Metabolism of Human Diseases: Organ Physiology and Pathophysiology

Metabolism of Human Diseases is directed at advanced students, doctors, and scientists from all categories of life sciences and medicine (e.g., biochemists, biologists, physiologists, pharmacologists, pharmacists, toxicologists, and physicians) with an interest in the metabolism and molecular mechanisms of human diseases, irrespective of their specialization. The book is divided into different parts, each related to a human organ or tissue. Each part begins with an overview chapter presenting the a natomic and physiological properties of the organ or tissue in question relevant for the subsequent disease chapters of the section. The overview introduces organ- or tissue-speci? c metabolism and signaling pathways as well as intra- and inter-organ communication (i.e., “inside-in,” inside-out,” and “outside-in” signaling). The disease chapters discuss pathomechanisms of the diseases with emphasis on metabolic alterations and affected signaling pathways. In addition, they brie? y introduce major treatments currently in use and in clinical trials as well as their in? uence on the patient’s metabolism