2,923 research outputs found

    Climate change : a response surface study of the effects of CO2 and temperature on the growth of French beans

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    The possible impact of global rises in atmospheric CO2 concentration and temperature on the growth and development of French beans (Phaseolus vulgaris) was examined using growth cabinets. Five CO2 concentrations of 350, 450, 550, 650 and 750 vpm and five temperatures of 14·5, 15·5, 16·5, 17·5 and 18·5°C were tested using a fractional factorial design comprising nine treatment combinations of the two factors. Plants were grown under constant irradiance, common atmospheric humidities (vpd 0·5 kPa) and non-limiting supplies of water and mineral nutrients. The plant growth response was modelled by fitting polynomial response function curves to the times to first flower opening, first bean set, 50% maturity and the number and yield of beans. The effects of temperature were large and positive for most of the measured variables, whereas the effects of CO2 were small and negative or non-existent. Increased temperature substantially reduced the time to flowering and the time from bean set to 50% maturity and increased the number and yield of mature beans whereas increased CO2 concentration had little effect on plant growth except that bean yield was very slightly reduced. There was no significant evidence of interaction between the CO2 concentration effects and the temperature effects. The time to maturity and yield of mature beans was simulated for the 2020s (2010 to 2039) and the 2050s (2040 to 2069) using the fitted polynomial models and four climate change scenarios suggested by the UK Climate Impacts Programme. These simulations showed that, depending upon the assumed scenario, the 2020s yields could rise by 39–84% and time to maturity reduce by between 6 and 15 days whereas the 2050s yields could rise by 51–118% and time to maturity reduce by between 9 and 25 days

    The human ovarian surface epithelium is an androgen responsive tissue

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    The pathogenesis of epithelial ovarian cancer remains unclear. From epidemiological studies raised levels of androgens have been implicated to increase the risk of developing the disease. The purpose of this study was to determine the responses of normal human ovarian surface epithelium to androgens. We have established primary cultures of human ovarian surface epithelium from patients undergoing oophorectomy for benign disease. Total RNA was isolated from these cultures and expression of mRNA encoding for the androgen receptor was demonstrated using reverse transcriptase polymerase chain reaction. The presence of androgen receptor in sections of normal ovary was also investigated using an antibody against androgen receptor. The effects of androgens on DNA synthesis and cell death were determined. Eight out of eight (100%) cultures expressed mRNA encoding the androgen receptor. The presence of androgen receptor in ovarian surface epithelium of sections of normal ovaries was demonstrated in all sections. Mibolerone, a synthetic androgen, caused a significant stimulation of DNA synthesis in 5 out of 9 (55%) cultures when used at a concentration of 1 nM. Mibolerone also caused a significant decrease in cell death in 2 out of 5 (40%) cultures tested. We have demonstrated that the ovarian surface epithelium is an androgen responsive tissue and that androgens can cause an increase in proliferation and a decrease in cell death. These findings have important implications for the pathophysiology of ovarian carcinogenesis

    Effect of vegetation treatment and water stress on evapotranspiration in bioretention systems

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    EvapotranspirationStormwater managementUrban green infrastructureBioretentionHydrological performanceSustainable Drainage Systems (SuDS

    Formation and Reconnection of Three-Dimensional Current Sheets in the Solar Corona

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    Current-sheet formation and magnetic reconnection are believed to be the basic physical processes responsible for much of the activity observed in astrophysical plasmas, such as the Sun s corona. We investigate these processes for a magnetic configuration consisting of a uniform background field and an embedded line dipole, a topology that is expected to be ubiquitous in the corona. This magnetic system is driven by a uniform horizontal flow applied at the line-tied photosphere. Although both the initial field and the driver are translationally symmetric, the resulting evolution is calculated using a fully three-dimensional magnetohydrodynamic (3D MHD) simulation with adaptive mesh refinement that resolves the current sheet and reconnection dynamics in detail. The advantage of our approach is that it allows us to apply directly the vast body of knowledge gained from the many studies of 2D reconnection to the fully 3D case. We find that a current sheet forms in close analogy to the classic Syrovatskii 2D mechanism, but the resulting evolution is different than expected. The current sheet is globally stable, showing no evidence for a disruption or a secondary instability even for aspect ratios as high as 80:1. The global evolution generally follows the standard Sweet- Parker 2D reconnection model except for an accelerated reconnection rate at a very thin current sheet, due to the tearing instability and the formation of magnetic islands. An interesting conclusion is that despite the formation of fully 3D structures at small scales, the system remains close to 2D at global scales. We discuss the implications of our results for observations of the solar corona. Subject Headings: Sun: corona Sun: magnetic fields Sun: reconnectio

    Cigarette smoking, passive smoking, alcohol consumption, and hearing loss

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    The objective of this large population-based cross-sectional study was to evaluate the association between smoking, passive smoking, alcohol consumption, and hearing loss. The study sample was a subset of the UK Biobank Resource, 164,770 adults aged between 40 and 69 years who completed a speech-in-noise hearing test (the Digit Triplet Test). Hearing loss was defined as speech recognition in noise in the better ear poorer than 2 standard deviations below the mean with reference to young normally hearing listeners. In multiple logistic regression controlling for potential confounders, current smokers were more likely to have a hearing loss than non-smokers (odds ratio (OR) 1.15, 95 % confidence interval (CI) 1.09–1.21). Among non-smokers, those who reported passive exposure to tobacco smoke were more likely to have a hearing loss (OR 1.28, 95 %CI 1.21–1.35). For both smoking and passive smoking, there was evidence of a dose-response effect. Those who consume alcohol were less likely to have a hearing loss than lifetime teetotalers. The association was similar across three levels of consumption by volume of alcohol (lightest 25 %, OR 0.61, 95 %CI 0.57–0.65; middle 50 % OR 0.62, 95 %CI 0.58–0.66; heaviest 25 % OR 0.65, 95 %CI 0.61–0.70). The results suggest that lifestyle factors may moderate the risk of hearing loss. Alcohol consumption was associated with a protective effect. Quitting or reducing smoking and avoiding passive exposure to tobacco smoke may also help prevent or moderate age-related hearing loss

    A Methodology for Post Operational Clean Out of a Highly Active Facility Including Solids Behaviour -12386

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    ABSTRACT The Highly Active Liquor Evaporation and Storage (HALES) plant at Sellafield handles acidic fission product containing liquor with typical activities of the order of 18x10 9 Bq/ml. A strategyexperimental feedback approach has been used to establish a wash regime for the Post Operational Clean Out (POCO) of the oldest storage tanks for this liquor. Two different wash reagents have been identified as being potentially suitable for removal of acid insoluble fission product precipitates. Ammonium carbamate and sodium carbonate yield similar products during the proposed wash cycle. The proposed wash reagents provide dissolution of caesium phosphomolybdate (CPM) and zirconium molybdate (ZM) solid phases but yields a fine, mobile precipitate of metal carbonates from the Highly Active Liquor (HAL) supernate. Addition of nitric acid to the wash effluent can cause CPM to precipitate where there is sufficient caesium and phosphorous available. Where they are not present (from ZM dissolution) the nitric acid addition initially produces a nitrate precipitate which then re-dissolves, along with the metal carbonates, to give a solid-free solution. The different behaviour of the two solids during the wash cycle has led to the proposal for an amended flowsheet. Additional studies on the potential to change the morphology of crystallising ZM have presented opportunities for changing the rheology of ZM sediments through doping with tellurium or particular organic acids

    Climate change: a response surface study of the effects of CO 2

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    The possible impact of global rises in atmospheric CO2 concentration and temperature on the growth and development of French beans (Phaseolus vulgaris) was examined using growth cabinets. Five CO2 concentrations of 350, 450, 550, 650 and 750 vpm and five temperatures of 14·5, 15·5, 16·5, 17·5 and 18·5°C were tested using a fractional factorial design comprising nine treatment combinations of the two factors. Plants were grown under constant irradiance, common atmospheric humidities (vpd 0·5 kPa) and non-limiting supplies of water and mineral nutrients. The plant growth response was modelled by fitting polynomial response function curves to the times to first flower opening, first bean set, 50% maturity and the number and yield of beans. The effects of temperature were large and positive for most of the measured variables, whereas the effects of CO2 were small and negative or non-existent. Increased temperature substantially reduced the time to flowering and the time from bean set to 50% maturity and increased the number and yield of mature beans whereas increased CO2 concentration had little effect on plant growth except that bean yield was very slightly reduced. There was no significant evidence of interaction between the CO2 concentration effects and the temperature effects. The time to maturity and yield of mature beans was simulated for the 2020s (2010 to 2039) and the 2050s (2040 to 2069) using the fitted polynomial models and four climate change scenarios suggested by the UK Climate Impacts Programme. These simulations showed that, depending upon the assumed scenario, the 2020s yields could rise by 39–84% and time to maturity reduce by between 6 and 15 days whereas the 2050s yields could rise by 51–118% and time to maturity reduce by between 9 and 25 days
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