Birth Weight Relations in Human Multipara

It has been shown previously that the weight (W) of an entire litter of newborn young of multiparous mammals is proportional to the number (N) in the litter. This proportionality may be expressed by the empirical equation K W=N+C where K is assumed to have the properties of a partition coefficient and expresses the manner in which a limited nutritional supply is shared by the members oi the litter. This relationship also holds for human multipara, though it is modified by the inability of the human mother to increase the nutritional level to the same extent as other species we have investigated

Ectopia Cordis in a 35 Day Old Human Embryo

One of the major, though fortunately rare, abnormalities of human intrauterine development is a condition known as ectopia cordis. It was first described by the Swiss poet, physician and naturalist Haller in 1706. Arey (1954) briefly characterizes ectopia cordis as an abnormality in which the heart protrudes from the anterior body wall between the widely separated halves of the sternum, and comes to lie exposed on the surface of the chest. Others (cf. De Abbot) have described ectopia cordis as an abnormality in which the heart is malpositioned, high up in the chest, protruding out from the body in the pectoral area, or even displaced into the abdominal cavity

Report on a Retroperitoneal Teratoma (Foetus in foetu)

Successful removal of a retroperitoneal teratoma from an infant is described. Various theories dealing with the origin of such tumors are discussed. Blood supply, hemopoiesis and circulation of the tumor have been investigated

Evaluation of real-life outcome data of patients with spinal muscular atrophy treated with nusinersen in Switzerland.

Spinal muscular atrophy (SMA) is an autosomal recessive disorder causing progressive proximal muscular, respiratory, and bulbar weakness. We present outcome data on motor function, ventilation, nutrition, and language development of SMA patients treated with nusinersen in Switzerland. This multicenter, observational study included 44 patients. At treatment initiation, after 2 months and then every 4 months we assessed motor function with the Children's Hospital of Philadelphia Infant Test of Neuromuscular Disorders (CHOP-INTEND), Hammersmith Functional Motor Scale expanded (HFMSE) and 6-Minute Walk Test (6MWT). At treatment initiation, patients were 0.1-44.6 years old, treatment duration ranged from 6 to 41 months. All 11 SMA type 1 children achieved higher CHOP-INTEND scores at the last assessment compared to treatment initiation, 4 acquired stable sitting. Six type 1 children were <18 months-old at treatment initiation. Two of them did not need ventilation or nutritional support at the last assessment; three had delayed language development and 3 articulation difficulties. 5/21 SMA type 2 patients achieved higher HFMSE scores. All ambulant type 3 patients showed a gain in the 6MWT. Nusinersen is an effective treatment, with gains in motor function occurring particularly in children and SMA type 1, but also in type 2 and 3, adolescents and adults

International self-report delinquency (ISRD4) study protocol: background, methodology, and mandatory items for the 2021/2022 survey

This document describes the background and methodology of the fourth round of the International Self-Report Delinquency study (ISRD4). Drawing from the fields of criminology, public health and cross-national methodology, the ISRD is an ongoing multi-national research study that aims to describe and explain adolescents’ experiences with crime and victimization, to test criminological theories, and to develop recommendations for prevention and interventions. The project relies on a common research protocol, which standardizes questionnaire content and administration, and prescribes comparable sampling procedures in participating countries enabling the collection of common data across all of them. The ISRD4 Study Protocol describes the standard sections of the ISRD4 questionnaire (core and sweep-specific), for both the school-based as well as the internet-based samples. In addition to the core ISRD items, the ISRD4 questionnaire includes new items related to cyber-offending and –victimization, discrimination, and perceptions of violence and revenge motives. The protocol also describes the rationale for including an internet-based survey as a complement to the school-based survey. The document aims to provide a detailed set of guidelines for participating national teams but will also be of interest to researchers interested in youth victimization and offending, theory-testing, and cross-national methodology. Fieldwork in approximately 40 countries began in 2020 and will conclude by the end of 2022

Nanoparticle–membrane interactions

Engineered nanomaterials have a wide range of applications and as a result, are increasingly present in the environment. While they offer new technological opportunities, there is also the potential for adverse impact, in particular through possible toxicity. In this review, we discuss the current state of the art in the experimental characterisation of nanoparticle-membrane interactions relevant to the prediction of toxicity arising from disruption of biological systems. One key point of discussion is the urgent need for more quantitative studies of nano-bio interactions in experimental models of lipid system that mimic in vivo membranes

Contemporary challenges in school recruitment for criminological survey research: lessons from the international self-report delinquency study in England, Germany, the Netherlands, and the United States

Several multiwave cross-national surveys have experienced drops in school participation for youth health and risk behavior (HRB) surveys in Western European countries. This article considers explanations for the challenge in recruiting schools for surveys in England, Germany, the Netherlands, and the United States and the most important lessons learned during school recruitment for the third wave of the International Self-Report Delinquency Study in these four countries. Comparing school response rates for international academic surveys with those focused on HRB, schools have been increasingly less likely to participate in HRB surveys over the past two decades. However, considerable variation within and across surveys and countries suggests there are numerous influences on school recruitment, and there may be facilitators on which researchers could capitalize. We conclude that when planning future school-based HRB surveys, researchers should consider multiple strategies to engage schools from the outset, tailored to regional and national settings

Rates of self-reported delinquency among Western Australian male and female high school students: the malefemale gender gap

The Adapted Self-Report Delinquency Scale (ASDS) was administered to 328 adolescents (174 males and 154 females) from eight high schools in Perth, Western Australia. The ages of the sample ranged from 13 to 17 years. Males reported a greater percentage level of involvement than females in 36 of 40 individual delinquent behaviours comprising the ASDS. A between-subjects multivariate analysis of variance using a Bonferroni adjusted alpha revealed a significant multivariate main effect of gender, F(6, 318) = 3.98, p < 0.001, partial η2 = 0.08. No significant main effect of age was evident. Univariate F-tests revealed that males scored significantly higher than females on only one of seven delinquent factors (physical aggression). These data are discussed in light of established evidence showing male predominance in delinquency, recent reports suggesting a male-female gender gap, and theories that have attempted to explain this disparity in offending among males and females

Current european regulatory perspectives on insulin analogues

Insulin analogues are increasingly considered as an alternative to human insulin in the therapy of diabetes mellitus. Insulin analogues (IAs) are chemically different from human insulin and may have different pharmacokinetic or pharmacodynamic properties. The significance of the modifications of the insulin molecule for the safety profile of IAs must be considered. This review describes the regulatory procedure and the expectations for the scientific content of European marketing authorization applications for innovative IAs submitted to the European Medicines Agency. Particular consideration is given to a potential cancer hazard. Specific regulatory guidance on how to address a possible carcinogenic or tumor promoting effect of innovative IAs in non-clinical studies is available. After marketing authorization, the factual access of patients to the new product will be determined to great extent by health technology assessment bodies, reimbursement decisions and the price. Whereas the marketing authorization is a European decision, pricing and reimbursement are national or regional responsibilities. The assessment of benefit and risk by the European Medicines Agency is expected to influence future decisions on price and reimbursement on a national or regional level. Collaborations between regulatory agencies and health technology assessment bodies have been initiated on European and national level to facilitate the use of the European Medicines Agency's benefit risk assessment as basis on which to build the subsequent health technology assessment. The option for combined or joint scientific advice procedures with regulators and health technology assessment bodies on European level or on a national level in several European Member States may help applicants to optimize their development program and dossier preparation in regard of both European marketing authorization application and reimbursement decisions