12 research outputs found
Voluntary Medical Male Circumcision: Logistics, Commodities, and Waste Management Requirements for Scale-Up of Services
Dianna Edgil and colleagues evaluate the supply chain and waste management costs needed to deliver mobile medical male circumcision services to 152,000 men in Swaziland, finding that per-procedure costs almost double when these factors are taken into account
Optimising the laboratory supply chain: The key to effective laboratory services
Background: The Supply Chain Management System (SCMS) is a contract managed under the Partnership for Supply Chain Management (PFSCM) consortium by the United States Agency for International Development (USAID). SCMS procures commodities for programmes supported by the US Presidentâs Emergency Plan for AIDS Relief (PEPFAR). From 2005 to mid-2012, PEPFAR, through SCMS, spent approximately 90m was used to purchase flow cytometry technology, largely for flow cytometry platforms and reagents.
Objectives: The purpose of this paper is to highlight the cost differences between low, medium and high utilisation rates of common CD4 testing instruments that have been procured though PEPFAR funding.
Method: A scale of costs per test as a function of test volume through the machine was calculated for the two most common CD4 testing machines used in HIV programmes: Becton Dickinson (BD) FACSCount⢠and BD FACSCaliburâ˘. Instrument utilisation data collected at the facility level in three selected countries were then used to calculate the onsite cost-per-test experienced in each country.
Results: Cost analyses indicated that a target of at least 40% utilisation for FACSCount⢠and 15% utilisation for FACSCaliburâ˘, respectively, closely approach maximal per-test cost efficiency. The average utilisation rate for CD4 testing instruments varies widely by country, level of laboratory and partner (0% â 68%).
Conclusion: Our analysis indicates that, because cost-per-test is related inversely to sample throughput, the underutilisation of flow cytometry machines is resulting in an increase in average cost-per-test for many instruments
Complete Nucleotide Sequence Analysis of a Brazilian Dengue Virus Type 2 Strain
In the last decade, dengue fever (DF) in Brazil has been recognized as
an important public health problem, and an increasing number of dengue
haemorrhagic fever (DHF) cases have been reported since the
introduction of dengue virus type 2 (DEN-2) into the country in 1990.
In order to analyze the complete genome sequence of a DEN-2 Brazilian
strain (BR64022/98), we designed primers to amplify contiguous segments
of approximately 500 base pairs across the entire sequence of the viral
genome. Twenty fragments amplified by reverse transcriptase-PCR were
cloned, and the complete nucleotide and the deduced amino acid
sequences were determined. This constitutes the first complete genetic
characterization of a DEN-2 strain from Brazil. All amino acid changes
differentiating strains related to the Asian/American-Asian genotype
were observed in BR64022/98, indicating the Asiatic origin of the
strain
Cost Analysis of Integrating the PrePex Medical Device into a Voluntary Medical Male Circumcision Program in Zimbabwe
<div><p>Background</p><p>Fourteen African countries are scaling up voluntary medical male circumcision (VMMC) for HIV prevention. Several devices that might offer alternatives to the three WHO-approved surgical VMMC procedures have been evaluated for use in adults. One such device is PrePex, which was prequalified by the WHO in May 2013. We utilized data from one of the PrePex field studies undertaken in Zimbabwe to identify cost considerations for introducing PrePex into the existing surgical circumcision program.</p><p>Methods and Findings</p><p>We evaluated the cost drivers and overall unit cost of VMMC at a site providing surgical VMMC as a routine service (âroutine surgery siteâ) and at a site that had added PrePex VMMC procedures to routine surgical VMMC as part of a research study (âmixed study siteâ). We examined the main cost drivers and modeled hypothetical scenarios with varying ratios of surgical to PrePex circumcisions, different levels of site utilization, and a range of device prices. The unit costs per VMMC for the routine surgery and mixed study sites were 61, respectively. The two greatest contributors to unit price at both sites were consumables and staff. In the hypothetical scenarios, the unit cost increased as site utilization decreased, as the ratio of PrePex to surgical VMMC increased, and as device price increased.</p><p>Conclusions</p><p>VMMC unit costs for routine surgery and mixed study sites were similar. Low service utilization was projected to result in the greatest increases in unit price. Countries that wish to incorporate PrePex into their circumcision programs should plan to maximize staff utilization and ensure that sites function at maximum capacity to achieve the lowest unit cost. Further costing studies will be necessary once routine implementation of PrePex-based circumcision is established.</p></div
Key characteristics of the different implementation models.
<p>The routine surgery site and the hypothetical mixed site employed 1 medical doctor, 6 nurses, 3 theatre assistants, and 1 receptionist in a 4-bed facility, and the mixed study site employed 1 medical doctor, 8 nurses, 3 theatre assistants, and 1 receptionist in a 6-bed facility.</p
Sensitivity analysis of device price on unit cost at mixed study site with 68% of circumcisions conducted using the PrePex device.
<p>Sensitivity analysis of device price on unit cost at mixed study site with 68% of circumcisions conducted using the PrePex device.</p
Cost drivers for unit cost of different implementation models.
<p>*84% surgery+16% PrePex.</p