Mars climate engineering using orbiting solar reflectors

The manned mission is seen as a first step towards a Mars surface exploration base-station and, later, establishing permanent settlement. The location and use of Mars's natural resources is vital to enable cost-effective long-duration human exploration and exploitation missions as well as subsequent human colonization. Planet resources include various crust-lodged materials, a low-pressure natural atmosphere, assorted forms of utilizable energy, lower gravity than Earth's, and ground placement advantages relative to human operability and living standards. Power resources may include using solar and wind energy, importation of nuclear reactors and the harvesting of geothermal potential. In fact, a new branch of human civilization could be established permanently on Mars in the next century. But, meantime, an inventory and proper social assessment of Mars's prospective energy and material resources is required. This book investigates the possibilities and limitations of various systems supplying manned bases on Mars with energy and other vital resources. The book collects together recent proposals and innovative options and solutions. It is a useful source of condensed information for specialists involved in current and impending Mars-related activities and a good starting point for young researchers

Viability analysis and apoptosis induction of breast cancer cells in a microfluidic device: effect of cytostatic drugs

Breast cancer is the leading cause of cancer deaths among non-smoking women worldwide. At the moment the treatment regime is such that patients receive different chemotherapeutic and/or hormonal treatments dependent on the hormone receptor status, the menopausal status and age. However, in vitro sensitivity testing of tumor biopsies could rationalize and improve the choice of chemo- and hormone therapy. Lab-on-a-Chip devices, using microfluidic techniques, make detailed cellular analysis possible using fewer cells, enabling working with a patients’ own cells and performing chemo- and hormone sensitivity testing in an ex vivo setting. This article describes the development of two microfluidic devices made in poly(dimethylsiloxane) (PDMS) to validate the cell culture properties and analyze the chemosensitivity of MCF-7 cells (estrogen receptor positive human breast cancer cells) in response to the drug staurosporine (SSP). In both cases, cell viability was assessed using the life-stain Calcein-AM (CAAM) and the death dye propidium iodide (PI). MCF-7 cells could be statically cultured for up to 7 days in the microfluidic chip. A 30 min flow with SSP and a subsequent 24 h static incubation in the incubator induced apoptosis in MCF-7 cells, as shown by a disappearance of the aggregate-like morphology, a decrease in CAAM staining and an increase in PI staining. This work provides valuable leads to develop a microfluidic chip to test the chemosensitivity of tumor cells in response to therapeutics and in this way improve cancer treatment towards personalized medicine

The Fresnel interferometric imager

International audienceThe Fresnel interferometric imager is a new kind of high angular resolution space instrument for the UV domain, and the related astrophysical targets. This optical concept is meant to allow larger and lighter apertures in space than solid state optics. It yields high dynamic range images and same resolution as that of a solid aperture of the same size. The long focal lengths of the Fresnel imager (a few kilometers) require operation by two-vessel formation flying in space. The first vessel holds a large and thin opaque foil punched with thousands of holes: the interferometric array, the second vessel holds the focal instrumentation. This Fresnel imager has been designed for mapping high contrast stellar environments: dust disks, close companions and (we hope) exoplanets. Compact objects such as large stellar photospheres may be imaged with array sizes of a few meters in the UV. Larger and more complex fields can also be imaged, although with a lesser dynamic range, such as small fields on galactic clouds or extragalactic fields, or in an other domain: small solar system bodies. We present the first images obtained on artificial sources with an 8 cm laboratory testbed array having 26680 apertures, the measured dynamic range of these images and their diffraction limited angular resolution. A 3 m class probatory space mission will be studied and follow a validation path, It has been submitted as a proposal to the ESA Cosmic Vision program

Teachers’ Assessment of Physical Aggression With the Preschool Behavior Questionnaire: A Multitrait-Multimethod Evaluation of Convergent and Discriminant Validity

status: publishe