High-gain weakly nonlinear flux-modulated Josephson parametric amplifier using a SQUID-array

We have developed and measured a high-gain quantum-limited microwave parametric amplifier based on a superconducting lumped LC resonator with the inductor L including an array of 8 superconducting quantum interference devices (SQUIDs). This amplifier is parametrically pumped by modulating the flux threading the SQUIDs at twice the resonator frequency. Around 5 GHz, a maximum gain of 31 dB, a product amplitude-gain x bandwidth above 60 MHz, and a 1 dB compression point of -123 dBm at 20 dB gain are obtained in the non-degenerate mode of operation. Phase sensitive amplification-deamplification is also measured in the degenerate mode and yields a maximum gain of 37 dB. The compression point obtained is 18 dB above what would be obtained with a single SQUID of the same inductance, due to the smaller nonlinearity of the SQUID array.Comment: 7 pages, 4 figures, 23 reference

Multiplexed Readout of Transmon Qubits with Josephson Bifurcation Amplifiers

Achieving individual qubit readout is a major challenge in the development of scalable superconducting quantum processors. We have implemented the multiplexed readout of a four transmon qubit circuit using non-linear resonators operated as Josephson bifurcation amplifiers. We demonstrate the simultaneous measurement of Rabi oscillations of the four transmons. We find that multiplexed Josephson bifurcation is a high-fidelity readout method, the scalability of which is not limited by the need of a large bandwidth nearly quantum-limited amplifier as is the case with linear readout resonators.Comment: 7 pages, 6 figures, and 31 reference

Dos lepiotas mediterráneas poco conocidas

Se describen Echinoderma sinopicum y Lepiota griseovirens, recolectadas en el centro peninsular en suelos arenosos básicos. Se aportan macro . y microfotografias de las características más sobresalientes de ambas especies, así como datos coro lógicos, taxonómicos y bibliográficos. Ambas especies presentan interés corológico por su marcada distribución mediterránea.Two little known mediterranean species of Lepiota. Echinoderma sinopicum and Lepiota griseovirens, found in sandy and calcareous soils in central Spain, are described. Macro and microphotographs of the most striking features of both taxa, as well as chorological, taxonomical and bibliographical data, are added. 80th taxa show some chorological interest, because of their marked mediterranean distribution

Dos lepiotas mediterráneas poco conocidas

Two little known mediterranean species of Lepiota. Echinoderma sinopicum and Lepiota griseovirens, found in sandy and calcareous soils in central Spain, are described. Macro and microphotographs of the most striking features of both taxa, as well as chorological, taxonomical and bibliographical data, are added. 80th taxa show some chorological interest, because of their marked mediterranean distribution.Se describen Echinoderma sinopicum y Lepiota griseovirens, recolectadas en el centro peninsular en suelos arenosos básicos. Se aportan macro . y microfotografias de las características más sobresalientes de ambas especies, así como datos coro lógicos, taxonómicos y bibliográficos. Ambas especies presentan interés corológico por su marcada distribución mediterránea

Multi-mode storage and retrieval of microwave fields in a spin ensemble

A quantum memory at microwave frequencies, able to store the state of multiple superconducting qubits for long times, is a key element for quantum information processing. Electronic and nuclear spins are natural candidates for the storage medium as their coherence time can be well above one second. Benefiting from these long coherence times requires to apply the refocusing techniques used in magnetic resonance, a major challenge in the context of hybrid quantum circuits. Here we report the first implementation of such a scheme, using ensembles of nitrogen-vacancy (NV) centres in diamond coupled to a superconducting resonator, in a setup compatible with superconducting qubit technology. We implement the active reset of the NV spins into their ground state by optical pumping and their refocusing by Hahn echo sequences. This enables the storage of multiple microwave pulses at the picoWatt level and their retrieval after up to $35 \mu$s, a three orders of magnitude improvement compared to previous experiments.Comment: 8 pages, 5 figures + Supplementary information (text and 6 figures

Transcription factor LSF-DNMT1 complex dissociation by FQI1 leads to aberrant DNA methylation and gene expression

The transcription factor LSF is highly expressed in hepatocellular carcinoma (HCC) and promotes oncogenesis. Factor quinolinone inhibitor 1 (FQI1), inhibits LSF DNA-binding activity and exerts anti-proliferative activity. Here, we show that LSF binds directly to the maintenance DNA (cytosine-5) methyltransferase 1 (DNMT1) and its accessory protein UHRF1 both in vivo and in vitro. Binding of LSF to DNMT1 stimulated DNMT1 activity and FQI1 negated the methyltransferase activation. Addition of FQI1 to the cell culture disrupted LSF bound DNMT1 and UHRF1 complexes, resulting in global aberrant CpG methylation. Differentially methylated regions (DMR) containing at least 3 CpGs, were significantly altered by FQI1 compared to control cells. The DMRs were mostly concentrated in CpG islands, proximal to transcription start sites, and in introns and known genes. These DMRs represented both hypo and hypermethylation, correlating with altered gene expression. FQI1 treatment elicits a cascade of effects promoting altered cell cycle progression. These findings demonstrate a novel mechanism of FQI1 mediated alteration of the epigenome by DNMT1-LSF complex disruption, leading to aberrant DNA methylation and gene expression.We would like to thank Drs. Donald Comb, Rich Roberts, William Jack and Clotilde Carlow at New England Biolabs Inc. for research support and encouragement. The authors thank Dr. Lauren Brown (Boston University Center for Molecular Discovery) for the preparation of FQI1. UH research on this project was supported by Ignition Awards from Boston University and a Johnson & Johnson Clinical Innovator's Award through Boston University. SES research is supported by the NIH (P50 GM067041 & R24 GM111625). Research performed by HGC was partly a requirement for the MCBB graduate program at Boston University and supported by NEB. (Boston University; Johnson & Johnson Clinical Innovator's Award through Boston University; P50 GM067041 - NIH; R24 GM111625 - NIH; NEB)Published versio

Characterization of a two-transmon processor with individual single-shot qubit readout

We report the characterization of a two-qubit processor implemented with two capacitively coupled tunable superconducting qubits of the transmon type, each qubit having its own non-destructive single-shot readout. The fixed capacitive coupling yields the \sqrt{iSWAP} two-qubit gate for a suitable interaction time. We reconstruct by state tomography the coherent dynamics of the two-bit register as a function of the interaction time, observe a violation of the Bell inequality by 22 standard deviations after correcting readout errors, and measure by quantum process tomography a gate fidelity of 90%

Storage and Retrieval of a Microwave Field in a Spin Ensemble

We report the storage and retrieval of a small microwave field from a superconducting resonator into collective excitations of a spin ensemble. The spins are nitrogen-vacancy centers in a diamond crystal. The storage time of the order of 30 ns is limited by inhomogeneous broadening of the spin ensemble.Comment: 4 pages + supplementary material. Submitted to PR