukocytes that are part of the innate immune
system. Monocytes are divided into three subsets: classical, intermediate and non-classical,
which can be differentiated by their expression of some surface antigens, mainly CD14 and CD16.
These cells are key players in the inflammation process underlying the mechanism of many
diseases. Thus, the molecular characterization of these cells may provide very useful information
for understanding their biology in health and disease. We performed a multicentric proteomic
study with pure classical and non-classical populations derived from 12 healthy donors. The robust
workflow used provided reproducible results among the five participating laboratories. Over 5000
proteins were identified, and about half of them were quantified using a spectral counting approach.
The results represent the protein abundance catalogue of pure classical and enriched non-classical
blood peripheral monocytes, and could serve as a reference dataset of the healthy population.
The functional analysis of the differences between cell subsets supports the consensus roles assigned
to human monocytes