9 research outputs found
<strong>EFFECTS AND REVERSIBILITY OF ANDROGENIC EXPOSURE IN </strong><strong>ZEBRAFISH</strong><em> (Danio rerio)</em><em> </em>
A study on the Effects of the Androgenic Steroid Trenbolone on Sexual Development in Zebrafish (<em>Danio rerio</em>) and the Possible Revesibility of the Effects
17β-estradiol causes abnormal development in embryos of the viviparous eelpout
Elevated frequencies of malformations
among the offspring of Baltic
eelpout (Zoarces viviparus) have been
observed in aquatic environments receiving high anthropogenic input
suggesting that manmade chemicals could be the causative agent. However,
causal links between exposure to chemicals and abnormal development
have never been confirmed in laboratory experiments. The purpose of
this study was to investigate if exposure to 17β-estradiol (E2)
causes abnormal development in larvae of the viviparous eelpout. Wild
female eelpout were collected immediately after fertilization and
exposed to E2 concentrations ranging from 5.7 to 133 ng L<sup>–1</sup> for 6 weeks in a flow through test system. The experiment shows
that E2 concentrations of 53.6 and 133 ng L<sup>–1</sup> cause
severe abnormal development among eelpout embryos. Reduced amount
of ovarian fluid and increased weight of the ovarian sac indicate
disturbance of ovarian function. Female plasma concentrations of E2
and vitellogenin increase in a monotonic concentration–response
relationship with significant induction in the low concentration range.
Our findings support the plausibility that the abnormal development
among eelpout embryos encountered in monitoring programs may actually
be caused by exposure to chemicals in the environment