12 research outputs found
Low factor XIII levels after intravenous thrombolysis predict short-term mortality in ischemic stroke patients
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PAI-1 5G/5G genotype is an independent risk of intracranial hemorrhage in post-lysis stroke patients
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Circulating ACE2 activity predicts mortality and disease severity in hospitalized COVID-19 patients
Objectives
Angiotensin-converting enzyme 2 (ACE2) represents the primary receptor for SARS-CoV-2 to enter endothelial cells. Here we investigated circulating ACE2 activity to predict the severity and mortality of COVID-19.
Methods
Serum ACE2 activity was measured in COVID-19 (110 critically ill and 66 severely ill subjects at hospital admission and 106 follow-up samples) and in 32 non-COVID-19 severe sepsis patients. Associations between ACE2, inflammation-dependent biomarkers, pre-existing comorbidities, and clinical outcomes were studied.
Results
Initial ACE2 activity was significantly higher in critically ill COVID-19 patients (54.4 [36.7-90.8] mU/L) than in severe COVID-19 (34.5 [25.2-48.7] mU/L; P<0.0001) and non-COVID-19 sepsis patients (40.9 [21.4-65.7] mU/L; P=0.0260) regardless of comorbidities. Circulating ACE2 activity correlated with inflammatory biomarkers and was further elevated during the hospital stay in critically ill patients. Based on ROC-curve analysis and logistic regression test, baseline ACE2 independently indicated the severity of COVID-19 with an AUC value of 0.701 (95% CI [0.621-0.781], P<0.0001). Furthermore, non-survivors showed higher serum ACE2 activity vs. survivors at hospital admission (P<0.0001). Finally, high ACE2 activity (≥45.4 mU/L) predicted a higher risk (65 vs. 37%) for 30-day mortality (Log-Rank P<0.0001).
Conclusions
Serum ACE2 activity correlates with COVID-19 severity and predicts mortality
Chemotactic activity of bronchoalveolar lavage fluid from children with recurrent obstructive bronchitis
Fibronectin in bronchoalveolar lavage fluid and plasma from children with chronic inflammation of lungs
Fibronectin on the bronchoalveolar surface in children with recurrent obstructive bronchitis
Fibronectin on the bronchoalveolar surface in children with recurrent obstructive bronchitis
A new ELISA method for the measurement of total α2-plasmin inhibitor level in human body fluids
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The effect of factor XIII and other regulators of fibrinolysis on the outcome of thrombolysis in ischemic stroke patients
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