Autoimmunization of Ewes Against Pregnancy-associated Glycoproteins Does Not Interfere with the Establishment and Maintenance of Pregnancy

doi:10.1017/S1751731109004145Pregnancy-associated glycoproteins (PAGs) are a large grouping of placental proteins that belong to the aspartic peptidase gene family. Although useful to detect pregnancy in ruminant species, the function of these molecules is unclear. Several PAGs expressed by trophoblast binucleate cells can enter the maternal circulation, suggesting that they could have a systemic role in altering maternal physiology. The objective of this work was to examine whether these circulating placental antigens were important in pregnancy by actively immunizing ewes against them. PAGs were purified by pepstatin-affinity chromatography and conjugated to the immunogenic protein, keyhole limpet hemocyanin (KLH). Ewes were immunized with PAG-KLH conjugate (n522) or with KLH alone (n59), and bred to intact rams. Blood samples, collected on Day 0 (day of estrus), Day 10, Days 15 to 25 and weekly throughout pregnancy, were analyzed for PAG by an ELISA. On Day 30, pregnancy was confirmed by ultrasound. Ewes immunized against PAG-KLH produced a range of reactive anti-PAG titers, whereas all immunized ewes had high anti-KLH immunoreactivity. PAGs became detectable in the anti-KLH (control) ewes at Day 21.662.2 of pregnancy. Those ewes immunized against PAGs (n57), that had very low immunoreactivity toward PAGs, had measurable PAG by Day 22.961.3, and their PAG serum profiles throughout pregnancy did not differ from the controls. Those exhibiting moderate to high anti-PAG immunoreactivity (n515), had significantly lower PAG concentrations than controls, with antigen not becoming detectable until Day 48.1615.6. The decrease in circulating PAG in the immunized animals did not correlate with changes in pregnancy rates, lamb number or lamb birth weight. These results suggest that while PAGs may play a role in maintaining pregnancy, their major contribution is likely to be at the fetal-maternal interface. Their actions at extra-placental sites are presumably of more secondary importance.This work was supported by NIH Grant HD21896 and the Animal Reproductive Biology Group of the University of Missouri Food for the 21st Century Program

The Use of a Kinetic Therapy Rotational Bed in Pediatric Acute Respiratory Distress Syndrome: A Case Series

Patients with acute respiratory distress syndrome (ARDS) commonly have dependent atelectasis and heterogeneous lung disease. Due to the heterogenous lung volumes seen, the application of positive end expiratory pressure (PEEP) can have both beneficial and deleterious effects. Alternating supine and prone positioning may be beneficial in ARDS by providing more homogenous distribution of PEEP and decreasing intrapulmonary shunt. In pediatrics, the pediatric acute lung injury and consensus conference (PALICC) recommended to consider it in severe pediatric ARDS (PARDS). Manually prone positioning patients can be burdensome in larger patients. In adults, the use of rotational beds has eased care of these patients. There is little published data about rotational bed therapy in children. Therefore, we sought to describe the use of a rotational bed in children with PARDS. We performed a retrospective case series of children who utilized a rotational bed as an adjunctive therapy for their PARDS. Patient data were collected and analyzed. Descriptive statistical analyses were performed and reported. Oxygenation indices (OI) pre- and post-prone positioning were analyzed. Twelve patients with PARDS were treated with a rotational bed with minimal adverse events. There were no complications noted. Three patients had malfunctioning of their arterial line while on the rotational bed. Oxygenation indices improved over time in 11 of the 12 patients included in the study while on the rotational bed. Rotational beds can be safely utilized in pediatric patients. In larger children with PARDS, where it may be more difficult to perform a manual prone position, use of a rotational bed can be considered a safe alternative

The Vehicle, Spring 1988

Contents CitizenCraig Titleypage 3 Justice DistributionAngie Geraldpage 4 Letter from My MotherDan Von Holtenpage 6 The Fool and His LadyRodger Patiencepage 7 What Big IsBob Zordanipage 8 Blind ArchitectureJim Reedpage 9 Ah, What a Funny Thing These EyesCraig Titleypage 10 FarmingPatrick Peterspage 11 The CowSteven M. Beamerpage 13 The Enigma of My ExistenceAngie Kathpage 14 Neon TeethMichael Salempage 15 Zombie PoseidonMichael Salempage 16 From: Letters from the Linder BuildingPatrick Peters, Bob Zordani, Dan Von Holtenpage 17 A Man of Jackson IV (City Dweller)Steven M. Beamerpage 19 11:45 p.m. FridayElizabeth McMeekanpage 20 Mr. Siegel-January 1967Timothy J. McCarthypage 21 She had a look about herA bag man of Jackson pauses for a portraitSteven M. Beamerpage 22 Citybed (Homeless of Chicago)Steven M. Beamerpage 23 Electra and the Eighteen WheelerTammy Veachpage 24 OrderRhonda Ealypage 28 Grave Mill ISteven M. Beamerpage 29 The Party (A Social Event in 80 Words or Less)Groucho Smithpage 30 Graceland and Elvis Presley EarmuffsCraig Titleypage 31 Learning to ForageDan Von Holtenpage 33 One Last Peanut at Gateway CenterReflections of Three with DeCicco and LadySteven M. Beamerpage 34 Letter from the MidwestPatrick Peterspage 35 WoodwindJim Reedpage 36 Excerpts from Notebook AustraliaKeith Schusterpage 37 Letter from the DesertPatrick Peterspage 40 Tinted Blue, Waiting for an Uptown TaxiMichael Salempage 42 Voice and Earth: A Review of The Invention of the Telephone by Bruce GuernseyDan Von Holtenpage 43https://thekeep.eiu.edu/vehicle/1052/thumbnail.jp

The Vehicle, Spring 1988

Contents CitizenCraig Titleypage 3 Justice DistributionAngie Geraldpage 4 Letter from My MotherDan Von Holtenpage 6 The Fool and His LadyRodger Patiencepage 7 What Big IsBob Zordanipage 8 Blind ArchitectureJim Reedpage 9 Ah, What a Funny Thing These EyesCraig Titleypage 10 FarmingPatrick Peterspage 11 The CowSteven M. Beamerpage 13 The Enigma of My ExistenceAngie Kathpage 14 Neon TeethMichael Salempage 15 Zombie PoseidonMichael Salempage 16 From: Letters from the Linder BuildingPatrick Peters, Bob Zordani, Dan Von Holtenpage 17 A Man of Jackson IV (City Dweller)Steven M. Beamerpage 19 11:45 p.m. FridayElizabeth McMeekanpage 20 Mr. Siegel-January 1967Timothy J. McCarthypage 21 She had a look about herA bag man of Jackson pauses for a portraitSteven M. Beamerpage 22 Citybed (Homeless of Chicago)Steven M. Beamerpage 23 Electra and the Eighteen WheelerTammy Veachpage 24 OrderRhonda Ealypage 28 Grave Mill ISteven M. Beamerpage 29 The Party (A Social Event in 80 Words or Less)Groucho Smithpage 30 Graceland and Elvis Presley EarmuffsCraig Titleypage 31 Learning to ForageDan Von Holtenpage 33 One Last Peanut at Gateway CenterReflections of Three with DeCicco and LadySteven M. Beamerpage 34 Letter from the MidwestPatrick Peterspage 35 WoodwindJim Reedpage 36 Excerpts from Notebook AustraliaKeith Schusterpage 37 Letter from the DesertPatrick Peterspage 40 Tinted Blue, Waiting for an Uptown TaxiMichael Salempage 42 Voice and Earth: A Review of The Invention of the Telephone by Bruce GuernseyDan Von Holtenpage 43https://thekeep.eiu.edu/vehicle/1052/thumbnail.jp

The Vehicle, Fall 1987

Table of Contents Sketches in the SunRodger L. Patiencepage 3 Reflecting PoolRob Montgomerypage 5 Grandpa\u27s Porcelain DollRichard E. Hallpage 6 Tintype 1837Catherine Friemannpage 6 PhotographSteven M. Beamerpage 7 Washerwoman\u27s SongBob Zordanipage 8 Scrambled Eggs for D.O.Lynne A. Rafoolpage 8 my mother would sayMonica Grothpage 9 Retired by His ChildrenDan Von Holtenpage 10 I am the oldestMonica Grothpage 11 Ice on WheatRob Montgomerypage 12 The Nature of the RoseTroy Mayfieldpage 12 Past NebraskaDan Hornbostelpage 13 Five Minute Jamaican VacationChristy Dunphypage 14 PhotographSteven M. Beamerpage 14 The Angry PoemChristy Dunphypage 15 Road UnfamiliarChristy Dunphypage 15 raised voicesMonica Grothpage 16 Old Ladies & MiniskirtsKara Shannonpage 17 FreakspeakBob Zordanipage 18 PortraitDan Von Holtenpage 18 Mobile VacuumKathleen L. Fairfieldpage 19 Rev. Fermus DickSteve Hagemannpage 20 PhotographSteven M. Beamerpage 21 What\u27s the Name of That Flower?Richard Jesse Davispage 22 RequestChristy Dunphypage 23 SketchPaul Seabaughpage 24 ExperiencedMarilyn Wilsonpage 26 Leaving: Two ViewsTina Phillipspage 27 AntaeusDan Von Holtenpage 28 Misogyny at 19J. D. Finfrockpage 29 A Mental CrippleSteve Hagemannpage 32 AssociationsRhonda Ealypage 33 Banana BreadGail Bowerpage 34 Bill and JackBradford B. Autenpage 35 After Image No. 2Rob Montgomerypage 35 VrrooomBeth Goodmanpage 36 Mr. Modern LoverMolly Maddenpage 36 TravelogueRodger L. Patiencepage 37 Down the HighwayJoan Sebastianpage 38 A Retread HeavenRob Montgomerypage 41 StuporDan Von Holtenpage 42 Love Poem After a Seizure in Your BedBob Zordanipage 43 PalsyChristy Dunphypage 44 Interview with Mr. MatthewsBob Zordanipage 45 Chasing Down Hot Air Balloons on a Sunday MorningRob Montgomerypage 48https://thekeep.eiu.edu/vehicle/1049/thumbnail.jp

Sex differences in money pathology in the general population

This study examined sex differences in money beliefs and behaviours. Over 100,000 British participants completed two measures online, one of which assessed “money pathology” (Forman in Mind over money, Doubleday, Toronto, 1987), and the other four “money types”, based on the emotional associations of money (Furnham et al. in Personal Individ Differ, 52:707–711, 2012). Nearly all measures showed significant sex differences with medium to large effect sizes, and with females exhibiting more “money pathology” than males. The biggest difference on the money types was on money being associated with generosity (money representing love) where men scored much lower than females, and autonomy (money representing freedom) where men scored higher than women. For men, more than women, money represented Power and Security. Men were more likely to be Hoarders while women did more emotional regulatory purchasing. Implications and limitations of this study are discussed