11 research outputs found
Perfil de egressos da Pós-Graduação stricto sensu na årea de Gerenciamento em Enfermagem da EEUSP
Ptilophora leliaertii and Ptilophora coppejansii, two new species of Gelidiales (Rhodophyta) from South Africa
Mitogenomes from type specimens, a genotyping tool for morphologically simple species: ten genomes of agar-producing red algae
Occurrence and expression of acid phosphatase of Hymenoscyphus ericae (Read) Korf & Kernan, in isolation or associated with plant roots
A Comparative Biomass Compositional Analysis of Five Algal Species from the Paddy Fields of Burdwan District, West Bengal, India, to Determine Their Suitability for Handmade Paper Pulp Formulation
Cell Wall Modifications during Conidial Maturation of the Human Pathogenic Fungus Pseudallescheria boydii
Intelligence, educational attainment, and brain structure in those at familial highârisk for schizophrenia or bipolar disorder
Firstâdegree relatives of patients diagnosed with schizophrenia (SZâFDRs) show similar patterns of brain abnormalities and cognitive alterations to patients, albeit with smaller effect sizes. Firstâdegree relatives of patients diagnosed with bipolar disorder (BDâFDRs) show divergent patterns; on average, intracranial volume is larger compared to controls, and findings on cognitive alterations in BDâFDRs are inconsistent. Here, we performed a metaâanalysis of global and regional brain measures (cortical and subcortical), current IQ, and educational attainment in 5,795 individuals (1,103 SZâFDRs, 867 BDâFDRs, 2,190 controls, 942 schizophrenia patients, 693 bipolar patients) from 36 schizophrenia and/or bipolar disorder family cohorts, with standardized methods. Compared to controls, SZâFDRs showed a pattern of widespread thinner cortex, while BDâFDRs had widespread larger cortical surface area. IQ was lower in SZâFDRs (d = â0.42, p = 3âĂâ10â5), with weak evidence of IQ reductions among BDâFDRs (d = â0.23, p = .045). Both relative groups had similar educational attainment compared to controls. When adjusting for IQ or educational attainment, the groupâeffects on brain measures changed, albeit modestly. Changes were in the expected direction, with less pronounced brain abnormalities in SZâFDRs and more pronounced effects in BDâFDRs. To conclude, SZâFDRs and BDâFDRs show a differential pattern of structural brain abnormalities. In contrast, both had lower IQ scores and similar school achievements compared to controls. Given that brain differences between SZâFDRs and BDâFDRs remain after adjusting for IQ or educational attainment, we suggest that differential brain developmental processes underlying predisposition for schizophrenia or bipolar disorder are likely independent of general cognitive impairment
Human Serum Promotes Candida albicans Biofilm Growth and Virulence Gene Expression on Silicone Biomaterial
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What we learn about bipolar disorder from large-scale neuroimaging: Findings and future directions from the ENIGMA Bipolar Disorder Working Group.
MRI-derived brain measures offer a link between genes, the environment and behavior and have been widely studied in bipolar disorder (BD). However, many neuroimaging studies of BD have been underpowered, leading to varied results and uncertainty regarding effects. The Enhancing Neuro Imaging Genetics through Meta-Analysis (ENIGMA) Bipolar Disorder Working Group was formed in 2012 to empower discoveries, generate consensus findings and inform future hypothesis-driven studies of BD. Through this effort, over 150 researchers from 20 countries and 55 institutions pool data and resources to produce the largest neuroimaging studies of BD ever conducted. The ENIGMA Bipolar Disorder Working Group applies standardized processing and analysis techniques to empower large-scale meta- and mega-analyses of multimodal brain MRI and improve the replicability of studies relating brain variation to clinical and genetic data. Initial BD Working Group studies reveal widespread patterns of lower cortical thickness, subcortical volume and disrupted white matter integrity associated with BD. Findings also include mapping brain alterations of common medications like lithium, symptom patterns and clinical risk profiles and have provided further insights into the pathophysiological mechanisms of BD. Here we discuss key findings from the BD working group, its ongoing projects and future directions for large-scale, collaborative studies of mental illness