Sustaining the Momentum: Archival Analysis of Enterprise Resource Planning Systems (2006–2012)

The domain of Enterprise Resource Planning (ERP) systems is an enduring paradigm for Information Systems (IS) researchers. The Enterprise System paradigm provides a rich environment to test fundamental concepts like system adoption, system use and system success, while acknowledging changes derived through longer system lifecycles and multiple user cohorts. On the other hand, ERP systems are in the centre of new contemporary radical changes in technologies on cloud computing, mobile platforms and big data. Moreover, ERP Systems provide the context for cross disciplinary research such as change management, knowledge management, project management and business process management research. This article provides a critique of 219 papers published on ERP Systems from 2006–2012, making observations of ERP research and make recommendations for future research directions

Who are the Operational Users of Enterprise Systems: Does One Size Fit All?

Suicide prevention is a major concern for railway operators internationally. This paper reports research in progress examining how information systems can facilitate passenger/organisational co-created value in terms of reducing the incidence of railway suicide. Thus, the objectives of this research are to: (1) explore and evaluate the effectiveness of using information systems interventions in a passenger railway servicescape, and (2) explore the relationship between these servicescape interventions and customer experience, and assess their impact on railway suicide prevention from a value co-creation perspective. While the focus of this research is preventing railway suicide, the information systems developed would also lend themselves to a wide range of additional railway security issues such as the detection and prevention of crime, terrorism, and potential misadventure incidents

Testing the Links from Fit to Effective Use to Impact: A Digital Hospital Case

The global health sector is undergoing rapid digital transformation. Because such transformations often fail to meet expectations, researchers have begun studying the full chain from implementation to outcomes to learn what improvements are needed. Recent studies suggest that it is especially important to learn what ‘effective use’ of new systems involve, because effective use is the lynchpin between a system and its benefits. A key challenge, however, is operationalizing effective use. In this paper, we compare two approaches: theory-driven, operationalizing effective use using the ‘theory of effective use’, and context-driven, operationalizing it in terms of the workarounds users devise to achieve their goals. We compare these approaches using survey data from a multi-hospital digital transformation. The results support the theory-driven approach, while offering useful insights on workarounds

The conceptualization and investigation of user capital and its impact on effective use and information systems success

The use and success of Information Systems (IS) is becoming increasingly reliant on users. Therefore, this study sought to develop and test a construct around the notion of User Capital, which this research defines as the attributes possessed by an individual that enable them to use an IS to perform tasks. User Capital was formed by the dimensions of self-regulation, competence, mastery orientation, and attitude. To test the construct a largely quantitative field study approach was adopted. User Capital was found to be a significant driver of effective use and a key construct in the examination of IS success

The dynamics of organizational culture: the case of culture work in a digital hospital

With the increasing infusion of information systems through organizations, a dynamic understanding of the relationship between cultural values and artifacts is critical. This paper responds to calls to explore organizational culture from a dynamic view rather than the traditional static approach. We performed a case study using grounded theory principles of a digital transformation of a large, acute-care hospital in Australia. Our analysis reveals new insights into the dynamic relationship between the values of the new system (artifact) and the values of the organization, referred to as retroactive and proactive realization respectively. We extend past research by developing a process model that reveals how different types of culture work - the actions and doings through which culture is created, maintained, and disrupted - are invoked during realization processes. This research deepens our understanding of the realization process and the alignment literature with implications for research and practice

Revealing the Root Causes of Digital Health Data Quality Issues: A Qualitative Investigation of the Odigos Framework

Digital health data quality is a critical concern in the healthcare industry, jeopardizing the secondary use of data for revolutionizing population health, and hindering patient care and organizational outcomes. Limited published evidence exists for explaining why these data quality issues emerge. The Odigos framework is a notable exception asserting that data quality issues emerge from three worlds: material world (e.g., technology artifact), personal world (e.g., technology users/use), and social world (e.g., organizations/ institutions) but has yet to systematically unpack the elements within these worlds. Through deductive and inductive analysis of interview data from a case study of the Emergency Department of Australia’s first large digital hospital, we apply and extend the Odigos framework by identifying elements emanating from the three worlds and their interrelationships as root causes of data quality issues. These elements can then be used by hospitals to develop strategies to proactively improve their digital health data quality

Digital Health Data Imperfection Patterns and Their Manifestations in an Australian Digital Hospital

Whilst digital health data provides great benefits for improved and effective patient care and organisational outcomes, the quality of digital health data can sometimes be a significant issue. Healthcare providers are known to spend a significant amount of time on assessing and cleaning data. To address this situation, this paper presents six Digital Health Data Imperfection Patterns that provide insight into data quality issues of digital health data, their root causes, their impact, and how these can be detected. Using the CRISP-DM methodology, we demonstrate the utility and pervasiveness of the patterns at the emergency department of Australia's major tertiary digital hospital. The pattern collection can be used by health providers to identify and prevent key digital health data quality issues contributing to reliable insights for clinical decision making and patient care delivery. The patterns also provide a solid foundation for future research in digital health through its identification of key data quality issues, root causes, detection techniques, and terminology

Effect of Hydrocortisone on Mortality and Organ Support in Patients With Severe COVID-19: The REMAP-CAP COVID-19 Corticosteroid Domain Randomized Clinical Trial.

Importance: Evidence regarding corticosteroid use for severe coronavirus disease 2019 (COVID-19) is limited. Objective: To determine whether hydrocortisone improves outcome for patients with severe COVID-19. Design, Setting, and Participants: An ongoing adaptive platform trial testing multiple interventions within multiple therapeutic domains, for example, antiviral agents, corticosteroids, or immunoglobulin. Between March 9 and June 17, 2020, 614 adult patients with suspected or confirmed COVID-19 were enrolled and randomized within at least 1 domain following admission to an intensive care unit (ICU) for respiratory or cardiovascular organ support at 121 sites in 8 countries. Of these, 403 were randomized to open-label interventions within the corticosteroid domain. The domain was halted after results from another trial were released. Follow-up ended August 12, 2020. Interventions: The corticosteroid domain randomized participants to a fixed 7-day course of intravenous hydrocortisone (50 mg or 100 mg every 6 hours) (n = 143), a shock-dependent course (50 mg every 6 hours when shock was clinically evident) (n = 152), or no hydrocortisone (n = 108). Main Outcomes and Measures: The primary end point was organ support-free days (days alive and free of ICU-based respiratory or cardiovascular support) within 21 days, where patients who died were assigned -1 day. The primary analysis was a bayesian cumulative logistic model that included all patients enrolled with severe COVID-19, adjusting for age, sex, site, region, time, assignment to interventions within other domains, and domain and intervention eligibility. Superiority was defined as the posterior probability of an odds ratio greater than 1 (threshold for trial conclusion of superiority >99%). Results: After excluding 19 participants who withdrew consent, there were 384 patients (mean age, 60 years; 29% female) randomized to the fixed-dose (n = 137), shock-dependent (n = 146), and no (n = 101) hydrocortisone groups; 379 (99%) completed the study and were included in the analysis. The mean age for the 3 groups ranged between 59.5 and 60.4 years; most patients were male (range, 70.6%-71.5%); mean body mass index ranged between 29.7 and 30.9; and patients receiving mechanical ventilation ranged between 50.0% and 63.5%. For the fixed-dose, shock-dependent, and no hydrocortisone groups, respectively, the median organ support-free days were 0 (IQR, -1 to 15), 0 (IQR, -1 to 13), and 0 (-1 to 11) days (composed of 30%, 26%, and 33% mortality rates and 11.5, 9.5, and 6 median organ support-free days among survivors). The median adjusted odds ratio and bayesian probability of superiority were 1.43 (95% credible interval, 0.91-2.27) and 93% for fixed-dose hydrocortisone, respectively, and were 1.22 (95% credible interval, 0.76-1.94) and 80% for shock-dependent hydrocortisone compared with no hydrocortisone. Serious adverse events were reported in 4 (3%), 5 (3%), and 1 (1%) patients in the fixed-dose, shock-dependent, and no hydrocortisone groups, respectively. Conclusions and Relevance: Among patients with severe COVID-19, treatment with a 7-day fixed-dose course of hydrocortisone or shock-dependent dosing of hydrocortisone, compared with no hydrocortisone, resulted in 93% and 80% probabilities of superiority with regard to the odds of improvement in organ support-free days within 21 days. However, the trial was stopped early and no treatment strategy met prespecified criteria for statistical superiority, precluding definitive conclusions. Trial Registration: ClinicalTrials.gov Identifier: NCT02735707

Effect of angiotensin-converting enzyme inhibitor and angiotensin receptor blocker initiation on organ support-free days in patients hospitalized with COVID-19

IMPORTANCE Overactivation of the renin-angiotensin system (RAS) may contribute to poor clinical outcomes in patients with COVID-19. Objective To determine whether angiotensin-converting enzyme (ACE) inhibitor or angiotensin receptor blocker (ARB) initiation improves outcomes in patients hospitalized for COVID-19. DESIGN, SETTING, AND PARTICIPANTS In an ongoing, adaptive platform randomized clinical trial, 721 critically ill and 58 non–critically ill hospitalized adults were randomized to receive an RAS inhibitor or control between March 16, 2021, and February 25, 2022, at 69 sites in 7 countries (final follow-up on June 1, 2022). INTERVENTIONS Patients were randomized to receive open-label initiation of an ACE inhibitor (n = 257), ARB (n = 248), ARB in combination with DMX-200 (a chemokine receptor-2 inhibitor; n = 10), or no RAS inhibitor (control; n = 264) for up to 10 days. MAIN OUTCOMES AND MEASURES The primary outcome was organ support–free days, a composite of hospital survival and days alive without cardiovascular or respiratory organ support through 21 days. The primary analysis was a bayesian cumulative logistic model. Odds ratios (ORs) greater than 1 represent improved outcomes. RESULTS On February 25, 2022, enrollment was discontinued due to safety concerns. Among 679 critically ill patients with available primary outcome data, the median age was 56 years and 239 participants (35.2%) were women. Median (IQR) organ support–free days among critically ill patients was 10 (–1 to 16) in the ACE inhibitor group (n = 231), 8 (–1 to 17) in the ARB group (n = 217), and 12 (0 to 17) in the control group (n = 231) (median adjusted odds ratios of 0.77 [95% bayesian credible interval, 0.58-1.06] for improvement for ACE inhibitor and 0.76 [95% credible interval, 0.56-1.05] for ARB compared with control). The posterior probabilities that ACE inhibitors and ARBs worsened organ support–free days compared with control were 94.9% and 95.4%, respectively. Hospital survival occurred in 166 of 231 critically ill participants (71.9%) in the ACE inhibitor group, 152 of 217 (70.0%) in the ARB group, and 182 of 231 (78.8%) in the control group (posterior probabilities that ACE inhibitor and ARB worsened hospital survival compared with control were 95.3% and 98.1%, respectively). CONCLUSIONS AND RELEVANCE In this trial, among critically ill adults with COVID-19, initiation of an ACE inhibitor or ARB did not improve, and likely worsened, clinical outcomes. TRIAL REGISTRATION ClinicalTrials.gov Identifier: NCT0273570

Archival analysis of service desk research: New perspectives on design and delivery

ur analysis of service desk studies shows the extent to which researchers have neglected important aspects of service desk design and delivery. The observations are made through an archival analysis of 58 peer reviewed publications in top tier outlets. Our analysis led to the development of a generic framework which identified three themes in service desk design: (1) user groups, (2) support models, and; (3) technology types And two themes in service desk delivery: (1) direction of delivery, and; (2) executive support level. This paper makes a twofold contribution to service desk research. First, it provides an understanding of service desk functions and the challenges faced by organisations in delivering those functions. Second, it identifies established and emerging areas in the service desk field. This archival analysis is the first attempt to systematically analyse the service desk literature