Edukasi Strategi Pendampingan Belajar dari Rumah untuk Membangun Situasi Belajar Kondusif di Lingkungan Candi Baru, Gianyar

Since December 2019, the world has been shocked by the Covid-19 virus which can be transmitted through small droplets that come out when sneezing from the nose or mouth of people who are infected with the virus. To break the chain of spreading this virus, the government enforces a rule that all activities are carried out from home, including learning activities. Through community service activities carried out by this author, it aims to determine the effectiveness of online learning mentoring education for parents whose children are following the online learning process from home, so as to reduce the difficulties of parents when accompanying their children to learn from home. The target partners of this service are several communities whose children study online at home in the Candi Baru neighborhood, Gianyar. The method used in this study is the PAR research method, which is a method that emphasizes the participation and collaboration of various parties in managing a research. This research shows that the provision of online learning mentoring education can increase parents' knowledge and understanding of online learning. &nbsp

Cara memasarkan produk UMKM pada masa COVID-19 melalui media sosial

Melemahnya ekonomi karena adanya pandemi COVID-19 dapat berdampak langsung terhadap UMKM Roti yang ada di Desa Padangsambian, Kecamatan Denpasar Barat. Hal tersebut menyebabkan permintaan dan pendapatan berkurang. Solusi yang dapat dilakukan untuk mengatasi permasalahan tersebut dengan memberikan edukasi dan pelatihan terkait dengan penggunaan dan pembuatan akun digital marketingsebagai alat untuk memasarkan produk UKM Roti di Desa Padangsambian. Edukasi yang diberikan berupa pelatihan mengenai cara memasarkan produk di media social, e-commerce, dan website dengan tepat dan benar. Program lain yang diberikan yaitu dengan asistensi pembuatan akun e-commerce dan digital marketingyang lainnya yang akan digunakan untuk promosi.Platform yang dipilih yaitu media yang memiliki jejaring pengguna besar di Indonesia, yaitu Facebook, Intagram, dan Shopee Food. Metode yang digunakan dalam kegiatan ini adalah pelatihan dan pendampingan. Hasil dari kegiatan ini adalah  terbentuknya akun digital marketingseperti Facebook, Instagram, dan juga Shopee Food yang digunakan untuk mempromosikan hasil produksi dari UMKM Roti sehingga dapat meningkatkan pendapatan penjualan hasil produksi, hasil pengabdian ini sangat bermanfaat bagi UMKM Roti untuk mempertahankan usahanya di tengah pandemi COVID-19 saat ini. Sebagai tindak lanjut, diharapkan pemerintah desa setempat bekerja sama dengan pihak ketiga memberikan pelatihan pembuatan konten marketing, sehingga akun yang telah dibuat dapat dimaksimalkan untuk memasarkan produk UKM Roti

Immersive Experience in the Metaverse: Implications for Tourism and Business

By providing immersive and interactive experiences, the metaverse has been changing how tourists spend their vacation. It also presents new business challenges, such as gaming, marketing, education, and smart city industries. This research explores the opportunities and challenges presented by the metaverse in the tourism and business industries. This research also discusses the metaverse implications that can transform people's experience and consumption when traveling and consuming. A comprehensive literature review was conducted to explore the implications of the metaverse for the tourism and business industries. This study's findings reveal several examples of applying the metaverse and its implications. In addition, this study also discovered that the emergence of the metaverse significantly impacts the tourism and business sectors. In practice, the review findings make tourism and business stakeholders aware of the potential of this immersive technology. Tourism providers and business leaders might consider using the metaverse to promote tourism destination and their businesses and develop a system that can maximize the benefits of this immersive technology

BRAF mutation-specific promoter methylation of FOX genes in colorectal cancer

Background: Cancer-specific hypermethylation of (promoter) CpG islands is common during the tumorigenesis of colon cancer. Although associations between certain genetic aberrations, such as BRAF mutation and microsatellite instability, and the CpG island methylator phenotype (CIMP), have been found, the mechanisms by which these associations are established are still unclear. We studied genome-wide DNA methylation differences between

The homeobox gene MEIS1 is methylated in BRAFp.V600E mutated colon tumors

Development of colorectal cancer (CRC) can occur both via gene mutations in tumor suppressor genes and oncogenes, as well as via epigenetic changes, including DNA methylation. Site-specific methylation in CRC regulates expression of tumor-associated genes. Right-sided colon tumors more frequently have BRAFp.V600E mutations and have higher methylation grades when compared to left-sided malignancies. The aim of this study was to identify DNA methylation changes associated with BRAFp.V600E mutation status. We performed methylation profiling of colon tumor DNA, isolated from frozen sections enriched for epithelial cells by macro-dissection, and from paired healthy tissue. Single gene analyses comparing BRAFp.V600E with BRAF wild type revealed MEIS1 as the most significant differentially methylated gene (log2 fold change: 0.89, false discovery rate-adjusted P-value 2.8*10-9). This finding was validated by methylation-specific PCR that was concordant with the microarray data. Additionally, validation in an independent cohort (n=228) showed a significant association between BRAF p.V600E and MEIS1 methylation (OR: 13.0, 95% CI: 5.2 - 33.0, P<0.0001). MEIS1 methylation was associated with decreased MEIS1 gene expression in both patient samples and CRC cell lines. The same was true for gene expression of a truncated form of MEIS1, MEIS1D27, which misses exon 8 and has a proposed tumor suppression function. To trace the origin of MEIS1 promoter methylation, 14 colorectal tumors were flow-sorted. Four out of eight BRAFp.V600E tumor epithelial fractions (50%) showed MEIS1 promoter methylation, as well as three out of eight BRAFp.V600E stromal fractions (38%). Only one out of six BRAF wild type showed MEIS1 promoter methylation in both the epithelial tumor and stromal fractions (17%). In conclusion, BRAFp.V600E colon tumors showed significant MEIS1 promoter methylation, which was associated with decreased MEIS1 gene expression. Copyright

Nonlinear Time Series Analysis of Sunspot Data

This paper deals with the analysis of sunspot number time series using the Hurst exponent. We use the rescaled range (R/S) analysis to estimate the Hurst exponent for 259-year and 11360-year sunspot data. The results show a varying degree of persistence over shorter and longer time scales corresponding to distinct values of the Hurst exponent. We explain the presence of these multiple Hurst exponents by their resemblance to the deterministic chaotic attractors having multiple centers of rotation.Comment: 10 pages, 6 figures, accepted for publication in Solar Physics, journal style corrections done in this versio

Ecological Complex Systems

Main aim of this topical issue is to report recent advances in noisy nonequilibrium processes useful to describe the dynamics of ecological systems and to address the mechanisms of spatio-temporal pattern formation in ecology both from the experimental and theoretical points of view. This is in order to understand the dynamical behaviour of ecological complex systems through the interplay between nonlinearity, noise, random and periodic environmental interactions. Discovering the microscopic rules and the local interactions which lead to the emergence of specific global patterns or global dynamical behaviour and the noises role in the nonlinear dynamics is an important, key aspect to understand and then to model ecological complex systems.Comment: 13 pages, Editorial of a topical issue on Ecological Complex System to appear in EPJ B, Vol. 65 (2008

Early treatment versus expectative management of patent ductus arteriosus in preterm infants

_Background:_ Much controversy exists about the optimal management of a patent ductus arteriosus (PDA) in preterm infants, especially in those born at a gestational age (GA) less than 28weeks. No causal relationship has been proven between a (haemodynamically significant) PDA and neonatal complications related to pulmonary hyperperfusion and/or systemic hypoperfusion. Although studies show conflicting results, a common understanding is that medical or surgical treatment of a PDA does not seem to reduce the risk of major neonatal morbidities and mortality. As the PDA might have closed spontaneously, treated children are potentially exposed to iatrogenic adverse effects. A conservative approach is gaining interest worldwide, although convincing evidence to support its use is lacking. _Methods:_ This multicentre, randomised, non-inferiority trial is conducted in neonatal intensive care units. The study population consists of preterm infants (GA1.5mm. Early treatment (between 24 and 72h postnatal age) with the cyclooxygenase inhibitor(COXi) ibuprofen (IBU) is compared with an expectative management (no intervention intended to close a PDA). The primary outcome is the composite of mortality, and/or necrotising enterocolitis (NEC) Bell stage ≥ IIa, and/or bronchopulmonary dysplasia (BPD) defined as the need for supplemental oxygen, all at a postmenstrual age (PMA) of 36weeks. Secondary outcome parameters are short term sequelae of cardiovascular failure, comorbidity and adverse events assessed during hospitalization and long-term neurodevelopmental outcome assessed at a corrected age of 2 years. Consequences regarding health economics are evaluated by cost effectiveness analysis and budget impact analysis. _Discussion:_ As a conservative approach is gaining interest, we investigate whether in preterm infants, born at a GA less than 28weeks, with a PDA an expectative management is non-inferior to early treatment with IBU regarding to the composite outcome of mortality and/or NEC and/or BPD at a PMA of 36weeks