46 research outputs found
CamĂ”es, figura literĂĄria hĂșngara
Na literatura hĂșngara do sĂ©culo XIX, LuĂs Vaz de CamĂ”es ocupa um lugar especial. NĂŁo apenas por ser um poeta que correspondia aos cĂąnones do Romantismo, senĂŁo tambĂ©m por mencionar a origem hĂșngara nâOs LusĂadas. Desta forma, tornou-se uma figura emblemĂĄtica que foi herĂłi de vĂĄrias obras de ficção hĂșngaras, nascidas pelo sĂ©culo XIX Afora, Ă s vezes personificando aspiraçÔes hĂșngaras.PALAVRAS-CHAVE: CamĂ”es, Os LusĂadas, romantismo, patriotismo
Treatment of relapsed and refractory multiple myeloma: recommendations from the International Myeloma Working Group
This Policy Review presents the International Myeloma Working Group's clinical practice recommendations for the treatment of relapsed and refractory multiple myeloma. Based on the results of phase 2 and phase 3 trials, these recommendations are proposed for the treatment of patients with relapsed and refractory disease who have received one previous line of therapy, and for patients with relapsed and refractory multiple myeloma who have received two or more previous lines of therapy. These recommendations integrate the issue of drug access in both low-income and middle-income countries and in high-income countries to help guide real-world practice and thus improve patient outcomes
ELISA-based assay of immunoglobulin G antibodies against mammalian cell entry 1A (Mce1A) protein: a novel diagnostic approach for leprosy
Integrative literature review of the reported uses of serological tests in leprosy management
Abstract: An integrative literature review was conducted to synthesize available publications regarding the potential use of serological tests in leprosy programs. We searched the databases Literatura Latino-Americana e do Caribe em CiĂȘncias da SaĂșde, Ăndice BibliogrĂĄfico Espanhol em CiĂȘncias da SaĂșde, Acervo da Biblioteca da Organização Pan-Americana da SaĂșde, Medical Literature Analysis and Retrieval System Online, HansenĂase, National Library of Medicine, Scopus, Ovid, Cinahl, and Web of Science for articles investigating the use of serological tests for antibodies against phenolic glycolipid-I (PGL-I), ML0405, ML2331, leprosy IDRI diagnostic-1 (LID-1), and natural disaccharide octyl-leprosy IDRI diagnostic-1 (NDO-LID). From an initial pool of 3.514 articles, 40 full-length articles fulfilled our inclusion criteria. Based on these papers, we concluded that these antibodies can be used to assist in diagnosing leprosy, detecting neuritis, monitoring therapeutic efficacy, and monitoring household contacts or at-risk populations in leprosy-endemic areas. Thus, available data suggest that serological tests could contribute substantially to leprosy management