935 research outputs found
Economics of tandem mass spectrometry screening of neonatal inherited disorders
Objectives: The aim of this study was to evaluate the cost-effectiveness of neonatal screening for phenylketonuria (PKU) and medium-chain acyl-coA dehydrogenase (MCAD) deficiency using tandem mass spectrometry (tandem MS).
Methods: A systematic review of clinical efficacy evidence and cost-effectiveness modeling of screening in newborn infants within a UK National Health Service perspective was performed. Marginal costs, life-years gained, and cost-effectiveness acceptability curves are presented.
Results: Substituting the use of tandem MS for existing technologies for the screening of PKU increases costs with no increase in health outcomes. However, the addition of screening for MCAD deficiency as part of a neonatal screening program for PKU using tandem MS, with an operational range of 50,000 to 60,000 specimens per system per year, would result in a mean incremental cost of −£17,298 (−£129,174, £66,434) for each cohort of 100,000 neonates screened. This cost saving is associated with a mean incremental gain of 57.3 (28.0, 91.4) life-years.
Conclusions: Cost-effectiveness analysis using economic modeling indicates that substituting the use of tandem MS for existing technologies for the screening of PKU alone is not economically justified. However, the addition of screening for MCAD deficiency as part of a neonatal screening program for PKU using tandem MS would be economically attractive
Absolute continuity and spectral concentration for slowly decaying potentials
We consider the spectral function for the
Sturm-Liouville equation on with the
boundary condition and where has slow decay
as . We develop our previous methods of locating spectral
concentration for with rapid exponential decay (JCAM 81 (1997) 333-348) to
deal with the new theoretical and computational complexities which arise for
slow decay
Extensions of a New Algorithm for the Numerical Solution of Linear Differential Systems on an Infinite Interval
This paper is part of a series of papers in which the asymptotic theory and
appropriate symbolic computer code are developed to compute the asymptotic
expansion of the solution of an n-th order ordinary differential equation. The
paper examines the situation when the matrix that appears in the Levinson
expansion has a double eigenvalue. Application is made to a fourth-order ODE
with known special function solution
Newborn screening using tandem mass spectrometry: A systematic review
Objectives: To evaluate the evidence for the clinical effectiveness of neonatal screening for phenylketonuria (PKU) and medium-chain acyl-coA dehydrogenase (MCAD) deficiency using tandem mass spectrometry (tandem MS).
Study design: Systematic review of published research.
Data sources: Studies were identified by searching 12 electronic bibliographic databases; conference proceedings and experts consulted.
Results: Six studies were selected for inclusion in the review. The evidence of neonatal screening for PKU and MCAD deficiency using tandem MS was primarily from observational data of large-scale prospective newborn screening programmes and systematic screening studies from Australia, Germany and the USA. Tandem MS based newborn screening of dried blood spots for PKU and/or MCAD deficiency was shown to be highly sensitive (>93.220%) and highly specific (>99.971%). The false positive rate for PKU screening was less than 0.046% and for MCAD deficiency the false positive rate was less than 0.023%. The positive predictive values ranged from 20 to 32% and 19 to 100%, respectively.
Conclusions: This review suggests that neonatal screening of dried blood spots using a single analytical technique (tandem MS) is highly sensitive and specific for detecting cases of PKU and MCAD deficiency, and provides a basis for modelling of the clinical benefits and potential costeffectiveness
The new physics of non-equilibrium condensates: insights from classical dynamics
We discuss the dynamics of classical Dicke-type models, aiming to clarify the
mechanisms by which coherent states could develop in potentially
non-equilibrium systems such as semiconductor microcavities. We present
simulations of an undamped model which show spontaneous coherent states with
persistent oscillations in the magnitude of the order parameter. These states
are generalisations of superradiant ringing to the case of inhomogeneous
broadening. They correspond to the persistent gap oscillations proposed in
fermionic atomic condensates, and arise from a variety of initial conditions.
We show that introducing randomness into the couplings can suppress the
oscillations, leading to a limiting dynamics with a time-independent order
parameter. This demonstrates that non-equilibrium generalisations of polariton
condensates can be created even without dissipation. We explain the dynamical
origins of the coherence in terms of instabilities of the normal state, and
consider how it can additionally develop through scattering and dissipation.Comment: 10 pages, 4 figures, submitted for a special issue of J. Phys.:
Condensed Matter on "Optical coherence and collective phenomena in
nanostructures". v2: added discussion of links to exact solution
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