9 research outputs found
The Facile Synthesis of N-Aryl Isoxazolones as DNA Intercalators Under Solvent-free Conditions Using Microwave Irradiation
Get PDFThe reaction of chloroheterocycles with some isoxazolones under microwave irradiation and under solvent-free conditions to give the corresponding mono isoxazolinyl derivatives is reported. The main advantages of this method are: (i) elimination of the nitrogen gas (N2), (ii) solvent-free conditions, (iii) microwave irradiation, (iv) avoiding the use of silica gel for purification of the products, and (v) higher and shorter reaction times. These compounds have potential applications as DNA intercalators.Keywords: Isoxazolones, N-aryl isoxazolones, solvent-free, 2-chlorobenzoxazole, 2-chlorobenzothiazol
Synthesis of new N-Benzoxazole and N-Benzothiazole derivatives of 3-(4-Substituted- phenyl)aminoisoxazol-5(2H)-ones and comparison of their base induced rearrangement
No full text3-Arylaminoisoxazol-5(2H)-ones, substituted on nitrogen with benzoxazole and benzothiazole groups react with triethylamine in ethanol under reflux to afford the corresponding indole and imidazobenzothiazole derivatives, respectively
Synthesis of new N-Benzoxazole and N-Benzothiazole derivatives of 3-(4-Substituted- phenyl)aminoisoxazol-5(2H)-ones and comparison of their base induced rearrangement
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The synthesis of potential DNA intercalators. Part 3. Triazanaphthalene, tetraaza-anthracenes and phenanthrenes from isoxazolones
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