12 research outputs found
Changes in mediators of inflammation and pro-thrombosis after 12 months of dietary modification in adults with metabolic syndrome.
Objective: This study evaluated the effects of a 12-month dietary
modification on indices of inflammation and pro-thrombosis in adults
with metabolic syndrome (MS). Materials and methods: This longitudinal
study involved 252 adults with MS recruited from the Bodija market,
Ibadan and its environs. Participants were placed on 20%, 30% and 50%
calories obtained from protein, total fat and carbohydrate respectively
and were followed up monthly for 12 months. Anthropometry and blood
pressure were measured using standard methods. Fasting plasma glucose
(FPG), total cholesterol (TC), triglycerides (TG), high density
lipoprotein-cholesterol (HDL-C), fibrinogen, plasminogen activator
inhibitor-1 (PAI-1)], interleukin-6 (IL-6) and interleukin-10 (IL-10)
were measured using spectrophotometric methods and ELISA as
appropriate. Data was analysed using ANCOVA, Student\u2019s t-test,
Mann-Whitney U and Wilcoxon signed-rank tests. P-values less than 0.05
were considered significant. Results: After 6 months of dietary
modification, there was a significant reduction in waist circumference
(WC), while the levels of HDL-C, fibrinogen and PAI-1 were
significantly increased when compared with the corresponding baseline
values. However, WC and fibrinogen reduced significantly, while HDL-C
and IL-10 significantly increased after 12 months of dietary
modification as compared with the respective baseline values.
Conclusion: Long-term regular dietary modification may be beneficial in
ameliorating inflammation and pro-thrombosis in metabolic syndrome