Veishea Views Tomorrow

Highlighting the 1947 Veishea from the home economics angle will be the Home Economics Pre-Vue, sponsored and planned by the division\u27s Education Club. This all day open-house will be put on the second day of Veishea activities, which will be held this year on May 15, 16, and 17, under the slogan, Veishea View Tomorrow

Mitogen Activated Protein Kinase Phosphatase-1 Prevents the Development of Tactile Sensitivity In a Rodent Model of Neuropathic Pain

Neuropathic pain due to nerve injury is one of the most difficult types of pain to treat. Following peripheral nerve injury, neuronal and glial plastic changes contribute to central sensitization and perpetuation of mechanical hypersensitivity in rodents. The mitogen activated protein kinase (MAPK) family is pivotal in this spinal cord plasticity. MAPK phosphatases (MKPs) limit inflammatory processes by dephosphorylating MAPKs. For example, MKP-1 preferentially dephosphorylates p-p38. Since spinal p-p38 is pivotal for the development of chronic hypersensitivity in rodent models of pain, and p-p38 inhibitors have shown clinical potential in acute and chronic pain patients, we hypothesize that induction of spinal MKP-1 will prevent the development of peripheral nerve-injury-induced hypersensitivity and p-p38 overexpression. We cloned rat spinal cord MKP-1 and optimize MKP-1 cDNA in vitro using transfections to BV-2 cells. We observed that in vitro overexpression of MKP-1 blocked lipopolysaccharide-induced phosphorylation of p38 (and other MAPKs) as well as release of pro-algesic effectors (i.e., cytokines, chemokines, nitric oxide). Using this cDNA MKP-1 and a non-viral, in vivo nanoparticle transfection approach, we found that spinal cord overexpression of MKP-1 prevented development of peripheral nerve-injury-induced tactile hypersensitivity and reduced pro-inflammatory cytokines and chemokines and the phosphorylated form of p38

Primary care screening for peripheral arterial disease:a cross-sectional observational study

Background Early identification of peripheral arterial disease (PAD) and subsequent instigation of risk modification strategies could minimise disease progression and reduce overall risk of cardiovascular (CV) mortality. However, the feasibility and value of primary care PAD screening is uncertain. Aim This study (the PIPETTE study — Peripheral arterial disease In Primary carE: Targeted screening and subsequenT managEment) aimed to determine the value of a proposed primary care PAD screening strategy. Outcomes assessed were: prevalence of PAD and agreement of ankle– brachial index (ABI)-defined PAD (ABI ≤0.9) with QRISK®2-defined high CV risk (≥20). Design and setting A cross-sectional observational study was undertaken in a large general practice in Merthyr Tydfil, Wales. Method In total, 1101 individuals with ≥2 pre-identified CV risk factors but no known CV disease or diabetes were invited to participate. Participants underwent ABI measurement and QRISK2 assessment, and completed Edinburgh Claudication Questionnaires. Results A total of 368 people participated in the study (participation rate: 33%). Prevalence of PAD was 3% (n = 12). The number needed to screen (NNS) to detect one new case of PAD was 31. Refining the study population to those aged ≥50 years with a smoking history reduced the NNS to 14, while still identifying 100% of PAD cases. Of participants with PAD, 33% reported severe lifestyle-limiting symptoms of intermittent claudication that warranted subsequent endovascular intervention, yet had not previously presented to their GP. The QRISK2 score predicted high CV risk in 92% of participants with PAD. Conclusion The low PAD yield and the fact that QRISK2 was largely comparable to the ABI in predicting high CV risk suggests that routine PAD screening may be unwarranted. Instead, strategies to improve public awareness of PAD are neede

Packing and Hausdorff measures of stable trees

In this paper we discuss Hausdorff and packing measures of random continuous trees called stable trees. Stable trees form a specific class of L\'evy trees (introduced by Le Gall and Le Jan in 1998) that contains Aldous's continuum random tree (1991) which corresponds to the Brownian case. We provide results for the whole stable trees and for their level sets that are the sets of points situated at a given distance from the root. We first show that there is no exact packing measure for levels sets. We also prove that non-Brownian stable trees and their level sets have no exact Hausdorff measure with regularly varying gauge function, which continues previous results from a joint work with J-F Le Gall (2006).Comment: 40 page

The Iowa Homemaker vol.26, no.3

Keeping Up With Today, Joyce Edgar, page 2 Letter to Freshmen, A Senior, page 3 Manners – The You That Shows, Joan Kilty, page 4 Reflect Personalities in College Homes, Irene Meyer, page 5 Reason Your Writing, June Welch, page 6 Diaries Offer Activity Tips to Freshmen, Shirliann Forimann, page 7 What’s New in Home Economics, Marjorie Clampitt, page 8 Vicky Dresses for School, Breta Soldat, page 10 Why Freshmen Gain Weight, Nancy Baker, page 13 Iowa State Seniors Break into Print, Beverly Sieg, page 14 Homemakers Relax With Cookbooks, Helen Hochriem, page 17 Graduate Designs Greeting Cards, Carita Girton, page 19 Alums in the News, Goldie Rouse, page 2

Low-temperature heat capacities, thermophysical properties, optical spectra, and analysis of Schottky contributions to Pr(OH)3

From values of the heat capacity of microcrystalline Pr(OH)3 determined by precise adiabatic calorimetry from 15 to 350 K, the Schottky contribution associated with all but the lowest Stark level was resolved with the aid of a model of the lattice heat capacity based upon the molar volumes of the lanthanide trihydroxides. Visible and infrared absorption spectra were taken at approximately 95 K on microcrystalline mulls and the energy-level scheme and crystalline electric-field parameters evaluated. The Schottky contribution of all levels above the first excited state ([mu] = 3) was resolved by a new scheme for modeling the lattice contribution and compared with the same contribution deduced from the spectral results. Excellent accord was observed. These results together with magnetic results and the first excited Stark level were used to adjust the low-temperature heat capacities and thermodynamic functions so as to evaluate Cp/R, So/R, and - {Go - Ho(0)}/RT, at 298.15 K as 14.154, 15.84, and 7.766, respectively.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/23751/1/0000724.pd

The Iowa Homemaker vol.26, no.1

Keeping Up With Today, Joyce Edgar, page 2 Foods Graduate Supervises Hawaiian Canteen, Ann Koebel, page 3 First Introduction, Maryann Jones, page 4 Vicky Views Veishea, Charlene Stettler, page 6 She Cooks for the Clouds, Marlyn Cody, page 7 Look Toward Your Future, page 8 What’s New in Home Economics, Marjorie Clampitt, page 10 Pass the Rolls, Mary Ann Hakes, page 12 Modern Education Features Audio-Visual Aids, Nancy Baker, page 13 Hospital Kitchen Affords Experience, Maxine Burch, page 14 Across Alum Desks, Mary Neff, page 17 Roberts Hall Honors a Career of Service, Natalie Benda, page 18 Wardrobe Revivers for Spring, June Welch, page 19 Alums in the News, Goldie Rouse, page 2

Cannabinoid receptor type 2 activation induces a microglial anti-inflammatory phenotype and reduces migration via MKP induction and ERK dephosphorylation

<p>Abstract</p> <p>Background</p> <p>Cannabinoid receptor type 2 (CBR2) inhibits microglial reactivity through a molecular mechanism yet to be elucidated. We hypothesized that CBR2 activation induces an anti-inflammatory phenotype in microglia by inhibiting extracellular signal-regulated kinase (ERK) pathway, via mitogen-activated protein kinase-phosphatase (MKP) induction. MKPs regulate mitogen activated protein kinases, but their role in the modulation of microglial phenotype is not fully understood.</p> <p>Results</p> <p>JWH015 (a CBR2 agonist) increased MKP-1 and MKP-3 expression, which in turn reduced p-ERK1/2 in LPS-stimulated primary microglia. These effects resulted in a significant reduction of tumor necrosis factor-α (TNF) expression and microglial migration. We confirmed the causative link of these findings by using MKP inhibitors. We found that the selective inhibition of MKP-1 by Ro-31-8220 and PSI2106, did not affect p-ERK expression in LPS+JWH015-treated microglia. However, the inhibition of both MKP-1 and MKP-3 by triptolide induced an increase in p-ERK expression and in microglial migration using LPS+JWH015-treated microglia.</p> <p>Conclusion</p> <p>Our results uncover a cellular microglial pathway triggered by CBR2 activation. These data suggest that the reduction of pro-inflammatory factors and microglial migration via MKP-3 induction is part of the mechanism of action of CBR2 agonists. These findings may have clinical implications for further drug development.</p

The Iowa Homemaker vol.25, no.8

Poem, Lorraine Midlang, page 2 Letter to the Readers, New Talent Staff, page 3 Keeping Up With Today, New Talent Staff, page 4 Coeducational China, Marjorie Clampitt, page 5 Vacations Will Pay, Kay Williams, Sheron Hieronymus, page 6 Iowa State Students Prepare for Life, Breta Gath Soldat, page 8 Home Economics Builds for the Future, Mary Johnston, page 9 She Served in Navy Blue, Joyce Edgar, page 10 Trade Rollbooks for Hobbies, Mary Ellen Watt, page 11 What’s New in Home Economics, New Talent Staff, page 12 Welch Hall Weaves its History, June Welch, page 14 Coeds Share Treats From Home, Janet Ogilvie, page 15 Recommend Variety in Electives, Maryann Jones, page 16 Springtime Vicky Vamps and Revamps, Darlene Philip, page 18 Foresees Spring Fashion, Barbara Phillips, page 18 Alums in the News, Joyce Mongerson, page 19 Loan Funds Commemorative Friends of Students, Barbara Artus, page 21 Coeds Turn Camera Fans, Natalie Benda, page 22 Committee Achieves Needed Revisions, Goldie Rouse, page 23 Raccoon Meat is Delicious, Elizabeth Adams, page 2

The Iowa Homemaker vol.26, no.6

Extracurricular Activities Provide Training, Tony DeLay, page 2 Home Service Program for Young America, Doris Adams, page 3 The Home Economist in Business, Beth Bailey McLean, page 4 How to Become a Career Girl, Frances Kerekes, page 6 Clubs Combine as Future Homemakers of America, Barbara Bates, page 7 1947 Vicky Turns the Page of Fashion, Ann Fuhs, page 8 Christmas Lighting, Ann Rozeboom, page 9 Homemaking is a Challenging Career, Martha Coover, page 10 Good Professional Attitude, Mary Elizabeth Lush, page 11 Alum Head Product Testing Program, Lydia Cooley, page 12 Keeping Up With Today, Joyce Edgar, page 14 Festival Book Aids Party Planning, Luanne Madsen, page 1