224 research outputs found
BRS "Symmetry", prehistory and history
Prehistory - Starting from 't Hooft's (1971) we have a short look at Taylor's
and Slavnov's works (1971-72) and at the lectures given by Rouet and Stora in
Lausanne-1973 which determine the transition from pre-history to history.
History - We give a brief account of the main analyses and results of the BRS
collaboration concerning the renormalized gauge theories, in particular the
method of the regularization independent, algebraic renormalization, the
algebraic proof of S-matrix unitarity and that of gauge choice independence of
the renormalized physics. We conclude this report with a suggestion to the
crucial question: what could remain of BRS invariance beyond perturbation
theory.Comment: Talk given at: A Special day in honour of Raymond Stora, Annecy, July
8, 201
A survey of medical students to assess their exposure to and knowledge of renal transplantation
BACKGROUND: Within the field of renal transplantation there is a lack of qualified and trainee surgeons and a shortage of donated organs. Any steps to tackle these issues should, in part, be aimed at future doctors. METHODS: A questionnaire was distributed to final year students at a single medical school in the UK to assess their exposure to and knowledge of renal transplantation. RESULTS: Although 46% of responding students had examined a transplant recipient, only 14% had ever witnessed the surgery. Worryingly, 9% of students believed that xenotransplantation commonly occurs in the UK and 35% were unable to name a single drug that a recipient may need to take. CONCLUSIONS: This survey demonstrates a lack of exposure to, and knowledge of, the field of renal transplantation. Recommendations to address the problems with the recruitment of surgeons and donation of organs, by targeting medical students are made
The Heat Kernel on AdS_3 and its Applications
We derive the heat kernel for arbitrary tensor fields on S^3 and (Euclidean)
AdS_3 using a group theoretic approach. We use these results to also obtain the
heat kernel on certain quotients of these spaces. In particular, we give a
simple, explicit expression for the one loop determinant for a field of
arbitrary spin s in thermal AdS_3. We apply this to the calculation of the one
loop partition function of N=1 supergravity on AdS_3. We find that the answer
factorizes into left- and right-moving super Virasoro characters built on the
SL(2, C) invariant vacuum, as argued by Maloney and Witten on general grounds.Comment: 46 pages, LaTeX, v2: Reference adde
The scale of population structure in Arabidopsis thaliana
The population structure of an organism reflects its evolutionary history and influences its evolutionary trajectory. It constrains the combination of genetic diversity and reveals patterns of past gene flow. Understanding it is a prerequisite for detecting genomic regions under selection, predicting the effect of population disturbances, or modeling gene flow. This paper examines the detailed global population structure of Arabidopsis thaliana. Using a set of 5,707 plants collected from around the globe and genotyped at 149 SNPs, we show that while A. thaliana as a species self-fertilizes 97% of the time, there is considerable variation among local groups. This level of outcrossing greatly limits observed heterozygosity but is sufficient to generate considerable local haplotypic diversity. We also find that in its native Eurasian range A. thaliana exhibits continuous isolation by distance at every geographic scale without natural breaks corresponding to classical notions of populations. By contrast, in North America, where it exists as an exotic species, A. thaliana exhibits little or no population structure at a continental scale but local isolation by distance that extends hundreds of km. This suggests a pattern for the development of isolation by distance that can establish itself shortly after an organism fills a new habitat range. It also raises questions about the general applicability of many standard population genetics models. Any model based on discrete clusters of interchangeable individuals will be an uneasy fit to organisms like A. thaliana which exhibit continuous isolation by distance on many scales
Brain Neuronal CB2 Cannabinoid Receptors in Drug Abuse and Depression: From Mice to Human Subjects
BACKGROUND: Addiction and major depression are mental health problems associated with stressful events in life with high relapse and reoccurrence even after treatment. Many laboratories were not able to detect the presence of cannabinoid CB2 receptors (CB2-Rs) in healthy brains, but there has been demonstration of CB2-R expression in rat microglial cells and other brain associated cells during inflammation. Therefore, neuronal expression of CB2-Rs had been ambiguous and controversial and its role in depression and substance abuse is unknown. METHODOLOGY/PRINCIPAL FINDINGS: In this study we tested the hypothesis that genetic variants of CB2 gene might be associated with depression in a human population and that alteration in CB2 gene expression may be involved in the effects of abused substances including opiates, cocaine and ethanol in rodents. Here we demonstrate that a high incidence of (Q63R) but not (H316Y) polymorphism in the CB2 gene was found in Japanese depressed subjects. CB2-Rs and their gene transcripts are expressed in the brains of naïve mice and are modulated following exposure to stressors and administration of abused drugs. Mice that developed alcohol preference had reduced CB2 gene expression and chronic treatment with JWH015 a putative CB2-R agonist, enhanced alcohol consumption in stressed but not in control mice. The direct intracerebroventricular microinjection of CB2 anti-sense oligonucleotide into the mouse brain reduced mouse aversions in the plus-maze test, indicating the functional presence of CB2-Rs in the brain that modifies behavior. We report for the using electron microscopy the sub cellular localization of CB2-Rs that are mainly on post-synaptic elements in rodent brain. CONCLUSIONS/SIGNIFICANCE: Our data demonstrate the functional expression of CB2-Rs in brain that may provide novel targets for the effects of cannabinoids in depression and substance abuse disorders beyond neuro-immunocannabinoid activity
Event-related alpha suppression in response to facial motion
This article has been made available through the Brunel Open Access Publishing Fund.While biological motion refers to both face and body movements, little is known about the visual perception of facial motion. We therefore examined alpha wave suppression as a reduction in power is thought to reflect visual activity, in addition to attentional reorienting and memory processes. Nineteen neurologically healthy adults were tested on their ability to discriminate between successive facial motion captures. These animations exhibited both rigid and non-rigid facial motion, as well as speech expressions. The structural and surface appearance of these facial animations did not differ, thus participants decisions were based solely on differences in facial movements. Upright, orientation-inverted and luminance-inverted facial stimuli were compared. At occipital and parieto-occipital regions, upright facial motion evoked a transient increase in alpha which was then followed by a significant reduction. This finding is discussed in terms of neural efficiency, gating mechanisms and neural synchronization. Moreover, there was no difference in the amount of alpha suppression evoked by each facial stimulus at occipital regions, suggesting early visual processing remains unaffected by manipulation paradigms. However, upright facial motion evoked greater suppression at parieto-occipital sites, and did so in the shortest latency. Increased activity within this region may reflect higher attentional reorienting to natural facial motion but also involvement of areas associated with the visual control of body effectors. © 2014 Girges et al
Dynamics and transport near quantum-critical points
The physics of non-zero temperature dynamics and transport near
quantum-critical points is discussed by a detailed study of the O(N)-symmetric,
relativistic, quantum field theory of a N-component scalar field in spatial
dimensions. A great deal of insight is gained from a simple, exact solution of
the long-time dynamics for the N=1 d=1 case: this model describes the critical
point of the Ising chain in a transverse field, and the dynamics in all the
distinct, limiting, physical regions of its finite temperature phase diagram is
obtained. The N=3, d=1 model describes insulating, gapped, spin chain
compounds: the exact, low temperature value of the spin diffusivity is
computed, and compared with NMR experiments. The N=3, d=2,3 models describe
Heisenberg antiferromagnets with collinear N\'{e}el correlations, and
experimental realizations of quantum-critical behavior in these systems are
discussed. Finally, the N=2, d=2 model describes the superfluid-insulator
transition in lattice boson systems: the frequency and temperature dependence
of the the conductivity at the quantum-critical coupling is described and
implications for experiments in two-dimensional thin films and inversion layers
are noted.Comment: Lectures presented at the NATO Advanced Study Institute on "Dynamical
properties of unconventional magnetic systems", Geilo, Norway, April 2-12,
1997, edited by A. Skjeltorp and D. Sherrington, Kluwer Academic, to be
published. 46 page
Electron quantum metamaterials in van der Waals heterostructures
In recent decades, scientists have developed the means to engineer synthetic
periodic arrays with feature sizes below the wavelength of light. When such
features are appropriately structured, electromagnetic radiation can be
manipulated in unusual ways, resulting in optical metamaterials whose function
is directly controlled through nanoscale structure. Nature, too, has adopted
such techniques -- for example in the unique coloring of butterfly wings -- to
manipulate photons as they propagate through nanoscale periodic assemblies. In
this Perspective, we highlight the intriguing potential of designer
sub-electron wavelength (as well as wavelength-scale) structuring of electronic
matter, which affords a new range of synthetic quantum metamaterials with
unconventional responses. Driven by experimental developments in stacking
atomically layered heterostructures -- e.g., mechanical pick-up/transfer
assembly -- atomic scale registrations and structures can be readily tuned over
distances smaller than characteristic electronic length-scales (such as
electron wavelength, screening length, and electron mean free path). Yet
electronic metamaterials promise far richer categories of behavior than those
found in conventional optical metamaterial technologies. This is because unlike
photons that scarcely interact with each other, electrons in subwavelength
structured metamaterials are charged, and strongly interact. As a result, an
enormous variety of emergent phenomena can be expected, and radically new
classes of interacting quantum metamaterials designed
Single Feature Polymorphism Discovery in Rice
The discovery of nucleotide diversity captured as single feature polymorphism (SFP) by using the expression array is a high-throughput and effective method in detecting genome-wide polymorphism. The efficacy of such method was tested in rice, and the results presented in the paper indicate high sensitivity in predicting SFP. The sensitivity of polymorphism detection was further demonstrated by the fact that no biasness was observed in detecting SFP with either single or multiple nucleotide polymorphisms. The high density SFP data that can be generated quite effectively by the current method has promise for high resolution genetic mapping studies, as physical location of features are well-defined on rice genome
The association of physical activity, sedentary behaviors, and body mass index classification in a cross-sectional analysis: are the effects homogenous?
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