52 research outputs found
Climate negotiatorsâ and scientistsâ assessments of the climate negotiations
Climate negotiation outcomes are difficult to evaluate objectively because there are no clear reference scenarios. Subjective assessments from those directly involved in the negotiations are particularly important, as this may influence strategy and future negotiation participation. Here we analyze the perceived success of the climate negotiations in a sample of more than 600 experts involved in international climate policy. Respondents were pessimistic when asked for specific assessments of the current approach centered on voluntary pledges, but were more optimistic when asked for general assessments of the outcomes and usefulness of the climate negotiations. Individuals who are more involved in the negotiation process tended to be more optimistic, especially in terms of general assessments. Our results indicate that two reinforcing effects are at work: a high degree of involvement changes individualsâ perceptions and more optimistic individuals are more inclined to remain involved in the negotiations
A critical review of smaller state diplomacy
In The Peloponnesian War, Thucydides (1972: 402) highlights the effects of the general, overall
weakness of smaller states vis-Ă -vis larger, more powerful ones in a key passage, where the
Athenians remind the Melians that:
â⊠since you know as well as we do that, as the world goes, right is only in question
between equals in power. Meanwhile, the strong do what they can and the weak suffer
what they must.â
Concerns about the vulnerability of small, weak, isolated states have echoed throughout history:
from Thucydides, through the review by Machiavelli (1985) of the risks of inviting great powers
to intervene in domestic affairs, through 20th century US-led contemporary political science
(Vital, 1971; Handel, 1990) and Commonwealth led scholarship (Commonwealth Secretariat,
1985). In the context of 20th century âBalkanizationâ, the small state could also prove unstable,
even hostile and uncooperative, a situation tempting enough to invite the intrusion of more
powerful neighbours: a combination, according to Brzezinski (1997: 123-124) of a power
vacuum and a corollary power suction2: in the outcome, if the small state is âabsorbedâ, it would
be its fault, and its destiny, in the grand scheme of things. In an excellent review of small states
in the context of the global politics of development, Payne (2004: 623, 634) concludes that
âvulnerabilities rather than opportunities are the most striking consequence of smallnessâ. It has
been recently claimed that, since they cannot defend or represent themselves adequately, small
states âlack real independence, which makes them suboptimal participants in the international
systemâ (Hagalin, 2005: 1).
There is however, a less notable and acknowledged but more extraordinary strand of
argumentation that considers âthe power of powerlessnessâ, and the ability of small states to
exploit their smaller size in a variety of ways in order to achieve their intended, even if unlikely,
policy outcomes. The pursuance of smaller state goals becomes paradoxically acceptable and
achievable precisely because such smaller states do not have the power to leverage disputants or
pursue their own agenda. A case in point concerns the smallest state of all, the Vatican, whose
powers are both unique and ambiguous, but certainly not insignificant (The Economist, 2007).
Smaller states have âpunched above their weightâ (e.g. Edis, 1991); and, intermittently, political scientists confront their âamazing intractabilityâ (e.g. Suhrke, 1973: 508). Henry Kissinger
(1982: 172) referred to this stance, with obvious contempt, as âthe tyranny of the weakâ3.
This paper seeks a safe passage through these two, equally reductionist, propositions. It
deliberately focuses first on a comparative case analysis of two, distinct âsmall state-big stateâ
contests drawn from the 1970s, seeking to infer and tease out the conditions that enable smaller
âLilliputianâ states (whether often or rarely) to beat their respective Goliaths. The discussion is
then taken forward to examine whether similar tactics can work in relation to contemporary
concerns with environmental vulnerability, with a focus on two other, small island states. Before
that, the semiotics of âthe small stateâ need to be explored, since they are suggestive of the
perceptions and expectations that are harboured by decision makers at home and abroad and
which tend towards the self-fulfilling prophecy.peer-reviewe
Long non-coding RNAs: spatial amplifiers that control nuclear structure and gene expression
Over the past decade, it has become clear that mammalian genomes encode thousands of long non-coding RNAs (lncRNAs), many of which are now implicated in diverse biological processes. Recent work studying the molecular mechanisms of several key examples â including Xist, which orchestrates X chromosome inactivation â has provided new insights into how lncRNAs can control cellular functions by acting in the nucleus. Here we discuss emerging mechanistic insights into how lncRNAs can regulate gene expression by coordinating regulatory proteins, localizing to target loci and shaping three-dimensional (3D) nuclear organization. We explore these principles to highlight biological challenges in gene regulation, in which lncRNAs are well-suited to perform roles that cannot be carried out by DNA elements or protein regulators alone, such as acting as spatial amplifiers of regulatory signals in the nucleus
The domestic effectiveness of international human rights monitoring in established democracies. The case of the UN human rights treaty bodies
Epigenetic engineering shows that a human centromere resists silencing mediated by H3K27me3/K9me3
Centromeres are characterized by the centromere-specific H3 variant CENP-A, which is embedded in chromatin with a pattern characteristic of active transcription that is required for centromere identity. It is unclear how centromeres remain transcriptionally active despite being flanked by repressive pericentric heterochromatin. To further understand centrochromatinâs response to repressive signals, we nucleated a Polycomb-like chromatin state within the centromere of a human artificial chromosome (HAC) by tethering the methyltransferase EZH2. This led to deposition of the H3K27me3 mark and PRC1 repressor binding. Surprisingly, this state did not abolish HAC centromere function or transcription, and this apparent resistance was not observed on a noncentromeric locus, where transcription was silenced. Directly tethering the reader/repressor PRC1 bypassed this resistance, inactivating the centromere. We observed analogous responses when tethering the heterochromatin Editor Suv39h1-methyltransferase domain (centromere resistance) or reader HP1α (centromere inactivation), respectively. Our results reveal that the HAC centromere can resist repressive pathways driven by H3K9me3/H3K27me3 and may help to explain how centromeres are able to resist inactivation by flanking heterochromatin
Long non-coding RNAs: spatial amplifiers that control nuclear structure and gene expression
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